Lead-Free Piezoelectric Energy Harvester Based on 2D Bismuth Titanate.

The use of two-dimensional (2D) layered materials with a noncentrosymmetric structure dramatically increases the potential of nanoscale electromechanical systems and electronic devices. In this work, liquid-phase exfoliation of bulk bismuth titanate was employed to synthesize atomically thin 2D sheets and fabricate a high-performance piezoelectric energy harvester. The structural and morphological properties of the 2D sheets were analyzed, confirming their phase purity and layer formation.

β-Cyclodextrin-Stabilized CuO/MXene Nanocomposite as an Electrode Material for High-Performance Supercapacitors.

Supercapacitors are the best energy storage systems due to their high power density, quick charge/discharge rate, and long-term reliability. In this study, β-cyclodextrin-stabilized CuO nanoparticles (CuO@βCD NPs) were synthesized through a simple reduction method and anchored on the surface of MXene nanosheets in three different proportions (1:1, 4:1, and 1:4) to obtain CuO@βCD/MXene nanocomposites through the wet-impregnation method. The formation of CuO@βCD NPs and their physicochemical characteristics were verified by XRD, XPS, FE-SEM, and HR-TEM analysis.

Effects of gut microbiome and obesity on the development, progression and prevention of cancer (Review).

Cancer is one of the leading causes of death worldwide and it is estimated that the mortality rate of cancer will increase in the coming years. The etiology of the development and progression of cancer is multifactorial. Insights have been gained on the association between the human microbiome and tumor cell malignancy.

Molecular cloning, overexpression, characterization, and In silico modelling analysis of a novel GDSL autotransporter-dependent outer membrane lipase (OML) of Pseudomonas guariconensis.

The outer membrane lipase (oml) gene, encoding a novel autotransporter-dependent lipase from Pseudomonas guariconensis, was cloned and sequenced. The oml gene has an open reading frame of 1866 bp. It encodes the 621 amino acid autotransporter-dependent GDSL lipase (OML), which has the highest sequence similarity (64.

Myrtenal exhibits cardioprotective effects by attenuating the pathological progression associated with myocardial infarction.

Background: Myocardial infarction poses major risks to human health because of their incredibly high rates of morbidity and mortality. Infarctions are more likely to develop as a result of dysregulation of cell death. Myrtenal can be considered for their bioactive beneficial activity in the context of cardiovascular pathologies and, particularly, in the protection toward oxidative stress followed by ischemic injury.

Protection by Nano-Encapsulated Bacoside A and Bacopaside I in Seizure Alleviation and Improvement in Sleep- In Vitro and In Vivo Evidences.

Therapeutic options to contain seizures, a transitional stage of many neuropathologies, are limited due to the blood-brain barrier (BBB). Herbal nanoparticle formulations can be employed to enhance seizure prognosis. Bacoside A (BM3) and bacopaside I (BM4) were isolated from Bacopa monnieri and synthesized as nanoparticles (BM3NP and BM4NP, respectively) for an effective delivery system to alleviate seizures and associated conditions.

Amomum subulatum fruits protect against radiation-induced esophagitis by regulating antioxidant status and inflammatory responses.

Radiation esophagitis (RE) is an inimical event that requires proper management while carrying out radiotherapy for thoracic cancers. The present study investigates the protective effect of dry fruits of the culinary and folkloric spice Amomum subulatum against experimental thoracic radiation-induced esophagitis. C57BL/6 mice were subjected to 25 Gy whole thorax irradiation and administered with 250 mg/kg body weight of methanolic extract of A.

Ensembled CNN with artificial bee colony optimization method for esophageal cancer stage classification using SVM classifier.

Background: Esophageal cancer (EC) is aggressive cancer with a high fatality rate and a rapid rise of the incidence globally. However, early diagnosis of EC remains a challenging task for clinicians.

Objective: To help address and overcome this challenge, this study aims to develop and test a new computer-aided diagnosis (CAD) network that combines several machine learning models and optimization methods to detect EC and classify cancer stages.

Transcriptome Profiling of Cardiac Glycoside Treatment Reveals EGR1 and Downstream Proteins of MAPK/ERK Signaling Pathway in Human Breast Cancer Cells.

