Sesamol protects against LPS-induced inflammation in rat peritoneal macrophages by promoting SIRT1-induced repression of NF-κB.

Objectives: Sesamol, a polyphenolic compound isolated from roasted sesame seeds exhibits significant anti-inflammatory effect, but the molecular mechanism is poorly understood. Peritoneal macrophages play a pivotal role in the control of infections and inflammatory pathologies and are also found in injured tissues along with resident macrophages. The present study aimed to examine the anti-inflammatory effect of sesamol and the molecular mechanisms involved, particularly the role of sesamol in modulating SIRT1- and SIRT1-mediated deacetylation of NF-κB p65 using in vivo activated peritoneal macrophages.

Transcriptomic analysis reveals pathogenicity mechanisms of in black pepper.

The devastating disease "quick wilt" or "foot rot" is caused by the oomycete Leonian and is affecting the economically significant spice crop black pepper ( L.). The details on the mechanism of interaction of with its host black pepper remain poorly understood, hindering efforts to enhance disease resistance.

Triggering the Interplay of sp-sp Carbon-Assisted Sustained Tribofilm via Two-Dimensional Surface Modulation for Exceptional Wear Resistance of Steel Surfaces.

The relentless wear and friction of steel-based moving machinery have created ongoing challenges that hinder their industrial applications. One promising solution is the use of reduced graphene oxide (rGO) as a lubricant due to its excellent mechanical strength and promising tribological properties. However, its tendency to self-agglomerate presents a major hurdle for its practical use.

TFA-promoted (hetero)arylation/hydroxylation of quinoxaline-2-one derivatives with electron-rich aromatic compounds.

A metal- and solvent-free, one-pot and TFA-promoted method for the construction of hetero/aryl-substituted quinoxalin-2-ones, pyrazin-2(1)-ones, and pyrimidin-4(3)-ones is reported. This method involves the reaction of chloro-derivatives of nitrogen heterocycles with electron-rich arenes/heteroarenes, followed by hydroxylation. This protocol is easy to use, providing access to (hetero)aryl-substituted -heterocycles in good yields.

Decoding early-onset of colorectal cancer: Insights into SERPINA3 expression patterns.

Early-onset colorectal cancer (EOCRC), recognized as a distinct subgroup with an increased incidence over the past two decades, characterized by its aggressive nature and potentially unique molecular factors that differentiate it from traditional colorectal cancer (CRC). In this study, we investigated differentially expressed genes in a young-CRC patient using paired-end mRNA-sequencing. Validation of target genes through qRT-PCR highlighted a significant increase in SERPINA3 levels in EOCRC, representing a novel finding.

Self-assembled sustainable bionanocomposite hydrogels from chitosan for the combination chemotherapy of hydrophobic and hydrophilic drugs.

Self-assembled hydrogels derived from naturally sourced polymers have gained significant interest in drug delivery applications, owing to their potential, exceptional biocompatibility and sustainable properties. This work presents the development and application of self-assembled nanocomposite hydrogels from chitosan and nanosilver as a pH responsive drug delivery system for the controlled release of doxorubicin and paclitaxel in anticancer therapy. Chitosan was functionalized with 4-formyl benzoic acid for incorporating both hydrophobic and hydrophilic anticancer drugs.

Integrative Investigation of Flavonoids Targeting YBX1 Protein-Protein Interaction Network in Breast Cancer: From Computational Analysis to Experimental Validation.

Y-box-binding protein 1 (YBX1) is a multifunctional oncoprotein with its nuclear localization contributing to chemo-resistance in breast cancer. Through its interactions with various proteins and lncRNAs, YBX1 promotes cancer cell migration, invasion, and metastasis. Despite its significant role in cancer progression, studies on YBX1's protein-protein interactions (PPIs) remain limited.

Complex network-based multistep forecasting model for hyperchaotic time series.

We present a method for predicting hyperchaotic time series using a complex network-based forecasting model. We first construct a network from a given time series, which serves as a coarse-grained representation of the underlying attractor. This network facilitates multistep forecasting by capturing the local nonlinearity of the dynamics and offers superior accuracy over more extended periods than traditional methods.

Esterase-responsive nanoparticles (ERN): A targeted approach for drug/gene delivery exploits.

Nanoparticles are being developed to enhance drug delivery to cancer tumors, leveraging advantages such as the enhanced permeability and retention (EPR) effect. However, traditional nanoparticles often face challenges with low specificity for cancer cells, leading to inefficient delivery and unwanted side effects. Esterase-responsive nanoparticles offer a maximum targeted approach to tumor cells because they release their therapeutic payload at the tumor site under the influence of esterase activity.

Sustained energy generation from unusable waste steel through microbial assisted fuel cell systems.

In the present study, a novel green energy generation process assisted with Microbial Fuel Cell (MFC) principle for generation of electricity from used or wasted steel is explored. Through a unique approach, unused and other steel waste are recast by simple re-melting with a flexible wide composition for generation of green energy. A microbial-assisted electron transfer derived from the degradation of the steel material is utilized for production of green energy in a microbial galvanic reactor system.

Spatial distribution studies on sedimentary organic matter along the shoreline of Arabian Sea: insights from Kollam, Southwest Coast, India.

