91 results match your criteria: "University of Leuven K.U.Leuven[Affiliation]"

The root-knot nematode Meloidogyne incognita poses a worldwide threat to agriculture, with an increasing demand for alternative control options since most common nematicides are being withdrawn due to environmental concerns. The biocontrol potential of arbuscular mycorrhizal fungi (AMF) against plant-parasitic nematodes has been demonstrated, but the modes of action remain to be unraveled. In this study, M.

View Article and Find Full Text PDF

The construction of perceptual grouping displays using GERT.

Behav Res Methods

June 2012

Laboratory of Experimental Psychology, University of Leuven (K.U. Leuven), Tiensestraat 102, bus 3711, 3000, Leuven, Belgium.

To study perceptual grouping processes, vision scientists often use stimuli consisting of spatially separated local elements that, together, elicit the percept of a global structure. We developed a set of methods for constructing such displays and implemented them in an open-source MATLAB toolbox, GERT (Grouping Elements Rendering Toolbox). The main purpose of GERT is to embed a contour in a field of randomly positioned elements, while avoiding the introduction of a local density cue.

View Article and Find Full Text PDF

Chronic inflammation may increase the risk to develop cancer, for instance esophagitis or gastritis may lead to development of esophageal or gastric cancer, respectively. The key molecules attracting leukocytes to local inflammatory sites are chemokines. We here provide a systematic review on the impact of CXC chemokines (binding the receptors CXCR1, CXCR2, CXCR3 and CXCR4) on the transition of chronic inflammation in the upper gastrointestinal tract to neoplasia.

View Article and Find Full Text PDF

The expression and role of CXC chemokines in colorectal cancer.

Cytokine Growth Factor Rev

April 2012

Laboratory of Molecular Immunology, Rega Institute for Medical Research, University of Leuven (K.U. Leuven), Minderbroedersstraat 10, B-3000 Leuven, Belgium.

Cancer is a life-threatening disease world-wide and colorectal cancer is the second common cause of cancer mortality. The interaction between tumor cells and stromal cells plays a crucial role in tumor initiation and progression and is partially mediated by chemokines. Chemokines predominantly participate in the chemoattraction of leukocytes to inflammatory sites.

View Article and Find Full Text PDF

The human visual system is highly sensitive to biological motion and manages to organize even a highly reduced point-light stimulus into a vivid percept of human action. The current study investigated to what extent the origin of this saliency of point-light displays is related to its intrinsic Gestalt qualities. In particular, we studied whether biological motion perception is facilitated when the elements can be grouped according to good continuation and similarity as Gestalt principles of perceptual organization.

View Article and Find Full Text PDF

The rodent pituitary gland undergoes prominent maturation during the first weeks after birth, including a well-known increase in hormone-producing cells. In the past, it has frequently been postulated that stem cells are involved in this early-postnatal growth phase. This hypothesis can now be explored, as pituitary stem/progenitor cells were recently identified.

View Article and Find Full Text PDF

We investigated how the electrophysiological signature of contour integration is changed by the context in which a contour is embedded. Specifically, we manipulated the orientations of Gabor elements surrounding an embedded shape outline. The amplitudes of early visual components over posterior scalp regions were changed by the presence of a contour, and by the orientation of elements surrounding the contour.

View Article and Find Full Text PDF

Transition-metal-free oxides were studied as heterogeneous catalysts for the sustainable epoxidation of alkenes with aqueous H₂O₂ by means of high throughput experimentation (HTE) techniques. A full-factorial HTE approach was applied in the various stages of the development of the catalysts: the synthesis of the materials, their screening as heterogeneous catalysts in liquid-phase epoxidation and the optimisation of the reaction conditions. Initially, the chemical composition of transition-metal-free oxides was screened, leading to the discovery of gallium oxide as a novel, active and selective epoxidation catalyst.

View Article and Find Full Text PDF

μ-Conotoxin KIIIA from Conus kinoshitai is a 16-residue peptide that acts as a potent pore blocker of several voltage-gated sodium channels (Na(v)). In order to obtain more selective blockers and to investigate the role of Trp at position 8, we substituted this residue with Arg, Gln and Glu. KIIIA and analogues were tested on a range of Na(v) expressed in Xenopus laevis oocytes.

