Protein stabilization in spray drying and solid-state storage by using a 'molecular lock' - exploiting bacterial adaptations for industrial applications.

Small, stable biomedicines, like peptides and hormones, are already available on the market as spray dried formulations, however large biomolecules like antibodies and therapeutic enzymes continue to pose stability issues during the process. Stresses during solid-state formation are a barrier to formulation of large biotherapeutics as dry powders. Here, we explore an alternative avenue to protein stabilisation during the spray drying process, moving away from the use of excipients.

Access to Healthy Built and Natural Environments and Physical Activity and Screen Time in New Zealand Adolescents: A Geospatial Cross-Sectional Study.

The built and natural environment can facilitate (un)healthy behaviors in adolescence. However, most previous studies have focused on examining associations between singular aspects of the environment. This study examined the association between the mixture of health-promoting and health-constraining environmental features in a Healthy Location Index (HLI) and physical activity and screen time among adolescents.

The impact of exposure to green or bluespace on dietary intake and food choices among adults-A systematic literature review.

Extensive research has shown that spending time in natural greenspaces has a positive impact on health. However, there is limited evidence regarding potential factors that may influence these effects. This review aimed to assess the strength of the evidence and potential impact of exposure to green and bluespaces on dietary outcomes in adults.

Crystal engineering of a new platform of hybrid ultramicroporous materials and their CH/CO separation properties.

Hybrid ultramicroporous materials (HUMs) comprised of combinations of organic and inorganic linker ligands are a leading class of physisorbents for trace separations involving C1, C2 and C3 gases. First generation HUMs are modular in nature since they can be self-assembled from transition metal cations, ditopic linkers and inorganic "pillars", as exemplified by the prototypal variant, SIFSIX-3-Zn (3 = pyrazine, SIFSIX = SiF ). Conversely, HUMs that utilise chelating ligands such as ethylenediamine derivatives are yet to be explored as sorbents.

Framing the Labor of Paid Egg Donors in Iran: Marginality, Gendered Care, and Divine Reward.

Despite the economic incentives evidenced in the recruitment strategies of the Iranian fertility industry for egg donors, the official discourse put forward by policymakers conveys egg donation as an altruistic act. Drawing on ethnographic fieldwork in two fertility clinics in Tehran, I center the narratives of paid egg donors to investigate how multiple meanings are attributed to egg donation as a form of labor, demonstrating how reproductive inequalities are perpetuated in this context. Following feminist theorists of reproductive bioeconomies, I argue that Iranian donors experience and articulate their participation in local egg market through the prism of their economic marginality, gendered responsibilities, and religiously informed beliefs, including divine reward.

Water sorption studies with mesoporous multivariate monoliths based on UiO-66.

Hierarchical linker thermolysis has been used to enhance the porosity of monolithic UiO-66-based metal-organic frameworks (MOFs) containing 30 wt% 2-aminoterephthalic acid (BDC-NH) linker. In this multivariate ( mixed-linker) MOF, the thermolabile BDC-NH linker decomposed at ∼350 °C, inducing mesopore formation. The nitrogen sorption of these monolithic MOFs was probed, and an increase in gas uptake of more than 200 cm g was observed after activation by heating, together with an increase in pore volume and mean pore width, indicating the creation of mesopores.

Temperature promotes selectivity during electrochemical CO reduction on NiO:SnO nanofibers.

Electrolyzers operate over a range of temperatures; hence, it is crucial to design electrocatalysts that do not compromise the product distribution unless temperature can promote selectivity. This work reports a synthetic approach based on electrospinning to produce NiO:SnO nanofibers (NFs) for selectively reducing CO to formate above room temperature. The NFs comprise compact but disjoined NiO and SnO nanocrystals identified with STEM.

Recent advances in ionic thermoelectric systems and theoretical modelling.

Converting waste heat from solar radiation and industrial processes into useable electricity remains a challenge due to limitations of traditional thermoelectrics. Ionic thermoelectric (i-TE) materials offer a compelling alternative to traditional thermoelectrics due to their excellent ionic thermopower, low thermal conductivity, and abundant material options. This review categorizes i-TE materials into thermally diffusive and thermogalvanic types, with an emphasis on the former due to its superior thermopower.

Solution processable Si/Ge heterostructure NWs enabling anode mass reduction for practical full-cell Li-ion batteries.

Here, we report the solution phase synthesis of axial heterostructure Si and Ge (hSG) nanowires (NWs). The NWs were grown in a high boiling point solvent from a low-cost Sn powder to achieve a powder form product which represents an attractive route from lab-scale to commercial application. Slurry processed anodes of the NWs were investigated in half-cell ( Li-foil) and full-cell ( NMC811) configurations of a lithium ion battery (LIB).

Metal cation substitution can tune CO, HO and CH switching pressure in transiently porous coordination networks.

Compared to rigid physisorbents, switching coordination networks that reversibly transform between closed (non-porous) and open (porous) phases offer promise for gas/vapour storage and separation owing to their improved working capacity and desirable thermal management properties. We recently introduced a coordination network, X-dmp-1-Co, which exhibits switching enabled by transient porosity. The resulting "open" phases are generated at threshold pressures even though they are conventionally non-porous.

UPDATED PROTOCOL: Universal school-based programmes for improving social and emotional outcomes in children aged 3-11 years: An evidence and gap map.

This is the protocol for an evidence and gap map. The objective of this EGM is to identify and map all primary studies (including randomised and cluster randomised trials) and systematic reviews on universal, school-based social and emotional learning programmes for young children (3-11 years) to create a live, searchable, and publicly available evidence and gap map.

