1 results match your criteria: "University of Karachi Karachi 75270 Pakistan sumairajavaid17@yahoo.com sumaira.javed@iccs.edu hamramalik@gmail.com iqbal.choudhary@iccs.edu.[Affiliation]"
Identification of new leads against ubiquitin specific protease-7 (USP7): a step towards the potential treatment of cancers.
RSC Adv
October 2024
Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi Karachi 75270 Pakistan
Ubiquitin-specific protease-7 (USP7) is an important drug target as it regulates multiple proteins and genes (such as MDM2 and p53) with roles in cancer progression. Its inhibition can hinder the function of oncogenes, increase tumor suppression, and enhance immune response. The current study was designed to express USP7 in a prokaryotic system, followed by screening of small molecules against it using biophysical methods, primarily STD-NMR technique.
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