Underestimated associated features in CMT neuropathies: clinical indicators for the causative gene?

Introduction: Charcot-Marie-Tooth neuropathy (CMT) is a genetically heterogeneous group of peripheral neuropathies. In addition to the classical clinical phenotype, additional features can occur.

Methods: We studied a wide range of additional features in a cohort of 49 genetically confirmed CMT patients and performed a systematic literature revision.

Low-Cost Avoidance Behaviors are Resistant to Fear Extinction in Humans.

Elevated levels of fear and avoidance are core symptoms across the anxiety disorders. It has long been known that fear serves to motivate avoidance. Consequently, fear extinction has been the primary focus in pre-clinical anxiety research for decades, under the implicit assumption that removing the motivator of avoidance (fear) would automatically mitigate the avoidance behaviors as well.

Holistic processing of human body postures: evidence from the composite effect.

The perception of socially relevant stimuli (e.g., faces and bodies) has received considerable attention in the vision science community.

Combinatorial brain decoding of people's whereabouts during visuospatial navigation.

Complex behavior typically relies upon many different processes which are related to activity in multiple brain regions. In contrast, neuroimaging analyses typically focus upon isolated processes. Here we present a new approach, combinatorial brain decoding, in which we decode complex behavior by combining the information which we can retrieve from the neural signals about the many different sub-processes.