103 results match your criteria: "University of Kanazawa[Affiliation]"
Med Sci Sports Exerc
February 2002
Faculty of Pharmaceutical Sciences, University of Kanazawa, Kakuma, Kanazawa 920-1192, Japan.
Purpose: Clenbuterol is one of the beta-2 adrenergic receptor agonists with potent anabolic properties in muscles, yet the concomitant effects on muscle and bone in young animals remain to be resolved. Therefore, the purpose of this study was to determine the effects of clenbuterol administration on muscles and bones of young rats.
Methods: Twelve male Sprague-Dawley rats (9-wk-old) were randomly assigned to either a control (CON, N = 6) or clenbuterol group (CLE, N = 6).
Biol Sci Space
March 2001
Noto Marine Laboratory, University of Kanazawa, Ogi, Uchiura, Ishikawa, Japan.
On April 12, 1961, Major Yurii A. Gagarin of the former-U.S.
View Article and Find Full Text PDFJ Appl Physiol (1985)
July 2001
Faculty of Pharmaceutical Sciences, University of Kanazawa, Kakuma, Kanazawa 920-1192, Japan.
We hypothesized that a shift in muscle fiber type induced by clenbuterol would change monocarboxylate transporter 1 (MCT1) content and activity of lactate dehydrogenase (LDH) and isoform pattern and shift myosin heavy chain (MHC) pattern in soleus (Sol) and extensor digitorum longus (EDL) of male rats. In the clenbuterol-administered rats (2.0 mg x kg(-1) x day(-1) subcutaneously for 4 wk), the ratio of muscle weight to body weight increased in the Sol (P < 0.
View Article and Find Full Text PDFNeurosci Res
August 2000
Department of Molecular Neurobiology, Graduate School of Medicine, University of Kanazawa, Japan.
The goldfish optic nerve regenerates after sectioning. Recently both short-term (30 days) and long-term (4 months) recovery of various goldfish behaviors were observed after optic nerve section. Using intracellular injection of Lucifer Yellow (LY) the morphology of regenerating ganglion cells in goldfish retina after optic nerve section over a 4 month period have been investigated.
View Article and Find Full Text PDFBiochem Biophys Res Commun
March 2000
First Department of Internal Medicine & CREST, School of Medicine, University of Kanazawa, 13-1 Takara-Machi, Kanazawa, Ishikawa, 920-8641, Japan.
To investigate the gene expression profile of a normal human liver, we performed serial analysis of gene expression (SAGE), which allows the quantitative and simultaneous analysis of thousands of genes expressed in tissue. Polyadenylated RNA was obtained from a bulk normal human liver sample and SAGE was performed. Reverse transcriptase-polymerase chain reaction (RT-PCR) was also performed in each of 3 different normal liver samples to evaluate the validity of the profile in each individual.
View Article and Find Full Text PDFNeuroscience
October 1999
Department of Molecular Neurobiology, Graduate School of Medicine, University of Kanazawa, Japan.
As the goldfish is a common experimental animal for vision research, including psychophysical behavior, it is very important to quantitatively score fish behavior. We have previously developed a computer image processing system which can acquire the positional coordinates of goldfish moving freely in an aquarium and determine turning directions (go straight, right or left turn). In the present study, an algorithm to determine tilting angles of moving goldfish was constructed.
View Article and Find Full Text PDFNeuroscience
July 1999
Department of Molecular Neurobiology, Graduate School of Medicine, University of Kanazawa, Japan.
To investigate a physiological role of glutathione in the horizontal cells of carp retina, the gap junctional intercellular communication between horizontal cells was studied using the techniques of intracellular recording of light-induced responses and coupling of the fluorescence dye Lucifer Yellow. Intravitreal injection of 2.5 micromol L-buthionine sulfoximine, an inhibitor of glutathione synthesis, induced a dramatic reduction (20% of control) of retinal glutathione level two days after treatment.
View Article and Find Full Text PDFOral Surg Oral Med Oral Pathol Oral Radiol Endod
March 1998
Department of Oral and Maxillofacial Surgery, School of Medicine, University of Kanazawa, Ishikawa, Japan.
Objective: This study was designed to test the feasibility of several types of enhancements for cephalometric computed radiographs through use of the Fuji Computed Radiography system (Fuji Photo Film Corp., Tokyo, Japan).
Study Design: The material consisted of four lateral cephalograms made with the Fuji Computed Radiography system that were enhanced by varying the gradient levels before processing by means of both A-type (straight gradation) curves and workstation-type (peaked) curves.