View Article and Find Full Text PDF

Generalization of visual shapes by flexible and simple rules.

Seeing Perceiving

September 2012

Laboratory of Experimental Psychology, University of Leuven (K.U. Leuven), Tiensestraat 102, P.O. Box 3711, B-3000 Leuven, Belgium.

Rules and similarity are at the heart of our understanding of human categorization. However, it is difficult to distinguish their role as both determinants of categorization are confounded in many real situations. Rules are based on a number of identical properties between objects but these correspondences also make objects appearing more similar.

View Article and Find Full Text PDF

In our commentary paper (Dry, Kogo, Putzeys, & Wagemans, 2010) on 'The utility of image descriptions in the initial stages of vision: a case study of printed text' (Watt & Dakin, 2010a), we raised a few concerns about the approach to perceptual grouping proposed by Watt and Dakin. Specifically, we argued that the 'overlap tokens' resulting from convolution with Gabor filters do not reflect the global configuration of the image and hence that they would not be able to reproduce cases of context-sensitive perception such as illusory contours in the Kanizsa image. In their reply to our commentary, Watt and Dakin (2010b) showed that the responses of their model do reflect the illusory contours.

View Article and Find Full Text PDF

Human observers explore scenes by shifting their gaze from object to object. Before each eye movement, a peripheral glimpse of the next object to be fixated has however already been caught. Here we investigate whether the perceptual organization extracted from such a preview could guide the perceptual analysis of the same object during the next fixation.

View Article and Find Full Text PDF

Some of the brain areas in the ventral temporal lobe, such as the fusiform face area (FFA), are critical for face perception in humans, but what determines this specialization is a matter of debate. The face specificity hypothesis claims that faces are processed in a domain-specific way. Alternatively, the expertise hypothesis states that the FFA is specialized in processing objects of expertise.

View Article and Find Full Text PDF

Dynamic prototypicality effects in visual search.

J Exp Psychol Gen

August 2011

Laboratory of Experimental Psychology, University of Leuven (K. U. Leuven), Tiensestraat 102, Bus 3711, B-3000 Leuven, Belgium.

In recent studies, researchers have discovered a larger neural activation for stimuli that are more extreme exemplars of their stimulus class, compared with stimuli that are more prototypical. This has been shown for faces as well as for familiar and novel shape classes. We used a visual search task to look for a behavioral correlate of these findings regarding both simple geometrical shapes and more complex, novel shape classes.

View Article and Find Full Text PDF

Sea anemone venom is a known source of interesting bioactive compounds, including peptide toxins which are invaluable tools for studying structure and function of voltage-gated potassium channels. APEKTx1 is a novel peptide isolated from the sea anemone Anthopleura elegantissima, containing 63 amino acids cross-linked by 3 disulfide bridges. Sequence alignment reveals that APEKTx1 is a new member of the type 2 sea anemone peptides targeting voltage-gated potassium channels (K(V)s), which also include the kalicludines from Anemonia sulcata.

View Article and Find Full Text PDF

Object knowledge is hierarchical. Several hypotheses have proposed that this property might be reflected in the spatial organization of ventral visual cortex. For example, all exemplars of a category might activate the same patches of cortex, but with a slightly different position of the peak of activation in each patch.

View Article and Find Full Text PDF

Preschool impairments in auditory processing and speech perception uniquely predict future reading problems.

Res Dev Disabil

June 2011

Parenting and Special Education Research Group, ExpORL, Department of Neurosciences, University of Leuven (K.U. Leuven), Herestraat 49-Box 721, 3000 Leuven, Belgium.

Developmental dyslexia is characterized by severe reading and spelling difficulties that are persistent and resistant to the usual didactic measures and remedial efforts. It is well established that a major cause of these problems lies in poorly specified phonological representations. Many individuals with dyslexia also present impairments in auditory temporal processing and speech perception, but it remains debated whether these more basic perceptual impairments play a role in causing the reading problem.

View Article and Find Full Text PDF

Towards a new kind of experimental psycho-aesthetics? Reflections on the Parallellepipeda project.

