4,462 results match your criteria: "University of Lagos[Affiliation]"
Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans.
N Engl J Med
October 2024
From the Department of Pediatrics, Duke University Medical Center, Durham (R.A.G.), and the Departments of Medicine (B.I.F.) and Biochemistry (N.D.P.), Wake Forest University School of Medicine, Winston-Salem - both in North Carolina; the Department of Medicine, University of Nigeria, Nsukka (I.U.), the Department of Medicine, College of Medicine, University of Ibadan, Ibadan (S. Ajayi, Y.R., A.D.A., A. Asinobi, O. Amodu, B.L.S.), the Department of Medicine, University of Ilorin, Ilorin (T.O.), the Department of Medicine, Obafemi Awolowo University, Ile-Ife (F.A.), the Department of Medicine, University of Abuja, Abuja, Nigeria (M. Mamven), the Department of Medicine, College of Medicine, University of Lagos, Lagos (T.A.), the Department of Medicine, College of Medicine, Lagos State University, Ojo (A.S., O. Awobusuyi), the Department of Medicine, Usmanu Danfodiyo University, Sokoto (M. Makusidi), Nnamdi Azikiwe University Teaching Hospital, Nnewi (U.O.), Delta State University Teaching Hospital, Oghara (O.O.), and Aminu Kano Teaching Hospital, Kano (A. Abdu) - all in Nigeria; the Department of Medicine, University of Ghana Medical School (C.O., M. Matekole, V.A., V.B., D.A.), and Noguchi Memorial Institute for Medical Research, University of Ghana (A.N., A.G.), Accra, the Department of Medicine, University of Cape Coast, Cape Coast (I.E.), and Kwame Nkrumah University of Science and Technology, Kumasi (J.P.-R., S. Antwi) - all in Ghana; the Basic Research Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick (C.A.W.), the Center for Research on Genomics and Global Health, National Human Genome Research Institute (A.A.A.), and the Division of Kidney, Urologic and Digestive Disease, National Institute of Diabetes and Digestive Kidney Diseases (P.L.K.), National Institutes of Health, Bethesda - all in Maryland; the Departments of Human Genetics (D.B.), Medicine (M.K.), and Pathology (J.B.H.), University of Michigan Medical School, Ann Arbor; the Parkinson School of Health Sciences and Public Health, Loyola University, Chicago (R.C., B.T.); the Department of Medicine, Boston University School of Medicine (T.O.I.), the Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School (M.R.P.), and the Departments of Pathology (B.C.) and Medicine (W.W.), Massachusetts General Hospital and Harvard Medical School - all in Boston; the Department of Medicine, College of Medicine, University of Arizona, Tucson (F.C.B.); the Departments of Biostatistics and Data Science (M.P., J.S.) and Medicine (C.I.A., J.W., A.O.), University of Kansas Medical Center, Kansas City, Kansas; and the Department of Medicine and Pediatrics, Women's College Hospital, Hospital for Sick Children and University of Toronto, Toronto (R.S.P.).
Background: Apolipoprotein L1 gene () variants are risk factors for chronic kidney disease (CKD) among Black Americans. Data are sparse on the genetic epidemiology of CKD and the clinical association of variants with CKD in West Africans, a major group in the Black population.
Methods: We conducted a case-control study involving participants from Ghana and Nigeria who had CKD stages 2 through 5, biopsy-proven glomerular disease, or no kidney disease.
Inequalities in geographical access to emergency obstetric and newborn care.
Bull World Health Organ
November 2024
Department of Obstetrics and Gynaecology, College of Medicine of the University of Lagos, Lagos, Nigeria.
Navigating Food Fraud: A Survey of Nigerian Consumer Knowledge and Attitudes.
Foods
October 2024
Department of Microbiology, University of Medical Sciences, Ondo City 351103, Nigeria.
Article Synopsis
- - Food fraud is a significant global issue affecting health, safety, and brand trust, primarily driven by economic gain through the intentional adulteration of food products.
