Bioaccumulation of lead, arsenic, and mercury in vital organs of common carp ( L.): Assessment of pathological effects and possible hazards associated with human consumption.

Background: Pollution of aquatic environments with heavy metals causes severe adverse effects on fish, invertebrates, and human. The importance of this study lies in the fact that long-term ingestion of heavy metal-contaminated fish can result in the accumulation of harmful metals in numerous organs and pose a major risk to human health.

Aim: The current study was designed to investigate the concentrations of toxic arsenic (As), lead (Pb), and mercury (Hg) in the liver, gills, and muscles of highly consumed aqua cultured common carp ( L.

ABCC8 polymorphisms rs757110 and rs1801261 association with sulfonylurea therapy of Iraqi type 2 diabetics.

Objective: Aim: Our study aimed to investigate the connection between the ABCC8 gene polymorphisms (rs1801261 and rs757110) and T2DM in the Iraqi Middle Euphrates region. Patients with type 2 diabetes were chosen because they were treated with glibenclamide and glimepiride.

Patients And Methods: Materials and Methods: The groups of this case-control study are the control group obviously healthy persons included 400 (235 Male/165 Female) and 400 T2DM group (213 Male/ 187 Female).

Activity Assessment of Antibiotics Used Against Different Bacterial Etiological Agents of UTI in Najaf, Iraq.

Background & Objective: Antibiotic resistance in urinary tract infection (UTI) is increasing nowadays, therefore, the aim of this study was to evaluate the resistance patterns of many pathogens toward several antibiotics that are in common use in our hospitals.

Methods: Subculture and identification of pathogenic bacteria were performed on 1148 hospitals' bacterial primary cultures which were considered positive for UTI. An antibiotic sensitivity test was performed by using the disc diffusion method.

Transient numerical simulation to investigate pressure fluctuation spectrum and deficit in the near wake of a horizontal axis wind turbine.

Wind energy becomes one of the promised solutions as alternatives of using fossil power energy in the upcoming decades. As pressure fluctuation and flow deficit in the near wake play a crucial role in predicting the turbine performance, the novelty in the current study focuses on a three dimensional (3 D) transient numerical simulation to investigate near wake characteristics of NREL phase IV wind turbine. Pressure fluctuation spectrum and wake deficit at four sections downstream the turbine are the main parameters studied as well as the flow streams and iso-surface characteristics.

In Silico Study of New Isatin- Sulfonamide Derivatives as Carbonic Anhydrase Inhibitors.

Objective: Aim: To evaluate compound I, II, III, and IV's anticancer properties that have just been produced. These substances were created with the specific purpose of targeting solid tumors' carbonic anhydrase enzyme.

Patients And Methods: Materials and Methods: The chemical synthesis involved the use of 4-aminobenzenesulfonamide, Ethyl 4-aminobenzoate, isatin and its derivatives, absolute ethanol, DMF, glacial acetic acid.

Effect of Some Immunological Markers on The Level of Anti- Mullerian Hormone (AMH) in Women Infected with Toxoplasma gondii.

Objective: Aim: To study effect of T. gondii infection on levels of immunological parameters for possible effects that may appear in infected women in the future, and to study direct correlation of infection in raising AMH value.

Patients And Methods: Materials and Methods: 80 blood samples were collected and divided into two equal groups.

Cardioprotective strategies in the management of chemotherapy-induced cardiotoxicity: current approaches and future directions.

Background: Chemotherapy-induced cardiotoxicity (CIC) is a significant challenge in cancer treatment, leading to heart failure and myocardial infarction. With rising cancer survival rates, the long-term cardiovascular health of survivors has gained importance. While several cardioprotective medications have been studied to mitigate chemotherapy's harmful effects on the heart, more research is needed to confirm their effectiveness and optimal use.

Dandy-Walker syndrome: a bibliometric analysis of the most 100 cited articles.

Introduction: Dandy-Walker syndrome (DWS), a complex neurodevelopmental disorder, has intrigued clinicians and researchers since its description by physicians Walter Dandy and Arthur Walker. Despite its recognition for nearly a century, understanding its etiology, pathogenesis, and clinical manifestations remains elusive. This bibliometric analysis aims to elucidate influential academic works on DWS.

Design and synthesis of PDSPTCF as an influential Brønsted-Lewis acidic catalyst for the producing benzo[a]benzo[6,7]chromeno[2,3-c]phenazines.

Initially, 4,4'-(1,4-phenylene)di(sulfonic)pyridinium tetrachloroferrate (PDSPTCF) as a novel organic-inorganic hybrid salt was synthesized and identified by elemental mapping, energy-dispersive X-ray spectroscopy, inductively coupled plasma atomic emission spectrometer, Raman spectroscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, vibrating-sample magnetometry, and thermal gravimetric (TG) techniques. Then, the catalytic performance of this hybrid salt was assessed for the producing benzo[a]benzo[6,7]chromeno[2,3-c]phenazine derivatives via one-pot multicomponent domino reaction (MDR) of benzene-1,2-diamine, 2-hydroxynaphthalene-1,4-dione and aldehydes under optimal conditions (70 °C, solvent-free, 5 mol% PDSPTCF) in short reaction times and high yields. Highly efficacy of the PDSPTCF for the production of benzo[a]pyrano[2,3-c]phenazines can be assigned to the synergistic effect of Lewis and Brønsted acids, and having two positions of each acid (i.

Organ-specific renal tissue damage manifested by single-walled carbon-nanotubes and single-walled carbon-nanotubes-silver-titania nanocomposite: Cellular toxicity at high doses.