Cardiac glycosides (CGs) constitute a group of steroid-like compounds renowned for their effectiveness in treating cardiovascular ailments. In recent times, there has been growing recognition of their potential use as drug leads in cancer treatment. In our prior research, we identified three highly promising CG compounds, namely lanatoside C (LC), peruvoside (PS), and strophanthidin (STR), which exhibited significant antitumor effects in lung, liver, and breast cancer cell lines.

Unraveling pnicogen bonding cooperativity: Insights from molecular electrostatic potential analysis.

A theoretical investigation on the cooperativity of a series of binary, ternary, and quaternary complexes interconnected by pnicogen bonds has been conducted using calculations at the M06-2X/aug-cc-pVTZ level of density functional theory. By measuring changes in the molecular electrostatic potential (MESP) at the nucleus of interacting atoms in all of the complexes, it is possible to quantify the substantial reorganization of the electron density triggered by the formation of pnicogen bonds. The positive change in MESP, indicating a loss of electron density from the donor molecule in a dimer, facilitates the acceptance of electron density from a third molecule, resulting in the formation of a ternary complex with a stronger pnicogen bond compared to the one present in the binary complex.

Sustainable application of electrocatalytic and photo-electrocatalytic oxidation systems for water and wastewater treatment: a review.

Wastewater treatment and reuse have risen as a solution to the water crisis plaguing the world. Global warming-induced climate change, population explosion and fast depletion of groundwater resources are going to exacerbate the present global water problems for the forthcoming future. In this scenario, advanced electrochemical oxidation process (EAOP) utilising electrocatalytic (EC) and photoelectrocatalytic (PEC) technologies have caught hold of the interest of the scientific community.

Effect of titanium dioxide nanocoating on the colour stability of room temperature vulcanizing maxillofacial silicone-an invitro study.

Objective: The aim of this in vitro study was to evaluate the effect of an oxide nanocoating to prevent colour degradation of maxillofacial silicone elastomers following accelerated ageing.

Material And Methods: Specimens (N = 40) of specified dimensions were fabricated in Factor II room temperature vulcanizing (RTV) silicone and processed according to the manufacturer's instructions. Two groups were classified with 20 specimens each.

Use of near infrared spectroscopy for the prediction of perioperative complications in patients undergoing elective microsurgical resection of cerebral arteriovenous malformations- a prospective observational trial (NIRSCAM trial).

Purpose: Cerebral arteriovenous malformations (AVM) represent focal abnormal areas of low resistance circulation which render the peri-nidal neuronal tissue susceptible to ischemia. The post-excision cerebral perfusion surge can result in hyperaemic complications.We hypothesised that Near Infrared Spectroscopy (NIRS)-guided perioperative management can aid in the prediction and prevention of perioperative complications in patients presenting for surgical excision of cerebral AVMs.

Epidemiology of scrub typhus and other rickettsial infections (2018-22) in the hyper-endemic setting of Mizoram, North-East India.

Background: In the past decade, scrub typhus cases have been reported across India, even in regions that had no previous history of the disease. In the North-East Indian state of Mizoram, scrub typhus cases were first recorded only in 2012. However, in the last five years, the state has seen a substantial increase in the scrub typhus and other rickettsial infections.

PEGylation of a shell over core-shell MOFs-a novel strategy for preventing agglomeration and synergism in terms of physicochemical and biological properties.

We demonstrate a new strategy of PEGylation over core-shell MOFs of HKUST-1 and Cu-MOF-2 by a solvothermal method. The novel synthesized PEGylated core-shell MOFs has synergistic enhancement in terms of physicochemical and biological properties. FTIR spectroscopy and XRD analysis described the bonding characteristics of the double-shelled-core MOFs PEG@HKUST-1@CuMOF-2 and PEG@CuMOF-2@HKUST-1.

Transcriptome analysis of Corvus splendens reveals a repertoire of antimicrobial peptides.

Multidrug resistance has become a global health problem associated with high morbidity and mortality. Antimicrobial peptides have been acknowledged as potential leads for prospective anti-infectives. Owing to their scavenging lifestyle, Corvus splendens is thought to have developed robust immunity to pathogens found in their diet, implying that they have evolved mechanisms to resist infection.

Feasibility of bioplastic production using micro- and macroalgae- A review.

