Investigation of pantoprazole loading and release from a magnetic-coated chitosan-modified zirconium-based metal-organic framework (MOF) as a nanocarrier in targeted drug delivery systems.

This study reports a novel magnetic and porous nanocomposite, FeO@CS@UIO-66-NH(Zr), developed by growing a zirconium-based metal-organic framework on magnetite-chitosan. It is designed for targeted and delayed pantoprazole delivery, the nanocomposite exhibits pH-sensitive behavior and functions as an efficient nanocarrier. The synthesis process involved coating magnetite nanoparticles with chitosan, followed by the growth of UIO-66-NH(Zr) on the coated nanoparticles.