Histopathological and Immunohistochemical Evaluation of Methotrexate-Induced Gonadal Damage in Rats: Role of SCF, mTOR, and SIRT-1.

Objective: Methotrexate (MTX) is a highly effective chemotherapy for cancer. This drug has a gonadotoxic effect, mainly in the testes and ovaries. Our study used histopathological and immunohistochemical methods to assess the potential damage to testicular and ovarian tissue caused by MTX use.

The Effect of a Mindfulness-Based Stress Reduction Program on Depression and Quality of Life in Cancer Patients: A Meta-Analysis Study.

Mindfulness-based interventions have been receiving growing attention in cancer care. This study was performed to determine the effect of a mindfulness-based stress reduction program on depression and quality of life in cancer patients. The screenings in the study were performed in January to May 2023 through the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, Web of Science, Science Direct, and YÖK Thesis Center databases.

The Effects of Acupressure and Massage on Pain, Menstrual Symptoms, and Quality of Life in Primary Dysmenorrhea: A Randomized Controlled Trial.

The study was carried out to determine the effects of acupressure and massage on pain severity, menstrual symptoms, and quality of life in patients with primary dysmenorrhea. This randomized controlled trial was conducted between January 2021 and May 2021. The study initially enrolled 309 female students with primary dysmenorrhea studying at a university in the Central Anatolia Region of Türkiye.

Chemical profiling and biological activity evaluation of propolis from Çayeli-Rize, Eastern Black Sea Region, Anatolia.

The constituents of the aqueous, ethanol, hexane, and methanol extracts of Anatolian propolis collected from the Eastern Black Sea Region (Çayeli-Rize) were investigated by GC-MS, HPLC and AAS. Interestingly, lactulose has been identified. Ten phenolic compounds, namely caffeic acid, ferulic acid, rutin, taxifolin, quercetin, kaempferol, apigenin, silicristin, silibinin and gallic acid were determined.

Investigation of integron gene cassettes in trimethoprim-sulfamethoxazole-resistant Acinetobacter baumannii isolates.

Background: The spread of antibiotic-resistance genes among healthcare-associated infections (HAIs) poses serious problems in the treatment of these infections. Recently, these resistance genes have also been shown to be present in integrons.

Objectives: By focusing on integron-mediated mechanisms of antibiotic resistance, we sought to elucidate the genetic determinants underpinning the development of multidrug resistance in clinical isolates of Acinetobacter baumannii.

The effectiveness of art-based interventions for cancer patients: A systematic review and meta-analysis.

Purpose: This study aimed to examine the effectiveness of art-based interventions on anxiety, depression, fatigue, and overall quality of life (QoL), including its physical, psychological, and social dimensions in cancer patients.

Methods: The literature search included all studies published up to March 2024. Searches were conducted in the MEDLINE, Web of Science, EBSCO, and PubMed databases considering the updated Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines.

Feasibility, reliability, and validity of the two-minute step test for assessing aerobic exercise capacity and functional endurance in participants with anterior cruciate ligament reconstruction.

The aim of this study was to investigate the feasibility, test-retest reliability, and construct validity of the 2-min step test (2MST) in measuring aerobic exercise capacity and functional endurance in participants with anterior cruciate ligament reconstruction (ACLR). Fifty participants with quadriceps tendon autograft, bone-patellar tendon-bone graft, or hamstring autograft were included. Feasibility was assessed by the time and support required to complete the measures and the feedback from participants, including their satisfaction ratings.

Effectiveness of mobilization with movement in patients operated for distal radius fracture: a single-blinded, randomized controlled study.

Objective: BACKGROUND: There are limited data on the use of Mulligan's mobilization with movement technique in patients who underwent surgery for distal radius fracture. AIMS: This study aimed to evaluate the effectiveness of adding Mulligan's mobilization with movement to the conventional exercise program for those who underwent open reduction and volar plate application due to distal radius fracture.

Methods: This randomized controlled, single-blind study was conducted with 53 patients who had been operated on for distal radius fracture.

Independent Association Between Malnutrition Inflammation Score and C Reactive Protein/Albumin Ratio in Hemodialysis Patients.

Introduction: This study aimed to investigate the relationship between the Malnutrition Inflammation Score (MIS) and the C-reactive protein/albumin ratio (CAR) in patients undergoing hemodialysis (HD).

Materials And Methods: Sixty-six End-Stage Renal Disease (ESRD) patients on maintenance hemodialysis were recruited for the study. Malnutrition Inflammation Score, biochemical parameters, and C-reactive protein/albumin ratio were analyzed.

A Comparison of Pelvic Floor Muscle Exercises and Spinal Stabilization Exercises in Women with Stress Urinary Incontinence.

Introduction And Hypothesis: The objective was to compare the effects of pelvic floor muscle exercise (PFME) and spinal stabilization exercise (SSE) on urinary symptoms, pelvic floor muscle strength (PFMS), quality of life (QoL), core stability, balance, spinal posture, and perception of subjective improvement (PSI) in women with stress urinary incontinence (SUI).

Methods: Patients were randomly divided into PFME (n = 25) and SSE (n = 25) groups. The exercises of both groups was applied 3 days a week for 8 weeks.

