Perfusion CT allows prediction of therapy response in non-small cell lung cancer treated with conventional and anti-angiogenic chemotherapy.

Objectives: To determine whether CT can depict early perfusion changes in lung cancer treated by anti-angiogenic drugs, allowing prediction of response.

Methods: Patients with non-small cell lung cancer, treated by conventional chemotherapy with (Group 1; n = 17) or without (Group 2; n = 23) anti-vascular endothelial growth factor (anti-VEGF) drug (bevacizumab) underwent CT perfusion before (TIME 0) and after 1 (TIME 1), 3 (TIME 2) and 6 (TIME 3) cycles of chemotherapy. The CT parameters evaluated included: (1) total tumour vascular volume (TVV) and total tumour extravascular flow (TEF); (2) RECIST (Response Evaluation Criteria in Solid Tumours) measurements.

The mutual roles of action representations and spatial deictics in French language.

Many aspects of language associated with an object's noun inform about the location of the object the noun refers to, in relation to the action system. In the present study, we tested whether the determiners la (the) and cette (that) in French language carry embodied spatial information. In Experiment 1, participants performed a reachability judgement task after having evaluated the correct spelling of both a determiner (la or cette) and an object-noun (balle-ball, tasse-cup, or pomme-apple).

Mechanisms of splenic hypertrophy following hepatic resection.

Background: Following hepatic resection, liver regeneration has been associated with concurrent splenic hypertrophy. The mechanisms of this phenomenon are unknown, may be multiple and include: splanchnic sequestration caused by a reduction in the hepatic mass; hepatic growth factors that may indirectly act on the spleen, and the redistribution of the total reticuloendothelial system.

Methods: Seventy-five patients (40 males; median age: 60 years) who underwent minor (16%) or major (84%) hepatectomy between September 2004 and October 2009 were included.

Novel conformationally constrained analogues of agomelatine as new melatoninergic ligands.

Novel conformationally restricted analogues of agomelatine were synthesized and pharmacologically evaluated at MT₁ and MT₂ melatoninergic receptors. Replacement of the N-acetyl side chain of agomelatine by oxathiadiazole-2-oxide (compound 3), oxadiazole-5(4H)-one (compound 4), tetrazole (compound 5), oxazolidinone (compound 7a), pyrrolidinone (compound 7b), imidazolidinedione (compound 12), thiazole (compounds 13 and 14) and isoxazole moieties (compound 15) led to a decrease of the melatoninergic binding affinities, particularly at MT₁. Compounds 7a and 7b exhibiting nanomolar affinity towards the MT₂ receptors subtypes have shown the most interesting pharmacological results of this series with the appearance of a weak MT₂-selectivity.

Ischemic gastritis: a rare but lethal consequence of celiac territory ischemic syndrome.

Aim: Ischemic gastritis is poorly known by physicians and is often fatal if not correctly diagnosed. Here, we report on the clinical, endoscopic and imaging features and treatment outcomes for five ischemic gastritis patients.

Methods: This was a retrospective, single-centre study of patients treated for ischemic gastritis between January 2009 and April 2012.

Physical performance and subjective ratings after a soccer-specific exercise simulation: comparison of natural grass versus artificial turf.

This study aimed to compare the recovery kinetics of physical performance and subjective ratings in response to a soccer-specific exercise simulation on natural grass and artificial turf. Physical performance tests and subjective ratings were assessed on 13 professional soccer players before, immediately after, 24 h and 48 h after the test. Physical performance tests included squat jump, countermovement jump, 6-s sprint on a non-motorised treadmill and isokinetic eccentric hamstring assessment (2.

Memantine for axial signs in Parkinson's disease: a randomised, double-blind, placebo-controlled pilot study.

Background: Given that memantine is thought to decrease N-methyl-D-aspartic-acid-related (NMDA) glutamatergic hyperactivity and improve locomotion in rats, we sought to assess the drug's impact on axial symptoms in advanced Parkinson's disease (PD).

Methods: We performed a 90-day, randomised, double-blind, study with two parallel arms: 20 mg/day memantine versus placebo (ClinicalTrials.gov:NCT01108029).

The supinator muscle: anatomical bases for deep branch of the radial nerve entrapment.

Purpose: Our goals were to carry out an anatomical description of the internal architecture of the supinator muscle in order to describe potentially compressive structures for the deep branch of the radial nerve (DBRN) and to establish reference landmarks for the surgical treatment of radial tunnel syndrome.

Methods: Thirty upper limbs were dissected. The pennation angle of proximal and distal arcades of the supinator to the radial shaft axis was measured.

Heavy alcohol intake and intracerebral hemorrhage: characteristics and effect on outcome.

Objectives: To identify associated factors and influence on long-term outcome of heavy alcohol intake in a large prospective cohort of consecutive patients with a spontaneous intracerebral hemorrhage (ICH).

Methods: Between November 2004 and March 2009, we prospectively recruited 562 consecutive adults with a spontaneous ICH. We excluded patients without information on drinking habit (n = 22).

Embodied perception of reachable space: how do we manage threatening objects?

This study aimed at determining whether the size of reachable space is affected by the level of danger of some everyday manipulable objects. Two possibilities are examined: Dangerous objects affect the size of reachable space because of long-term semantic knowledge of their potential hurtful value or the on-line relation between objects' dangerous attributes and the body. The experimental paradigm combined the danger value (dangerous/not dangerous) and the orientation of objects (e.