Background: Single-walled (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) can pose risks in biological systems leading to harmful effects, such as, reactive oxygen species (ROS) formation, DNA damage, mitochondrial dysfunction, and ultimately, the cell death through apoptosis.

Objectives: The study assessed the nephrotoxicity of the SWCNTs and SWCNTs-Ag-TiO nanocomposites through in vitro and in vivo experiments, assessing oxidative stress, genotoxicity, and safety for biomedical applications.

Methodology: In vitro, HK-2 cell lines were utilized to evaluate the effects of nanomaterials on cellular activity, apoptosis, ROS generation, and micronuclei formations.

Dual roles of extracellular vesicles in acute lymphoblastic leukemia: implications for disease progression and theranostic strategies.

Acute Lymphoblastic Leukemia (ALL) is a heterogeneous blood cancer characterized by the uncontrolled growth of immature lymphoid cells due to dysregulated signaling pathways. It is the most common pediatric cancer, with high cure rates in children, but significantly lower survival rates in adults. Current theranostic strategies, including chemotherapy, immunotherapy, and nanomedicine, aim to improve detection and treatment precision but are limited by side effects, drug resistance, high costs, and stability issues.

Applying clustered artificial neural networks to enhance contaminant diffusion prediction in geotechnical engineering.

This paper introduces a novel approach using Clustered Artificial Neural Networks (CLANN) to address the challenge of developing predictive models for multimodal dataset with extreme parameter values. The CLANN method strategically decomposes the dataset, derived from Finite Element Analysis (FEA), into clusters, each representing distinct diffusion behaviors, and applies specialized neural networks within these clusters. The CLANN model was rigorously evaluated and demonstrated superior accuracy and consistency compared to traditional methods such as the Adaptive Neuro-Fuzzy Inference System (ANFIS) and fuzzy expert systems.

Histopathological, immunohistochemical and physiological study for the hepatoprotective effect of melatonin against inhrifampicin-induced hepatotoxicity in mice model.

Objective: Aim: The purpose of this study is to assess the hepatoprotective ef f ect of melatonin against isoniazid (INH) and rifampicin (RMP) induced hepatotoxicity in albino mice.

Patients And Methods: Materials and Methods: Adult male mice were divided into four groups: saline, INH-RMP, INH-RMP+MT and MT were administered for 21 days. Biochemical analyses were performed for the determination of ALT, AST.

Foix-Alajouanine syndrome: a comprehensive overview of rare but relevant diagnosis.

Introduction: Foix-Alajouanine syndrome (FAS) is an uncommon neurological disorder marked by the gradual development of spinal cord congestion. First documented by Foix and Alajouanine in 1926. Although it is infrequent, delayed or misdiagnosis is nonetheless prevalent, resulting in inadequate therapy and unfavorable results.

Drug-coated balloons versus drug-eluting stents in patients with in-stent restenosis: An updated meta-analysis with trial sequential analysis.

Background: Drug-coated balloons (DCB) have promising results in the management of in-stent restenosis (ISR), still their role remains a major challenge, and not well established in contemporary clinical practice.

Aims: To provide a comprehensive appraisal of the efficacy and safety of DCBs in patients with in-stent restenosis (ISR).

Methods: We searched PubMed, Scopus, web of Science, Ovid, and Cochrane Central from inception until 30 March, 2023.

The Ventriculoperitoneal Shunt Complication Rate in Baghdad Medical City from 2019 to 2022.

Objective: Due to the substantial lack of data from Iraq on ventriculoperitoneal shunt (VPS) complications, this study aims to examine the various types of complications after VPS surgery in Baghdad Medical City.

Methods: The retrospective cohort study analyzed VPS procedures at Baghdad Medical City from 2019 to 2022. The overall complication rate, including infection and shunt malfunction, was determined from patient records.

Micronutrient interactions: Magnesium and its synergies in maternal-fetal health.

Magnesium is an essential nutrient for various physiological processes and becomes even more vital during pregnancy, contributing to muscle relaxation, bone development, electrolyte balance, and blood pressure regulation. Despite the fact that the dietary sources of magnesium are diversified, it is still challenging to obtain it in sufficient quantities during pregnancy. We have elucidated its interactions and its specific impact on maternal-fetal health in different research publications.

Efficient amide bond formation tropylium ion organocatalysis.

Amide bond formation is a fundamental reaction in organic synthesis, essential for the construction of peptides and various bioactive molecules. Traditional methods for amide bond formation often require harsh conditions, expensive reagents, or generate undesirable by-products. Herein, we report a novel and efficient method for amide bond formation utilizing tropylium ion organocatalysis.

Nephroprotective role of resveratrol in renal ischemia-reperfusion injury: a preclinical study in Sprague-Dawley rats.

Background: Renal ischemia-reperfusion injury (IRI) is a significant contributor to renal dysfunction, acute kidney injury (AKI), and associated morbidity and mortality. Resveratrol, a polyphenol and phytoalexin, is known for its anti-inflammatory, antioxidant, and anti-cancer properties. This study investigates the nephroprotective potential of resveratrol in a rat model of renal IRI.

Diabetic macular edema (DME): dissecting pathogenesis, prognostication, diagnostic modalities along with current and futuristic therapeutic insights.

One of the most common health concerns disturbing people within working years globally is diabetes mellitus (DM). One well-known consequence of DM is vascular damage, which can manifest as macro- and microangiopathy affecting the ocular retina. Therefore, Diabetic macular edema (DME) is a major sight-threatening complication of diabetic retinopathy (DR) worldwide.