Ann N Y Acad Sci
March 1997
Department of Physiology, University of Kanazawa Medical School, Japan.
In sum, our results indicate that LPS shock-associated hypothermia involves the following major mechanisms: 1) a decrease in the threshold Tb for activation of cold thermogenesis; 2) the resultant widening of the interthreshold zone; and 3) cold-seeking behavior. We speculate that, in severe systemic inflammation, this hypothermia constitutes an adaptive response.
View Article and Find Full Text PDFSpinal Cord
January 1997
Department of Orthopaedic Surgery, School of Medicine, University of Kanazawa, Japan.
Ring-shaped vasoconstrictions of arterioles at their branching sites have often been reported in vascular corrosion casts of the brain and spinal cord in rats and cats. It is surmised that smooth muscle cells in arteriolar walls could regulate the blood flow by changing the diameter of the lumen (ie vasomotion). However, few reports have described vasomotion at the capillary (capillaries have no smooth muscle cells).
View Article and Find Full Text PDFBehav Brain Res
October 1996
Department of Neurobiology, NIRI, University of Kanazawa, School of Medicine, Japan.
We developed a computer-image processing system to quantitatively score the goldfish behavior. The system was composed of two CCD cameras, set in the upper and side directions of a water tank, two graphics I/O boards (video interface) and an IBM PC/AT compatible computer. From the top and side views through the two CCD cameras, 2-dimensional or 3-dimensional positional coordinates of fish freely moving in an aquarium were acquired over a long period (60 min).
View Article and Find Full Text PDFNeuroscience
July 1996
Department of Laboratory Sciences, University of Kanazawa Faculty of Medicine, Japan.
We recently demonstrated that continuous L-glutamate exposure led to cell death in C6 glioma cells over a period of 24-36 h, due to inhibition of cystine uptake through the cystine/glutamate (XC) antiporter. The antioxidant vitamin E provided protection against this effect, supporting the hypothesis that depletion of glutathione might be responsible, resulting from insufficient cystine uptake. To clarify the content of oxidative stress after glutathione depletion, the present study was done to investigate accumulation and target molecules of reactive oxygen species induced by glutamate treatment.
View Article and Find Full Text PDFGastrointest Endosc
May 1995
Department of Internal Medicine, University of Kanazawa, Japan.
Giant gastric folds develop in several benign and malignant diseases. We used endoscopic ultrasonography to evaluate giant gastric folds in 15 patients with Borrmann type IV scirrhous carcinoma, 8 patients with gastric lymphoma, 5 patients with anisakiasis, 1 patient with Menetrier's disease, and 6 normal subjects with simple gastric hyperrugosity. With a 7.
View Article and Find Full Text PDFHepatogastroenterology
October 1994
Department of Surgery II, School of Medicine, University of Kanazawa, Ishikawa, Japan.
We have designed a variable loading cholangiomanometric method, which permits a precise and objective evaluation of distal bile duct function. Normal resistance (R) values (1-7 units) and residual pressure (P) values (50-150 mm H2O) have been defined by this method. We have performed this procedure on 138 patients with cholelithiasis, and have found that 13 patients with cholecystolithiasis and 14 patients with choledocholithiasis have elevated R and P values in the distal bile duct.
View Article and Find Full Text PDFTransplant Proc
August 1994
Department of Surgery II, School of Medicine, University of Kanazawa, Japan.
Neuroreport
April 1994
Department of Anatomy, Faculty of Medicine, University of Kanazawa, Japan.
It has been suggested that the expression of type 1 (gamma) protein kinase C(PKC) plays an active role in synaptogenesis. In situ hybridization assisted by an original computer image analysis technique (superimposition method) enabled the identification of PKC mRNA expression in the dendrite-rich neuropil area of the cerebellum. This study revealed prominent expression of PKC mRNA in the dendrite-rich neuropil area of the cerebellum at the critical period for synaptogenesis compared with adult mice cerebellum.
View Article and Find Full Text PDFNeuroscience
April 1994
Department of Neurobiology, University of Kanazawa School of Medicine, Ishikawa, Japan.
It was recently shown that addition of L-glutamate in millimolar amounts to a culture of C6 glioma cells induced cell death within 24 h. The mechanism for glutamate toxicity in the C6 glioma cells is linked to the inhibition of cystine uptake, leading to glutathione depletion through the cystine/glutamate antiporter (Xc) system. In the present study, neurotransmitters, whose receptors were localized on the glioma (glial) cells, were evaluated for their ability to protect C6 cells from glutamate toxicity through this amino acid antiporter.