- - A study of 2,160 Nigerians revealed that while many are not familiar with the term "food fraud," they recognize specific local cases and rely on point-of-sale information to assess food authenticity, particularly wary of street vendors.
- - Concerns about food fraud are widespread, with common items identified as vulnerable to fraud including dairy, honey, and rice, indicating a pressing need for better consumer education and regulatory measures in Nigeria.
Article Synopsis
- The study analyzed global, regional, and national trends in injury burden and identified risk factors contributing to injuries using data from the GBD 2019.
- In 2019, there were approximately 713.9 million injury incidents and 4.3 million injury-related deaths globally, with low bone mineral density emerging as the leading risk factor.
- The findings emphasize the need for effective global injury prevention policies by highlighting the persistent impact of injuries on global health.
Uncovering the genetic basis of Parkinson's disease globally: from discoveries to the clinic.
Lancet Neurol
December 2024
Institute of Neurogenetics, University of Luebeck, Luebeck, Germany; Department of Neurology, University of Luebeck and University Hospital Schleswig-Holstein, Luebeck, Germany.
Article Synopsis
- Knowledge of the genetic factors contributing to Parkinson's disease has significantly expanded, starting from the identification of the first mutation in α-synuclein to discovering various other related genes.
- Genetic research helps understand the diverse symptoms of Parkinson's disease and promotes the search for new biomarkers and treatment options, with several clinical trials in progress.
- Efforts to include previously under-represented populations in genetic studies are fostering collaboration and promising new insights, although challenges persist, offering opportunities for a more comprehensive understanding of the disease worldwide.
A systematic analysis of neurologic manifestations of Long COVID in Nigeria.
J Neurovirol
October 2024
Department of Medicine, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi Araba, Lagos State, Nigeria.
Long COVID, also called post-acute sequelae of SARS-CoV-2 infection (PASC) affects millions of people in the world. The neurologic manifestations of PASC (Neuro-PASC) are among the most debilitating but they are largely unreported in Africa. We sought to compare the demographics, symptoms and cognitive profile of post-hospitalization Neuro-PASC (PNP) and non-hospitalized Neuro-PASC (NNP) patients in Nigeria.
View Article and Find Full Text PDFCryptogenic Organizing Pneumonia Is Associated With Increased Mortality Risk in Hospitalizations for Systemic Lupus Erythematosus (SLE): A National Inpatient Sample Analysis.
Cureus
September 2024
Internal Medicine, Regions Stroke and Neuroscience Hospital, Owerri, NGA.
Background This study analyzed the incidence, characteristics, and mortality risk associated with cryptogenic organizing pneumonia (COP) among hospitalizations for systemic lupus erythematosus (SLE) with lung involvement. Methods Adult hospitalizations from the 2016-2020 nationwide inpatient sample were analyzed using relevant International Classification of Diseases (ICD)-10 codes for SLE with lung involvement (M32.13) and COP (J84.
View Article and Find Full Text PDFAdvanced-technique radiation therapy for nasopharyngeal carcinoma in a low resource setting: a review of treatment-related quality of life.
Ecancermedicalscience
September 2024
NSIA -LUTH Cancer Centre, Lagos University Teaching Hospital, Lagos 100001, Nigeria.
Background: Nasopharyngeal carcinoma (NPC) is a rare but significant public health concern, especially in Africa, with a rising global incidence. This study aimed to investigate the pattern of presentation, treatment outcomes and impact on health-related quality of life (HRQOL) of NPC patients at a tertiary institution in Lagos, Nigeria.
Methodology: A retrospective review of all nasopharyngeal cancer patients ( = 125) treated at a tertiary centre in Lagos, Nigeria, from May 2019 to 2022 was done.
New insights on pharmacological and therapeutic potentials of trimetazidine beyond anti-anginal drug: A comprehensive review.
