Aged garlic extract preserves beta-cell functioning via modulation of nuclear factor kappa-B (NF-κB)/Toll-like receptor (TLR)-4 and sarco endoplasmic reticulum calcium ATPase (SERCA)/Ca in diabetes mellitus.

Background: Peripheral insulin resistance and compromised insulin secretion from pancreatic β-cells are significant factors and pathogenic hallmarks of diabetes mellitus (DM). NF-κβ/TLR-4 and SERCA/Ca pathways have been identified as potential pathways regulating insulin synthesis by preserving pancreatic β-cell functioning. The current study aimed to evaluate the therapeutic effect of aged garlic extract (AGE) against DM in a streptozotocin (STZ)-induced rat model with particular emphasis on pancreatic β-cell functioning.

Diet quality as a mediator in the relationship between perceived stress and depression among family caregivers of patients with chronic illness in Saudi Arabia.

Objective: The purpose of this research was to examine the correlation between caregivers' perceived stress and depression and the mediating role of diet in this relationship.

Methods: A cross-sectional survey was performed from January to August 2022 in the Kingdom of Saudi Arabia. Utilizing the Stress Scale, the Anxiety and Depression Scale, the Health Promoting Lifestyle Profile-II questionnaire, and the Patient Health Questionnaire-9, researchers assessed levels of perceived stress, diet quality, and depression.

Fungal Dysbiosis in Children with Celiac Disease.

Background: Although intestinal fungi are known to interact with the immune system, the relationship between intestinal fungi and childhood celiac disease (CeD), an immune-mediated condition, has rarely been reported.

Aims: The aim of this study was to describe gut fungal profiles in a cohort of children with new-onset CeD.

Methods: Mucosal and fecal samples were collected from children with CeD and controls and subjected to metagenomics analysis of fungal microbiota communities.

Biallelic mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation.

RIPK1 (receptor-interacting serine/threonine kinase 1) is a master regulator of signaling pathways leading to inflammation and cell death and is of medical interest as a drug target. We report four patients from three unrelated families with complete RIPK1 deficiency caused by rare homozygous mutations. The patients suffered from recurrent infections, early-onset inflammatory bowel disease, and progressive polyarthritis.

Clinical Pattern of Early-Onset Inflammatory Bowel Disease in Saudi Arabia: A Multicenter National Study.

Background: The objectives of this multicenter national study were to compare the clinical phenotype of early-onset inflammatory bowel disease (IBD) (EO-IBD) with IBD in older children and to examine whether there is any variability in consanguinity rate and familial aggregation in EO-IBD compared with later onset IBD.

Methods: A retrospective analysis was performed on children aged 0 to 14 years with IBD in 17 centers located in geographically distinct regions in Saudi Arabia, from 2003 to 2012. Data of patients with EO-IBD (0 to <6 yrs) were compared with those with later onset IBD (6-14 yrs).

How does esophagus look on barium esophagram in pediatric eosinophilic esophagitis?

Purpose: The clinical, endoscopic, and histologic findings of eosinophilic esophagitis (EoE) are well characterized; however, there have been very limited data regarding the radiologic findings of pediatric EoE. We report on the radiologic findings of pediatric EoE observed on barium esophagram and correlate them with the endoscopic findings.

Methods And Materials: We identified children diagnosed with EoE in our center from 2004 to 2015.

Gastric adenocarcinoma presenting with gastric outlet obstruction in a child.

Gastric carcinoma is extremely rare in children representing only 0.05% of all gastrointestinal malignancies. Here, we report the first pediatric case of gastric cancer presenting with gastric outlet obstruction.

Eosinophilic esophagitis in a developing country: is it different from developed countries?

Background and Objective. Despite the extensive reporting of eosinophilic esophagitis (EoE) from industrialized developed countries, reports from developing countries are rare. The aim of our study was to determine the epidemiological, clinical, and endoscopic features of EoE and response to therapy in children and adults from a developing country, Saudi Arabia.

Prevalence of hepatopathy in type 1 diabetic children.

Background: The Prevalence of liver disease among diabetics has been estimated to be between 17% and 100%. Most of these data were obtained from adult studies. The aim of our study was to screen for liver disease among type 1 diabetic children.

Oral home care and the reasons for seeking dental care by individuals on renal dialysis.

A cross-sectional study of 90 patients on renal dialysis was conducted to assess oral home care practices and the reasons for seeking dental care among these patients. Participants were divided into three groups based on the time they have been on renal dialysis. The groups were: (1) dialysis for less than one year, (2) dialysis for 1 to 3 years, and (3) dialysis for more than 3 years.

Antimicrobial activity of extracts of calcium hydroxide points.

The purpose of this study was to evaluate in vitro the antibacterial effect of calcium hydroxide points by using a broth dilution test. Extracts of calcium hydroxide points and a calcium hydroxide paste (Calasept) were tested by using 2 facultative anaerobic bacteria, Streptococcus mutans (ATCC 27352) and Enterococcus faecalis (ATCC 29212). Saline solution was used as a control.

Eggshell conductance, embryonic growth, hatchability and embryonic mortality of broiler breeder eggs dipped into ascorbic acid solution.

1. Eggs from a broiler breeder flock between 25 and 29 weeks of age were dipped into solutions of various concentrations of ascorbic acid (AA) for up to 2 min, in order to evaluate its effects on eggshell conductance (EC), amniotic fluid pH, albumen height and pH, embryonic weight and hatchability. 2.

Light and SEM observation of internal root resorption of a traumatized permanent central incisor.

A clinical case report is presented which illustrates internal root resorption of a traumatized tooth. Light and scanning electron microscope were used to further examine the defect. An explanation of the morphological structure of the resorption is discussed.

External root resorption after bleaching: a case report.

An external root resorption occurred after bleaching and was diagnosed radiographically in a 26-year-old female dental assistant. The resorption was noticed 6 months after bleaching. The involved tooth had no history of trauma.

Two root canals in a maxillary central incisor with enamel hypoplasia.

Presented is a case of enamel hypoplasia of a maxillary central incisor which was referred for endodontic therapy. Radiographical examination revealed a tooth having one root and two canals. Endodontic therapy was performed under aseptic conditions.

Morphological cell changes due to chemical toxicity of a dental material: an electron microscopic study on human periodontal ligament fibroblasts and L929 cells.

New endodontic materials with polymer bases may be more difficult to evaluate in cell cultures in vitro than conventional zinc oxide-eugenol cements. In order to study the morphological changes taking place in cells exposed to such materials, L929 cells and human periodontal fibroblasts were observed using scanning electron microscopic and transmission electron microscopic techniques. The morphological changes of the cells were correlated to the quantitative results observed simultaneously in cytotoxicity studies using the radiochromium release method.