Enhancing field GP engagement in hospital-based studies. Rationale, design, main results and participation in the Diagest 3-GP motivation study.

Background: Diagest 3 was a study aimed at lowering the risk of developing type 2 diabetes within 3 years after childbirth. Women with gestational diabetes were enrolled in the study. After childbirth, the subjects showed little interest in the structured education programme and did not attend workshops.

Ultrafast imaging of the entire chest without ECG synchronisation or beta-blockade: to what extent can we analyse the coronary arteries?

Objectives: To evaluate the accessibility of coronary arteries from chest CT examinations acquired without ECG gating or beta-blockade.

Materials And Methods: Two hundred forty-two patients (median heart rate: 81.7 bpm) underwent a non-ECG-gated CT examination with high pitch and high temporal resolution.

Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study.

Background: Treatment options for patients suffering from progressive forms of multiple sclerosis (MS) remain inadequate. Mast cells actively participate in the pathogenesis of MS, in part because they release large amounts of various mediators that sustain the inflammatory network. Masitinib, a selective oral tyrosine kinase inhibitor, effectively inhibits the survival, migration and activity of mast cells.

Anticipatory postural adjustments during step initiation: elicitation by auditory stimulation of differing intensities.

Step initiation is associated with anticipatory postural adjustments (APAs) that vary according to the speed of the first step. When step initiation is elicited by a "go" signal (i.e.

Role of basal ganglia circuits in resisting interference by distracters: a swLORETA study.

Background: The selection of task-relevant information requires both the focalization of attention on the task and resistance to interference from irrelevant stimuli. Both mechanisms rely on a dorsal frontoparietal network, while focalization additionally involves a ventral frontoparietal network. The role of subcortical structures in attention is less clear, despite the fact that the striatum interacts significantly with the frontal cortex via frontostriatal loops.

A multibiomarker approach in juvenile turbot, Scophthalmus maximus, exposed to contaminated sediments.

Juvenile turbot were exposed in laboratory conditions to a mixture of chemical contaminants associated with harbour and estuarine sediments for seven and 21 days. Several molecular biomarkers of exposure were then measured in fish liver: two biotransformation parameters [ethoxyresorufin-O-deethylase (EROD) and phase II glutathione S-transferase (GST) activities] and an antioxidant enzyme activity [catalase (CAT)]. Modifications at the histological level were analysed by the measurement of the number and size of melanomacrophage centres (MMCs) and disturbances to the immune function by the measurement of cytokine transforming growth factor-beta (TGF-β) and development of the thymus.

980-nm laser lipolysis (LAL): About 674 procedures in 359 patients.

Background: Since the first studies by Apfelberg in 1994, laser lipolysis (LAL) has been on the rise. Laser lipolysis leads to reduced operator fatigue, excellent patient tolerance, quick recovery time, as well as the additional benefit of dermal tightening. This article reports a 5-year experience of LAL and underlines the potential evolutions of the technique.

Surgery in esophageal and gastric cancer patients: what is the role for nutrition support in your daily practice?

Cancers of the esophagus and stomach have a major impact on patients' nutritional status by virtue of these organs' inherent digestive functions. Many patients with these cancers will require surgical intervention, which imposes further metabolic demands and compounds preexisting nutritional disorders. Patients with esophagogastric cancer are likely to have lost weight by the time the diagnosis is made.

General molecular biology and architecture of nuclear receptors.

Nuclear receptors (NRs) regulate and coordinate multiple processes by integrating internal and external signals, thereby maintaining homeostasis in front of nutritional, behavioral and environmental challenges. NRs exhibit strong similarities in their structure and mode of action: by selective transcriptional activation or repression of cognate target genes, which can either be controlled through a direct, DNA binding-dependent mechanism or through crosstalk with other transcriptional regulators, NRs modulate the expression of gene clusters thus achieving coordinated tissue responses. Additionally, non genomic effects of NR ligands appear mediated by ill-defined mechanisms at the plasma membrane.

Cladribine tablets for relapsing-remitting multiple sclerosis: Efficacy across patient subgroups from the phase III CLARITY study.

Background: In the phase III CLARITY study, treatment with cladribine tablets at cumulative doses of 3.5 or 5.25mg/kg over 96 weeks led to significant reductions in annualized relapse rates (ARR) versus placebo in patients with relapsing-remitting multiple sclerosis.

Influence of social factors on weight-related behaviors according to gender in the French adult population.

Although the prevalence of obesity is higher in low socioeconomic position (SEP), the relationship between SEP and body mass index (BMI) differs according to gender. The purpose of this study is to investigate the relationships between BMI and SEP according to gender and explore the weight-related behaviors. In a cross-sectional survey, 1646 French adults were weighed and answered a questionnaire about eating behavior (DEBQ), SEP markers, ideal weight perception, physical activity and smoking.

Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1 activity and is essential for parasitic survival.

Growing evidence indicates that the protein regulators governing protein phosphatase 1 (PP1) activity have crucial functions because their deletion drastically affects cell growth and division. PP1 has been found to be essential in Plasmodium falciparum, but little is known about its regulators. In this study, we have identified a homolog of Inhibitor-3 of PP1, named PfI3.