Iperception

November 2012

University of Leuven (K.U. Leuven), Laboratory of Experimental Psychology, Tiensestraat 102-box 3711, BE-3000 Leuven, Belgium; e-mail:

Experimental psycho-aesthetics-the science aimed at understanding the factors that determine aesthetic experience-is reviewed briefly as background to describe the Parallellepipeda project, a cross-over project between artists and scientists in Leuven. In particular, I sketch how it started and developed further, with close interactions between the participating artists and scientists. A few examples of specific research projects are mentioned to illustrate the kind of research questions we address and the methodological approach we have taken.

View Article and Find Full Text PDF

Depth.

Iperception

November 2012

University of Leuven (K.U. Leuven), Laboratory of Experimental Psychology, Tiensestraat 102-box 3711, BE-3000 Leuven, Belgium, and Delft University of Technology, EEMCS, MMI, Mekelweg 4, NL-2628 CD Delft, The Netherlands; e-mail:

Depth is the feeling of remoteness, or separateness, that accompanies awareness in human modalities like vision and audition. In specific cases depths can be graded on an ordinal scale, or even measured quantitatively on an interval scale. In the case of pictorial vision this is complicated by the fact that human observers often appear to apply mental transformations that involve depths in distinct visual directions.

View Article and Find Full Text PDF

Development of differential sensitivity for shape changes resulting from linear and nonlinear planar transformations.

Iperception

November 2012

Laboratory of Experimental Psychology, University of Leuven (K.U. Leuven), Tiensestraat 102, box 3711, BE-3000 Leuven, Belgium; e-mail:

A shape bias for extending names to objects that look visually similar has been commonly accepted but it is hard to define which kind of shape dissimilarities are diagnostic for the identity of an object. Here, we present a transformational approach to describe shape differences that can incorporate many significant shape features. We introduce two kinds of transformations: one kind concerns linear transformations of the image plane (affine transformations), generally limiting shape variations within the borders of basic-level categories; the other kind concerns nonlinear continuous transformations of the image plane (topological transformations), allowing all kinds of shape variation crossing and not crossing the borders of basic-level categories.

View Article and Find Full Text PDF

Pituitary stem/progenitor cells: embryonic players in the adult gland?

Eur J Neurosci

December 2010

Laboratory of Tissue Plasticity, Department of Molecular Cell Biology, University of Leuven (K.U.Leuven), B-3000 Leuven, Belgium.

The pituitary gland represents the endocrine core of the body, and its hormonal output governs many key physiological processes. Because endocrine demands frequently change, the pituitary has to flexibly remodel its hormone-producing cell compartment. One mechanism of pituitary plasticity may rely on the generation of new hormonal cells from resident stem/progenitor cells.

View Article and Find Full Text PDF

One of the most important tasks of the visual system is the extraction of edges and object contours, and the integration of discrete elements to form a coherent global percept. A great deal is known about the spatial properties of contour extraction, but less is known about the dynamics and spatio-temporal aspects. We used Gabor-rendered outlines of real-world objects, where we could manipulate low-level properties, such as element orientation and phase, while incorporating higher-level properties, such as object complexity and identity, to study dynamic relationships in object detection.

View Article and Find Full Text PDF

Previous studies have argued that faces and other objects are encoded in terms of their deviation from a class prototype or norm. This prototype is associated with a smaller neural population response compared with nonprototype objects. However, it is still unclear (1) whether a norm-based representation can emerge for unfamiliar or novel object classes through visual experience at the time scale of an experiment and (2) whether the results from previous studies are caused by the prototypicality of a stimulus, by the physical properties of individual stimuli independent from the stimulus distribution, and/or by the trial-to-trial adaptation.

View Article and Find Full Text PDF

Study Design: A 2-group experimental design.

Objective: To determine postural stability and proprioceptive postural control strategies of healthy subjects and subjects with recurrent low back pain (LBP) during acute inspiratory muscles fatigue (IMF).

Summary Of Background Data: People with LBP use a more rigid proprioceptive postural control strategy than control subjects during postural perturbations.

View Article and Find Full Text PDF