Eur J Pharmacol
December 2024
Department of Pharmacology, Therapeutics & Toxicology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba, P.M.B. 12003, Lagos, Nigeria. Electronic address:
Trimetazidine (TMZ) is a beneficial and well-tolerable anti-anginal drug which has protective action towards ischemia and reperfusion injury. TMZ performs its anti-ischemic effect by modifying cardiac metabolism without shifting the hemodynamic functions, so it represents an outstanding complementary perspective to the general angina treatment. TMZ possesses a positive impact on the inflammatory profile, and also endothelial function furthermore displays various benefits through minimising the number, as well as the intensity of angina strikes and ameliorating the clinical indication and symptoms of myocardium ischemia.
View Article and Find Full Text PDFRetraction Note: Technological innovations, renewable energy, globalization, financial development, and carbon emissions: role of inward remittances for top ten remittances receiving countries.
Environ Sci Pollut Res Int
November 2024
Department of Economics, Faculty of Economics and Administrative Sciences, Cyprus International University, Via Mersin 10, Haspolat, Turkey.
Improving death notification and registration: A pilot project in Lagos state, Nigeria.
J Glob Health
October 2024
Department of Anatomic and Molecular Pathology, University of Lagos, Lagos State, Nigeria.
Impact of obesity on survival outcomes of women with advanced epithelial ovarian cancer in Lagos, Nigeria: a retrospective cohort study.
Ecancermedicalscience
August 2024
Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, PMB 12003, Surulere, Lagos, Nigeria.
Background: Epithelial ovarian cancer (EOC) is a major contributor to cancer-related illness and death among women worldwide. Obesity, a prevalent condition in many populations, has been implicated as a risk factor for various malignancies including EOC.
Objectives: This study investigated the impact of obesity on survival outcomes among women with advanced EOC in Lagos, Nigeria.
Urban public space initiatives and health in Africa: A mixed-methods systematic review.
PLOS Glob Public Health
October 2024
Global Diet and Activity Research Group and Network, MRC Epidemiology Unit, University of Cambridge, United Kingdom.
Article Synopsis
- Public space initiatives (PSIs) in African cities can improve health and social well-being, but there's a lack of research on their effectiveness and implementation across the continent.
- This study synthesizes existing literature to assess the characteristics, locations, and outcomes of PSIs, finding that sports initiatives are predominant and that most research comes from South Africa.
- Key challenges for PSIs include limited funding, historical marginalization, and competing land uses, highlighting the need for long-term evaluations and better collaboration for sustainable health-promoting public spaces.
Point-of-care biochemistry for primary healthcare in low-middle income countries: a qualitative inquiry.
BMC Prim Care
October 2024
Department of Child Dental Health, Obafemi Awolowo University, Ile-Ife, Nigeria.
Article Synopsis
- * Conducted in Mongolia, Nigeria, and Peru, the research involved conversations with healthcare decision-makers, professionals, and community advocates to gather insights on the importance of PoC biochemistry in improving healthcare access and outcomes.
- * Most participants recognized that PoC biochemistry could enhance clinical decision-making and save resources, particularly benefiting vulnerable populations, while also aiding in the management of chronic and infectious diseases.
Challenges in Diagnosis and Management of SLE in Africa: An Online Survey.
ACR Open Rheumatol
October 2024
Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, South Africa.
Article Synopsis
- * Results showed that while many lab tests and medications were available, there were significant regional differences in access, particularly in East and West Africa.
- * Key issues identified included long turnaround times for test results and patients often having to self-fund medical expenses, which hindered timely diagnosis and treatment.
A Deep Learning System to Predict Epithelial Dysplasia in Oral Leukoplakia.
J Dent Res
November 2024
Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong SAR, China.
Article Synopsis
- Oral leukoplakia (OL) can lead to oral cancer, especially when accompanied by epithelial dysplasia (OED), making accurate assessment crucial but difficult.
- This study developed a deep learning (DL) model using oral photographs to predict the likelihood of dysplasia and compared its performance against human clinicians.
