1 results match your criteria: "University of KwaZulu-Natal College of Agriculture Engineering and Science[Affiliation]"
Novel Quinoline Schiff-Bases as Mtb DNA Gyrase Inhibitors - A Combined In Vitro and In Silico Study.
Chem Biodivers
January 2025
University of KwaZulu-Natal College of Agriculture Engineering and Science, Department of Chemistry, Westville Campus, Durban, SOUTH AFRICA.
A new series of quinoline Schiff-bases was designed, synthesized, and characterized using 1H NMR, 13C NMR, and HRMS analysis. Further, all the compounds were screened for their antitubercular, antibacterial, and antifungal activity, and the minimum inhibitory concentrations (MICs) were determined. Among all, compound 7f displayed a significantly potent broad-spectrum antitubercular and antimicrobial activity against most of the tested strains of bacteria and fungi, with MIC values in the range of 1.
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