Gesture centric interaction: evaluating hand and head gestures in touchless cursor control.

Touchless interfaces have gained considerable importance in the modern era, particularly due to their user-friendly and hygienic nature of interaction. This article presents the designing of two touchless cursor control systems based on hand gestures and head movements utilising the MediaPipe framework to extract the key landmarks of the hand and face utilising a laptop camera. The index finger's landmark points are tracked and converted to corresponding screen coordinates for cursor control.

chondrogenic potential of marine biocomposite hydrogel construct for cartilage tissue engineering.

Cartilage tissue engineering (CTE) is a field of regenerative medicine focused on constructing ideal substitutes for injured cartilage by effectively combining cells, scaffolds, and stimulatory factors. CTE employing chondrocytes and biopolymer-based hydrogels has the potential to repair damaged cartilage. In this research, primary chondrocytes were extracted from the rib cartilage of rats and seeded on a hydrogel construct named HACF, which is made from hydroxyapatite, alginate, chitosan, and fucoidan.

An assessment of in vitro lead (Pb) bioaccumulation of Dianthus chinensis L. (Chinese pink).

Heavy metals (HM) also known as potentially toxic elements (PTEs), are well-known environmental pollutants, among which lead (Pb) is a widespread and hazardous soil contaminant. Its removal from soil sediments is often difficult to achieve. In this study, in vitro experiments were conducted to investigate the bioaccumulation capability of Dianthus chinensis L.

Exploring health worker absenteeism at public healthcare facilities in Chhattisgarh, India.

Aim: This study aims to assess the health worker absenteeism and factors associated with it in a high-focus district in Chhattisgarh, India.

Background: Human resources for health are among the key foundations to build resilient healthcare systems. Chhattisgarh is a high-focus Indian state with a severe shortage of health care workers, and absenteeism further aggravates the shortage.

Seagrass Meadows: Prospective Candidates for Bioactive Molecules.

Seagrass meadows consist of angiosperms that thrive fully submerged in marine environments and form distinct ecosystems. They provide essential support for many organisms, acting as nursery grounds for species of economic importance. Beyond their ecological roles, seagrasses and their associated microbiomes are rich sources of bioactive compounds with the potential to address numerous human healthcare challenges.

A deep drug prediction framework for viral infectious diseases using an optimizer-based ensemble of convolutional neural network: COVID-19 as a case study.

The SARS-CoV-2 outbreak highlights the persistent vulnerability of humanity to epidemics and emerging microbial threats, emphasizing the lack of time to develop disease-specific treatments. Therefore, it appears beneficial to utilize existing resources and therapies. Computational drug repositioning is an effective strategy that redirects authorized drugs to new therapeutic purposes.

Impregnation of two-dimensional manganese dioxide nanosheets with 5-carboxyfluorescein as an immunoassay platform for sensitive detection of cardiac troponin T.

A novel immunoassay platform is presented utilizing a cardiac troponin T antibody (Ab-cTnT) labelled with 5-carboxyfluorescein (5-FAM) integrated into a two-dimensional (2D) manganese dioxide nanosheet (MnO NS) matrix. This strategy enables a turn-on response towards cTnT antigen within a mere 10-min incubation period, boasting an impressive lower detection limit of 0.038 ng/mL.

Synthesis, Characterization and Assessment of Antioxidant and Melanogenic Inhibitory Properties of Edaravone Derivatives.

A series of edaravone derivatives and the corresponding Cu(II) complexes were synthesized and characterized using spectroscopic and analytical techniques such as IR, UV, NMR and elemental analysis. Antioxidant activities of all compounds were examined using free radical scavenging methods such as hydrogen peroxide scavenging activity (HPSA), 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2-2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) (ABTS) assays. All of the tested compounds exhibited good antioxidant activity.

High loading and sustained-release system of doxorubicin-carbon dots as nanocarriers for cancer therapeutics.

Nanocarriers for drugs have been investigated for decades, yet it is still challenging to achieve sustained release from nanomaterials due to drug loading inefficiency and burst release. In this study, we developed novel functional carbon dots (CDs) and investigated the therapeutic efficacy by studying the loading efficiency and release behavior of the anticancer drug doxorubicin (DOX). CDs were successfully synthesized using a one-step pyrolysis method with varying concentrations of citric acid (CA) and thiourea (TU).