The present study was aimed at investigating the source, quality, and quantity of organic matter and labile fraction of biochemical constituents in the surficial sediments of Arabian Sea Shoreline at Kollam, India, which gives an input into the processes associated with the subsurface geochemistry pattern. About 15 surface sediment samples were collected from the five beaches for this study during January 2021. The samples were analyzed for CHN, total organic carbon (TOC), and labile fraction such as carbohydrates (CHO), proteins (PRO), and lipids (LIP).

Thyroid hormones activate TH/E receptor/regulator system and drive Na/K-ATPase in the ovarian wall of hypothyroid air-breathing fish (Anabas testudineus Bloch).

In fish, as in other vertebrates, thyroid hormones (THs) act on many biological processes including growth and reproduction. Primary THs such as thyroxine (T) and triiodothyronine (T) are known for their direct action on osmoregulatory organs regulating ion osmotic homeostasis in many teleost fishes. However, it is unclear how these hormones interact with estradiol-17β (E), an ovarian hormone that regulates the development of oocytes.

Beyond the triple bond: unlocking dinitrogen activation with tailored superbase phosphines.

Activating atmospheric dinitrogen (N), a molecule with a remarkably strong triple bond, remains a major challenge in chemistry. This theoretical study explores the potential of superbase phosphines, specifically those decorated with imidazolin-2-imine ((ImN)P) and imidazolin-2-methylidene ((ImCH)P) to facilitate N activation and subsequent hydrazine (HNNH) formation. Using density functional theory (DFT) at the M06L/6-311++G(d,p) level, we investigated the interactions between these phosphines and N.

Bioenergy products sequestration proportions among three mixotrophically cultivated microalgae by remediating two organic waste resources.

In this study, three microalgae species were cultivated using dairy and fish wastewater: , and sp. The process involved manipulating various physicochemical conditions, to determine optimal growth parameters. Our evaluation considered cell count, biomass productivity, specific growth rate, pigments, carbohydrates, proteins, lipid compositions, and cellulose stored in microalgae.

Computational screening of phytocompounds from identifies potential inhibitors of influenza A (H3N2) virus by targeting hemagglutinin.

The H3N2 subtype of the influenza A virus continues to be a notable public health issue due to its association with seasonal epidemics and severe human morbidity. The constrained effectiveness of current antiviral medications, combined with the inevitable emergence of drug-resistant variants, mandates the exploration of innovative therapeutic approaches. This study focuses on the identification of phytocompounds from with the potential to target hemagglutinin, viral protein involved in viral entry by binding to sialyl glycoconjugates receptors on the surface of host cells.

Rapid synthesis of cobalt manganese phosphate by microwave-assisted hydrothermal method and application as positrode material in supercapatteries.

Electrochemical energy storage devices with high specific capacity are of utmost important for the next-generation electronic devices. Supercapatteries (SCs) are highly demanded energy storage devices nowadays as these bridge the low energy supercapacitors and low power batteries. Herein, we report a rapid synthesis of cobalt manganese phosphate (COMAP) by microwave-assisted hydrothermal method and facile fabrication of SCs using electrodes comprising of COMAP as positrode material.

Exploring the potential of diosgenin as a promising antitumor agent through comprehensive spectroscopic characterization, solvent-solute interactions, topological properties, Hirshfeld surface, and molecular docking interactions with 2NZT and 2I1V proteins.

This study characterizes the steroidal saponin diosgenin by theoretical and experimental spectroscopic techniques. Theoretical simulations were performed using the DFT/B3LYP/6-311++G(d,p) basis set to simulate spectroscopic, structural and other properties. Optimized geometries from simulations and experiments showed strong agreement, with R value of 0.

Immunosensing of Cardiac Troponin I (cTnI) Using a Two-Electrode Electrochemiluminescence Platform with Near Persisting Luminescence Generated on a Ru(bpy)-Tripropylamine System.

An economical, rapid, and ultrasensitive detection of biomolecules in clinical settings is very crucial, particularly for the early detection of Cardiac Troponin I (cTnI), which is the gold standard biomarker for Acute Myocardial Infarction (AMI). Electrochemiluminescence (ECL) has risen in prominence as an important technique for in vitro diagnosis and detection by virtue of its high sensitivity reaching a femtomolar level. This study introduces an economically feasible nanoplatform for ECL immunosensing, consisting of a gold nanoparticle (AuNP) with Ru(bpy) and tripropylamine (TPA) system, which is a potential ECL luminophore and coreactant system.

Exploring Selective Fluorescence Turn-On Sensing of Caspase-3 with Molybdenum Disulfide Quenched Copper Nanoclusters: FRET Biosensor.

Sensing caspase-3 activity is essential for understanding the role of apoptosis in cancer dynamics, controlling therapeutic strategies, and improving patient care in cancer treatment. In this study, we demonstrate a highly sensitive recombinant human caspase-3 (rhC3) detection technique in biological fluids. This technique uses a copper nanocluster stabilized with bovine serum albumin (BSA-CuNCs) as a metal-based fluorescent biosensor, conjugated with anti-human caspase-3 (ahC3).

Anaemia among lactating adolescents (15-19 years) in India: a repeated cross-sectional analysis of the NFHS data (2005-2021).

Background: Anaemia continues to be a pressing public health concern in India. Despite the high burden of anaemia among lactating adolescents in the country, research addressing this concern among this population remains scarce. Hence, this study attempted to examine the prevalence and determinants of anaemia among lactating adolescents in India.