- Results showed that the DL model performed well, with higher accuracy than the majority of human raters and potential benefits in guiding biopsy decisions, indicating it could effectively assist in assessing dysplasia in patients with leukoplakia.
A perspective on inequities in the management of radiation dermatitis.
Asia Pac J Oncol Nurs
October 2024
Departments of Dermatology & Radiation Oncology, University of Rochester Medical Center, Rochester, NY, USA.
Mitigative role of cysteamine against unilateral renal reperfusion injury in Wistar rats.
Front Pharmacol
September 2024
Department of Biochemistry, University of Lagos, Lagos, Nigeria.
Background: Ischemia-reperfusion injury (IRI) is unavoidable during kidney transplant and it is responsible for delayed or non-function after kidney transplantation. Cysteamine is the standard drug in the management of nephropathic cystinosis and its extra-renal complications. Thus, we designed this study to investigate its potential against renal reperfusion injury.
View Article and Find Full Text PDFArticle Synopsis
- * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
- * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
Adverse Events Following Immunization with Novel Oral Polio Vaccine Type 2, and the Experience and Challenges of Reporting in Sierra Leone [Response to Letter].
Drug Healthc Patient Saf
September 2024
Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos, Lagos, Nigeria.
Impact of Cancer Across the Intergenerational Family: A Multidimensional Perspective From African Countries.
JCO Glob Oncol
September 2024
Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France.
Improving National and International Surveillance of Movement Behaviours in Childhood and Adolescence: An International Modified Delphi Study.
Sports Med
October 2024
Active Healthy Kids Global Alliance, Healthy Active Living and Obesity Research, Ottawa, Canada.
Article Synopsis
- The study aimed to improve global surveillance of child and adolescent movement behaviors (like physical activity and screen time) by gathering expert opinions through a Delphi method involving 62 participants.
- Experts ranked important items in categories like funding, capacity building, and methods, with a consensus on key priorities such as increased public funding and standard protocols for measures.
- The findings highlighted common priorities across different income countries and initiatives, but there was no agreement on the use of private funding for surveillance.
Genome-wide study of gene-by-sex interactions identifies risks for cleft palate.
Hum Genet
November 2024
Department of Human Genetics, Emory University, Atlanta, GA, 30322, USA.
Structural birth defects affect 3-4% of all live births and, depending on the type, tend to manifest in a sex-biased manner. Orofacial clefts (OFCs) are the most common craniofacial structural birth defects and are often divided into cleft lip with or without cleft palate (CL/P) and cleft palate only (CP). Previous studies have found sex-specific risks for CL/P, but these risks have yet to be evaluated in CP.
View Article and Find Full Text PDFAudit of oral neoplasms in children and young adults in Nigeria.
BMC Oral Health
October 2024
Department of Oral Pathology, Faculty of Dentistry, University of Ibadan, Ibadan, Nigeria.
Background: Orofacial neoplasms in children and young adults may differ significantly from those observed in adults. Our aim was to describe the epidemiological characteristics of histologically diagnosed orofacial neoplasms among children and young adults in Nigeria.
Methods: This was a multicenter cross-sectional study across geopolitical zones in Nigeria.
Prediabetes Associates with Matrix Metalloproteinase-8 Activation and Contributes to the Rapid Destruction of Periodontal Tissues.
Eur J Dent
October 2024
Department of Oral and Maxillofacial Diseases, Head and Neck Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Objective: The aim of this cross-sectional study was to investigate the relationship between periodontitis, potential periodontitis oral fluid biomarkers, and prediabetes.
Materials And Methods: This study included 150 Greek adults aged 25 to 78 years who were tested with an Hemoglobin A1C (HBA1c) diagnostic system, an active-matrix metalloproteinase-8 (aMMP-8) point-of-care (PoC) test, and several salivary biomarkers enzyme-linked immunosorbent assay tests and gelatin zymography. A full-mouth clinical examination was performed to assess their periodontal and oral health status.