The effect of the use of artificial intelligence in the preparation of patient education materials by nursing students on the understandability, actionability and quality of the material: A randomized controlled trial.

Aim: This study was conducted to examine the effect of nursing students' use of artificial intelligence (AI) tools while preparing patient education materials on the understandability, actionability and quality of the material in terms of content.

Background: AI can significantly improve nursing students' learning experiences, helping them to be better prepared for the challenges of a rapidly changing healthcare environment. By ensuring that materials are prepared in accordance with students' individual learning styles, preferences and needs, AI can both improve the effectiveness of educational materials and contribute to better learning outcomes.

Comparative analysis of biofilm structures in Salmonella Typhimurium DMC4 strain and its dam and seqA gene mutants using Fourier transform infrared spectroscopy (FT-IR) and Raman spectroscopy methods.

It is well-established that the dam and seqA genes act in the biofilm production in Salmonella. However, the molecular basis underlying this activity remains unexplored. This study aims to address this gap in the literature.

The immunomodulator effect of Bertoni mediated by TNF-α and IL-1β in peripheral blood in diabetic rats.

Bertoni, which is a medicinal plant used in the treatment of diabetes, was the focus of this study aiming to investigate its immunomodulatory properties in diabetes. To form the diabetes group, rats were injected intraperitoneally with STZ and rats with blood glucose levels above 200 mg/dL 2 days after STZ injection were included in the diabetes group. To form the stevia and diabetes + stevia groups, stevia was administered daily by gavage to both healthy and diabetic rats for 28 days.

In vivo, In vitro, and In silico Studies of Umbelliferone and Irinotecan on MDA-MB-231 Breast Cancer Cell Line and Drosophila melanogaster Larvae.

Aims: Deaths from cancer are still very common all over the world and continue to be the focus of scientific research. Chemotherapy is one of the primary treatments used to prevent deaths from cancer. Side effects of chemotherapeutic drugs and resistance of cells to drugs are essential problems that limit the treatment process.

An investigation of machine learning algorithms for prediction of temporomandibular disorders by using clinical parameters.

This study aimed to predict temporomandibular disorder (TMD) using machine learning (ML) approaches based on measurement parameters that are practically acquired in clinical settings. 125 patients with TMD and 103 individuals without TMD were included in the study. Pain intensity (with visual analog scale), maximum mouth opening (MMO) and lateral excursion movements (with millimeter ruler), cervical range of motion (with goniometer), pressure pain threshold (PPT; with algometer), oral parafunctional behaviors (with Oral Behaviors Checklist), psychological status (with Hospital Anxiety and Depression Scale), and quality of life (with Oral Health Impact Profile) were evaluated.

The relationship between fragility scores and intraoperative body temperature changes in geriatric patients: Prospective observational research.

Today, to evaluate morbidity and mortality in elderly surgical patients, fragility scores, which reflect the patient's current condition rather than increasing age, are used as a basis. Our research examines the association between fragility groups, body temperature changes, and inadvertent perioperative hypothermia (IPH) in major orthopedic surgery patients. Patients over the age of 65 who underwent major orthopedic surgery were evaluated.

Predictive Significance of Laboratory Tests in Bacteremic Brucellosis.

Background: Brucellosis is one of the most common zoonotic infections. Although culture is the gold standard diagnostic method, bacterial growth in blood cultures may not always occur due to various factors. We aimed to investigate demographic, clinical, and laboratory findings that may have predictive significance for bacteremia in brucellosis.

Tractography analysis results of the trigeminus nerve, which contains fibers responsible for proprioception sensation and motor control in Adolescent Idiopathic Scoliosis.

Study Design: Cross-sectional Study.

Background: It is not yet clear whether the loss of proprioceptive sensation and muscle weakness seen in adolescent idiopathic scoliosis (AIS) is the result of central nervous system dysfunction or secondary to spinal deformity. In our study, in order to find an answer to this question, we examined the microarchitecture of the nervus trigeminus, which is least affected by spinal deformity and contains both proprioceptive sensory and motor fibers.

Differential diagnosis between recurrent disc herniation and granulation tissue after lumbar disc herniation Surgery: Qualitative analysis on MRI scans.

Background: Recurrence of disc herniation is a prevalent late-term complication among patients surgically treated for lumbar disc herniation. Differential diagnosis between recurrent disc herniation and granulation tissue can be achieved through signal intensity measurements on T2-weighted MRI examinations. This study aims to examine cases operated on for recurrence of lumbar disc herniation, assessing those presenting with either disc recurrence or granulation tissue.

Alpha B-crystallin Ameliorates Imbalance of Redox Homeostasis, Inflammation and Apoptosis in an Acute Lung Injury Model with Rats.

Objective: Ischemia-reperfusion (IR) of the aorta is a significant contributor to the development of postoperative acute lung damage after abdominal aortic surgery. The aim of the present study was to examine the effect of alpha B-crystallin, a small heat shock protein (known as HspB5), on lung injury induced by abdominal aortic IR in rats.

Methods: Male Sprague-Dawley rats were divided into three groups: control, ischemia-reperfusion (IR, 90 min ischemia and 180 min reperfusion), and alpha B-crystallin +IR.