Effects of L-NAME and air exposure on mitochondrial energetic markers, thyroid hormone receptor/regulator system and stress/ease-responsive receptor expression in the brain/gut axis of zebrafish.

As a signal molecule, nitric oxide (NO) has several physiological actions in fish. However, the action of NO on the brain/gut axis, a classic inter-organal axis that bridges the gastrointestinal tract and the CNS, still requires more understanding. The short-term in vivo action of a NO inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME), on mitochondrial energetic markers and the receptor expression of thyroid hormone (TH) and neuroendocrine hormones involved in stress/ease response was tested in the brain/gut axis of zebrafish exposed to either in non-stressed or air-exposed condition.

Changes of ecological vulnerability in areas with different urban expansion patterns- A case study in the Yanhe river basin, China.

Urban expansion has the potentiality to disrupt ecosystems and form highly fragile urban landscapes. However, studies investigating the impact of different urban expansion patterns on the ecological environments are relatively limited. Taking the Yanhe river basin, a typical basin in a loess region, as a case study, we developed an ecological vulnerability assessment system as well as assessed the main drivers of ecological vulnerability for different time periods (1990, 2000, 2010 and 2018).

Environmental drivers of mesozooplankton dynamics in the Munroe Island, adjacent to Ashtamudi Estuary, India.

The response of mesozooplankton is critical in assessing the health of an estuarine ecosystem. Reports on the spatial and temporal dynamics of mesozooplankton community in estuarine and backwaters of the Southern parts of India are scanty. In this scenario, we appraised the community structure of mesozooplankton and their spatio-temporal dynamics based on various multivariate statistical assessments.

Brown algae biomass for fucoxanthin, fucoidan and alginate; update review on structure, biosynthesis, biological activities and extraction valorisation.

Natural compounds promoting human health are the main focus of research nowadays. Fucoxanthin, fucoidan and alginate are such bioactive compounds that are extracted from marine brown algae. Extracting these 3 compounds through successive extraction enhances the commercial value of the brown algae biomass.

Step-by-Step Tuning of Tribological and Anticorrosion Performance of Zinc Phosphate Conversion Coatings through Effective Integration of Spherical P-Doped MoS Nanoparticles.

Surface coatings with enhanced mechanical stability, improved tribological performance, and superior anticorrosion performance find immense application in various industrial sectors. Herein, we report the development of multifunctional composite zinc phosphate coatings by the effective integration of a structurally and morphologically tuned P-doped MoS nanoparticle additive (3P-MoS) into the zinc phosphate matrix to offer attractive characteristics suitable for industrial applications. The integration of spherical nanoparticles as additive leads to the formation of homogeneous and compact coatings with a densely packed crystalline microstructure having enhanced microhardness, distinctive leaf-like morphology, and comparatively smooth topographical features.

Inhibition of Monkeypox Virus DNA Polymerase Using Phytochemicals: Computational Studies of Drug-Likeness, Molecular Docking, Molecular Dynamics Simulation and Density Functional Theory.

The emergence of zoonotic monkeypox (MPX) disease, caused by the double-stranded DNA monkeypox virus (MPXV), has become a global threat. Due to unavailability of a specific small molecule drug for MPX, this study investigated phytochemicals to find potent and safe inhibitors of DNA Polymerase (DNA Pol), a poxvirus drug target due to its role in the viral life cycle. For that, 146 phytochemicals were screened through drug-likeness and molecular docking analyses.

Solvent effect, DFT and NLO studies of A-π-D-π-A and A-π-D-π-D push-pull chromophore of 1,2-diazepin-4-ol based derivatives with optical limiting application.

The nonlinear optical properties of push-pull chromophores, namely (E)-7-(4-bromophenyl)-2,5-bis(4-nitrophenyl)-3,4,5,6-tetrahydro-2H-1,2-diazepin-4-ol (A-π-D-π-A) and (E)-7-(4-bromophenyl)-5-(4-nitrophenyl)-2-phenyl-3,4,5,6-tetrahydro-2H-1,2-diazepin-4-ol (A-π-D-π-D), have been investigated using the z-scan technique. NMR, FT-IR, and UV-visible spectral analysis have been performed. The results were compared with density functional theory calculations employing the B3LYP/6-311++G (d, p) basis set.