View Article and Find Full Text PDFNeuroscience
March 1994
Department of Neurophysiology, University of Kanazawa School of Medicine, Japan.
Horizontal and amacrine cells in the isolated carp retina were impaled with micropipette electrode, identified by their characteristic light responses, and injected iontophoretically with markers for morphological study. Both Lucifer Yellow CH and biocytin were injected simultaneously. Lucifer Yellow was seen by its own fluorescence while biocytin was visualized by binding with Texas Red-linked or horseradish peroxidase-conjugated avidin.
View Article and Find Full Text PDFActa Neurochir Suppl (Wien)
December 1994
Department of Neurosurgery, School of Medicine, University of Kanazawa, Japan.
Perivascular spaces are anatomical routes for the bulk flow drainage of fluid from the gray matter to the subarachnoid space in normal rat brain. Perivascular cells are the resident scavengers in perivascular spaces. Following focal brain damage, perivascular cells upregulate MHC Class II antigens associated with uptake of edema fluid.
View Article and Find Full Text PDFJ Neurosurg
January 1994
Department of Neurosurgery, University of Kanazawa School of Medicine, Japan.
In order to clarify the cellular origin of craniopharyngiomas, the authors examined the distribution of P-glycoprotein (PGP) and human chorionic gonadotropin (HCG) in five normal adenohypophyses and in 23 craniopharyngiomas using peroxidase immunohistochemistry. The correlation between the expression of PGP in craniopharyngiomas and the recurrence of these tumors was also investigated. A number of pars intermedia cyst-lining cells immunostained positively for anti-PGP antibodies.
View Article and Find Full Text PDFNeuroscience
November 1993
Department of Neurobiology, NIRI, School of Medicine, University of Kanazawa, Japan.
A cytotoxicity of glutamate or related amino acids (10 mM) mediated by a cystine/glutamate antiporter (system Xc) has recently been demonstrated in N18 neuroblastoma-rat retina hybrid (N18RE105) cells and C6 glioma cells. The antiporter usually transports glutamate outside and cystine inside, thereby maintaining cellular concentrations of glutathione. High concentrations of glutamate inhibit cystine uptake and lead to depletion of cellular levels of glutathione.
View Article and Find Full Text PDFNeurosci Res
November 1993
Department of Neurophysiology, University of Kanazawa School of Medicine, Japan.
New rod photoreceptors are added to mature teleost retinas throughout life by regulated proliferation of rod precursor cells (RPCs). In this study, candidate regulators of RPC proliferation, acidic and basic fibroblast growth factors (aFGF and bFGF; 0.1 microgram/eye), interleukin-6 (IL-6; 0.
View Article and Find Full Text PDFTransplantation
September 1993
Department of Surgery II, School of Medicine, University of Kanazawa, Japan.
This study was performed to examine the immunosuppressive effect of a 5-lipoxygenase inhibitor, AA-861, on liver transplantation in rodents, and also to examine the production of eicosanoids during rejection of liver allograft in these animals. Rats were divided into three groups: group I (syngenic orthotopic liver transplantation from LEW to LEW), group II (allogenic OLT from ACI to LEW with dimethyl sulfoxide), and group III (allogenic OLT from ACI to LEW with AA-861 [20 mg/kg/day] s.c.
View Article and Find Full Text PDFRinsho Byori
May 1993
2nd Department of Internal Medicine, School of Medicine, University of Kanazawa.
Genetic hyperlipoproteinemias are produced by defects or abnormalities of several enzymes, apolipoproteins and transfer proteins relating to lipoprotein metabolism. Abnormalities of the LDL receptor cause familial hypercholesterolemia (FH) and the deficiency of cholesteryl-ester transfer protein (CETP) causes familial hyperalphalipoproteinemia. Here, abnormalities of the LDL-receptor genes and CETP gene are described.
View Article and Find Full Text PDFAtherosclerosis
April 1993
2nd Department of Internal Medicine, School of Medicine, University of Kanazawa, Japan.
Lipoprotein(a) (Lp(a)) was eliminated by LDL-apheresis using a dextran sulfate cellulose column in 3 homozygous and 10 heterozygous familial hypercholesterolemic patients. Immediately after LDL-apheresis by the LA-15 system (continuous LDL apheresis), there were significant reductions in Lp(a) concentrations (28.6 +/- 11.
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