4 results match your criteria: "University of Iowa and the Iowa City VA Medical Center[Affiliation]"
Role of prostaglandin F2α production in lipid bodies from Leishmania infantum chagasi: insights on virulence.
J Infect Dis
December 2014
Gonçalo Moniz Research Center, Oswaldo Cruz Foundation (FIOCRUZ) Federal University of Bahia (UFBA), Salvador, Bahia, Brazil Institute for Investigation in Immunology, iii-INCT (National Institute of Science and Technology), São Paulo, Brazil.
Lipid bodies (LB; lipid droplets) are cytoplasmic organelles involved in lipid metabolism. Mammalian LBs display an important role in host-pathogen interactions, but the role of parasite LBs in biosynthesis of prostaglandin F2α (PGF2α) has not been investigated. We report herein that LBs increased in abundance during development of Leishmania infantum chagasi to a virulent metacyclic stage, as did the expression of PGF2α synthase (PGFS).
View Article and Find Full Text PDFEvaluation of the adult with suspected immunodeficiency.
Am J Med
September 2007
Division of Allergy/Immunology, Department of Internal Medicine, University of Iowa and the Iowa City VA Medical Center, Iowa City 52242, USA.
Several primary immunodeficiencies may have their initial presentation in adulthood. Although recurrent infections are the hallmark of an underlying immunodeficiency, they need not be the presenting manifestation. This review highlights aspects of infections, as well as noninfectious diseases, that should prompt a high index of suspicion for an underlying immune disorder.
View Article and Find Full Text PDFNatural killer cells: emerging concepts in immunity to infection and implications for assessment of immunodeficiency.
Curr Opin Pediatr
December 2003
Departments of Pathology and Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa and the Iowa City VA Medical Center, Iowa City, Iowa 52242, USA.
Purpose Of Review: As the molecular networks that connect innate and adaptive immunity are untangled, the prominence of natural killer (NK) cells in host defense continues to emerge. Herein we highlight recent findings pertaining to NK cell development, trafficking, and interactions with other innate and adaptive immune cells in the context of predicting how NK cells may be involved in a wider range of clinical immunodeficiency.
Recent Findings: NK cells contribute vital roles in innate and adaptive immunity, especially in collaboration with dendritic cells (DC).
Objective: To examine the relationship of in-hospital and 30-day mortality rates and the association between in-hospital mortality and hospital discharge practices.
Data Sources/study Setting: A secondary analysis of data for 13,834 patients with congestive heart failure who were admitted to 30 hospitals in northeast Ohio in 1992-1994.
Design: A retrospective cohort study was conducted.