Plastic disposal and their degraded products in the environment are global concern due to its adverse effects and persistence in nature. To overcome plastic pollution and its impacts on environment, a sustainable bioplastic production using renewable feedstock's, such as algae, are envisioned. In this review, the production of polymer precursors such as polylactic acid, polyhydroxybutyrates, polyhydroxyalkanoates, agar, carrageenan and alginate from microalgae and macroalgae through direct conversion and fermentation routes are summarized and discussed.

AS1411 aptamer tagged PEGylated liposomes as a smart nanocarrier for tumor-specific delivery of Withaferin A for mitigating pulmonary metastasis.

Metastasis is the most challenging health problem contributing to about 90 % of cancer-related deaths worldwide. Metastatic tumors are highly aggressive and resistant to the most available therapeutic options. Hence, innovative therapeutic approaches are required to target metastatic tumors selectively.

Health Risks from Intake and Contact with Toxic Metal-Contaminated Water from Pager River, Uganda.

Pollution of water resources is one of the major impediments to the realization of Sustainable Development Goals, especially in developing countries. The aim of this study was to investigate the physicochemical quality and potentially toxic element (lead and cadmium) concentrations in surface water sampled from Pager River, a tributary of the Nile River in Northern Uganda. Water samples ( = 18) were taken from six different points upstream (A, B, and C) and downstream (D, E, and F) of the river and analyzed following standard methods for their physiochemical properties.

A Review on Bioactive Compounds, Ethnomedicinal Importance and Pharmacological Activities of Talinum triangulare (Jacq.) Willd.

Talinum triangulare (Jacq.) Willd. is a traditional leafy vegetable used by tribal communities for ethnomedicinal and ethnoculinary preparations.

Pan-genomic comparison of a potential solvent-tolerant alkaline protease-producing sp. TBG-PICH-001 isolated from a marine habitat.

Unlabelled: The identification and applicability of bacteria are inconclusive until comprehended with genomic repositories. Our isolate, sp. TBG-PICH-001 exhibited excellent halo- and organic solvent tolerance with simultaneous production of alkaline protease/s (0.

Dual-Functional Manganese-Doped ZnO-MOF Hybrid Material with Enhanced Hydrolytic Stability: A Fluorescent Photoinduced Electron Transfer Sensor for the Ultraselective Detection of Acetic Acid and Chromium (VI).

In recent years, the synthesis of metal-organic framework (MOF)─nanocomposites has received wide attention from the scientific fraternity due to the presence of a tunable hierarchical architecture and invasive versatility in applications. The present work focuses on the solvothermal synthesis of a novel hybrid MOF-nanocomposite through the impregnation of Mn-doped ZnO nanoparticles onto the matrix of a pioneer metal-organic framework that is composed of zinc metal connected with terephthalic acid linkers (MOF-5). The hierarchical arrangements of the prepared material were further assessed by Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), high-resolution transmission electron microscopy (HR-TEM), UV-visible, photoluminescence (PL), and dynamic light scattering (DLS) measurements.

discovery of novel calcineurin inhibitors using ligand-based 3-D pharmacophore modelling and molecular dynamics simulation.

Calcineurin is a serine-threonine protein phosphatase that is activated with the binding of calmodulin in the presence of increased calcium concentration and has a major role in various signaling pathways. Its role in regulating homeostasis, developmental processes, and different disease progression has already been reported. The dysregulated Ca/calcineurin/NFAT1-4 pathway is observed in Autoimmune disorders and hence the use of Calcineurin inhibitors like Cyclosporin A (CsA) and Tacrolimus (FK506) is widely done in such cases.

Electrooxidation of amoxicillin in aqueous solution with graphite electrodes: Optimization of degradation and deciphering of byproducts using HRMS.

Contaminants of emerging concern (CECs) such as antibiotics have become a matter of worry in aquatic environments worldwide. Their presence in the environment has been increasing due to the inability of conventional wastewater and water treatments to annihilate them. Hence, attempts have been made to remove CECs using electrochemical oxidation (EO).

Anthocyanins as Immunomodulatory Dietary Supplements: A Nutraceutical Perspective and Micro-/Nano-Strategies for Enhanced Bioavailability.

Anthocyanins (ACNs) have attracted considerable attention for their potential to modulate the immune system. Research has revealed their antioxidant and anti-inflammatory properties, which play a crucial role in immune regulation by influencing key immune cells, such as lymphocytes, macrophages, and dendritic cells. Moreover, ACNs contribute towards maintaining a balance between proinflammatory and anti-inflammatory cytokines, thus promoting immune health.