Supramolecular isomerism and structural flexibility in coordination networks sustained by cadmium rod building blocks.

Bifunctional N-donor carboxylate linkers generally afford and topology coordination networks of general formula ML that are based upon the MN(CO) molecular building block (MBB). Herein, we report on a new N-donor carboxylate linker, β-(3,4-pyridinedicarboximido)propionate (PyImPr), which afforded Cd(PyImPr) reaction of PyImPrH with Cd(acetate)·2HO. We observed that, depending upon whether Cd(PyImPr) was prepared by layering or solvothermal methods, 2D or 3D supramolecular isomers, respectively, of Cd(PyImPr) were isolated.

PROTOCOL: Group-based interventions for posttraumatic stress disorder: A systematic review and meta-analysis of the role of trauma type.

This is the protocol for a Campbell systematic review. The primary objective is to assess the effects of group-based treatments on posttraumatic stress disorder (PTSD) symptomology in people diagnosed with PTSD (by a clinician or screening instrument) or referred to a PTSD treatment group for their symptoms by a medical professional. We will also examine a range of moderators that may affect the efficacy of group-based treatments, including the nature of the trauma (interpersonal, stigmatized) and the group fit (in terms of gender and shared vs.

Melatonin improved glucose homeostasis is associated with the reprogrammed gut microbiota and reduced fecal levels of short-chain fatty acids in db/db mice.

Accumulated evidence shows that melatonin possesses the potential to improve lipid metabolism by modifying gut microbiota and glucose metabolism via regulating the melatonin receptor signaling pathway. However, the contribution of melatonin consumption on glucose homeostasis by affecting gut microbiota has not been investigated in diabetes. In the current work, we investigated the effect of melatonin administration on gut microbiota and glucose homeostasis in db/db mice, a type 2 diabetes model with leptin receptor deficiency.

Flow physics of planar bistable fluidic oscillator with backflow limbs.

Fluidic oscillators (FOs) are used in a variety of applications, including process control and process intensification. Despite the simple design and operation of FOs, the fluid dynamics of FOs exhibit rich complexities. The inherently unstable flow, jet oscillations, and resulting vortices influence mixing and other transport processes.

PROTOCOL: Case management interventions seeking to counter radicalisation to violence: A systematic review of tools and approaches.

This systematic review consists of two parts. Part I seeks to synthesise evidence from primary or secondary research studies examining the implementation and effectiveness of case management tools and approaches currently being used to counter radicalisation to violence. Part II is an 'overview of reviews' that seeks to identify relevant and transferable lessons from systematic reviews and meta-analyses of case management tools and approaches used in the broader field of violence prevention that could be applied to counter-radicalisation practice.

Quantitative surface free energy with micro-colloid probe pairs.

Measurement of the surface free energy (SFE) of a material allows the prediction of its adhesion properties. Materials can have microscale or sub-microscale surface inhomogeneities, engineered or random, which affect the surface macroscopic behaviour. However, quantitative characterization of the SFE at such length scales remains challenging in view of the variety of instruments and techniques available, the poor knowledge of critical variables and parameters during measurements and the need for appropriate contact models to derive the SFE from the measurements.

L-type Voltage-Gated calcium channels partly mediate Mechanotransduction in the intervertebral disc.

Background: Intervertebral disc (IVD) degeneration continues to be a major global health challenge, with strong links to lower back pain, while the pathogenesis of this disease is poorly understood. In cartilage, much more is known about mechanotransduction pathways involving the strain-generated potential (SGP) and function of voltage-gated ion channels (VGICs) in health and disease. This evidence implicates a similar important role for VGICs in IVD matrix turnover.

Biomedical applications of silk and its role for intervertebral disc repair.

Intervertebral disc (IVD) degeneration (IDD) is the main contributor to chronic low back pain. To date, the present therapies mainly focus on treating the symptoms caused by IDD rather than addressing the problem itself. For this reason, researchers have searched for a suitable biomaterial to repair and/or regenerate the IVD.

Growing leaders from below: Identity-based worker education and identity-leader ability among self-employed women in India.

Informal and unregulated work is the norm rather than the exception in emerging economies. This study was conducted in India where nine out of 10 women are occupied in informal, unregulated work, and are vulnerable to low-wages, exploitation, and interconnected cultural and social-economic injustices. The Self-Employed Women's Association (SEWA) and their education wing the Indian Academy of Self-Employed Women encourage their members to self-define as "self-employed workers" and facilitate identity-based worker education and leadership training.

A digital therapeutic for management of psychosocial aspects of psoriasis: A pre-post proof of concept study.

Background: Despite the psychosocial challenges of living with psoriasis many patients may not be able to access appropriate services to manage these challenges. Mobile health interventions may be helpful as a means to support patients in managing the impact of their condition.

Objective: To conduct a preliminary examination of the feasibility and acceptability of a bespoke psoriasis-specific digital therapeutic solution (hereafter termed ), and to provide initial data on psychological changes pre-post.

Catalytic valorisation of biomass levulinic acid into gamma valerolactone using formic acid as a H donor: a critical review.

This review sheds light on the catalytic valorisation of agroforestry biomass through levulinic acid and formic acid towards γ-valerolactone and other higher-value chemicals. γ-Valerolactone is produced by the hydrogenation of levulinic acid, which can be achieved through an internal hydrogen transfer reaction with formic acid in the presence of catalyst. By reviewing corresponding catalysts, the paper underlines the most efficient steps constituting an integrated sustainable process that eliminates the need for external H sources while producing biofuels as an alternative energy source.