22,713 results match your criteria: "University of Iowa Hospital & Clinic[Affiliation]"

Purpose: This report compares device use in a cohort of Spanish-English bilingual and English monolingual children who are deaf and hard of hearing, including children fitted with traditional hearing aids, cochlear implants (CIs), and/or bone-conduction hearing devices.

Method: Participants were 84 Spanish-English bilingual children and 85 English monolingual children from clinical sites across the United States. The data represent a subset obtained in a larger clinical trial.

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Enhancing reproducibility in single cell research with biocytometry: An inter-laboratory study.

PLoS One

December 2024

Department of Research & Development, Sampling Human Inc., Berkeley, California, United States of America.

Article Synopsis
  • Biomedicine is moving towards decentralized data collection, which improves reproducibility and collaboration across labs.
  • A study evaluated biocytometry, a method using engineered bioparticles, and found it effective for counting target cells at low concentrations, even with varying user expertise.
  • The findings suggest that biocytometry is a practical option for immunophenotyping, allowing for sensitive and scalable analysis of rare cells in diverse samples without needing advanced training.
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Background This project investigates a music intervention to deprescribe antipsychotics in rural Veterans with dementia.  Methods The Veterans Health Administration Home-Based Primary Care Program is care provided in the home by an interdisciplinary team with the goals of decreasing hospitalizations and falls, providing education to patients and caregivers, and improving quality of life. Eighteen Home Based Primary Care Veterans with dementia and active antipsychotic prescriptions were identified with the goal to deprescribe antipsychotics in 50% of them using a music intervention.

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Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially life-threatening adverse drug reaction characterized by extensive skin rash in association with hematological abnormalities, including eosinophilia and atypical lymphocytosis, lymphadenopathy, fever, and extensive visceral organ involvement. Here, we presented a rare case of vancomycin-induced DRESS syndrome in a male who was treated with IV vancomycin for a brain abscess.

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Six-year duration of upper respiratory tract signs in a cat secondary to a draining tract from an incomplete enucleation in the left orbit.

Can Vet J

December 2024

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, 1800 Christensen Drive, Ames, Iowa 50011, USA (Diaz); Internal Medicine Department, Ottawa Animal Emergency and Specialty Hospital, 1155 Lola Street #201, Ottawa, Ontario K1K 4C1 (Milaszewska); Antech Diagnostics, 2616 Bank Street, Ottawa, Ontario K1T 1M9 (Labelle).

This case report describes a 10-year-old spayed female domestic medium-hair cat with chronic upper respiratory signs related to a remnant of the left globe in the orbit after incomplete enucleation, causing a draining tract. A CT scan, complete blood (cell) count, biochemical analysis, rhinoscopy, biopsy, culture, histopathologic analysis, and surgical revision of enucleation were done. Complete blood (cell) count was unremarkable.

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Retrospective evaluation of the influence of phenoxybenzamine pretreatment on intraoperative cardiovascular variables in dogs with pheochromocytoma.

Can Vet J

December 2024

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa, USA (Willette); Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA (Bini, Selmic); Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA (Traverson); Capital City Specialty & Emergency Animal Hospital, Ottawa, Ontario (Liptak); College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA (Hollenbeck); Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA (Maxwell, de Mello Souza); College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA (Wustefeld-Janssens).

Objective: To compare cardiovascular outcomes in dogs undergoing adrenalectomy for pheochromocytoma with and without phenoxybenzamine pretreatment.

Animals: A total of 65 medical records from dogs at 5 veterinary hospitals.

Procedure: Records from January 2004 to December 2021 were evaluated for systolic, mean, and diastolic arterial pressures; numbers of hypertensive and hypotensive episodes; highest and lowest systolic arterial pressure differences; dose and duration of phenoxybenzamine; and presence of intraoperative arrhythmias.

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Article Synopsis
  • This study analyzed decisions regarding decompressive hemicraniectomy (DHC) and early withdrawal of life-sustaining therapy (WLST) in patients with large vessel occlusion (LVO) and large ischemic strokes from the SELECT2 trial.* -
  • Among 352 patients, DHC was utilized in 55 patients, and WLST was chosen for 81, showing no significant differences in usage between those receiving endovascular thrombectomy (EVT) and those treated medically.* -
  • About 21% of DHC patients were able to walk independently after one year, indicating that DHC did not negatively impact the benefits of thrombectomy, while WLST generally resulted in poor outcomes.*
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This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.

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Article Synopsis
  • The text discusses the importance of forecasting future health issues in the USA for effective planning and public awareness regarding disease and injury burdens.
  • It describes the methodology for predicting life expectancy, cause-specific mortality, and disability-adjusted life-years (DALYs) from 2022 to 2050 using the Global Burden of Diseases framework.
  • The forecasting includes various scenarios to assess the potential impacts of health risks and improvements across the country, focusing on demographic trends and health-related risk factors.
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Influence of Common Medications on Diabetic Macular Edema in Type 2 Diabetes Mellitus.

Ophthalmol Retina

December 2024

Ruiz Department of Ophthalmology and Visual Science, University of Texas Health Science Center, Houston, TX, USA. Electronic address:

Purpose: This study aimed to assess the impact of systemic medications, including GLP-1 receptor agonists (GLP-1 RAs), fenofibrates, thiazolidinediones (TZDs), and calcium channel blockers (CCBs), on the risk of developing diabetic macular edema (DME) in patients with type 2 diabetes mellitus (T2DM).

Design: A retrospective cohort study was conducted using electronic medical records (EMR) data from the TriNetX health research network, covering a period from October 2004-2024.

Participants: The study population comprised patients diagnosed with T2DM who were newly initiated on GLP-1 RAs, fenofibrates, TZDs, or CCBs.

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Background: Previous studies suggest that early developmental delay is a common feature of Juvenile-Onset Huntington's disease (JOHD), with highest incidence in those with very high CAG repeats (> 80). However, all reports of developmental delay in JOHD are exclusively based on retrospective review of medical charts. Comprehensive assessment of birth history metrics may provide better insight into the question of early life development in JOHD.

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Heavy menstrual bleeding clinics for adolescents.

Hematology Am Soc Hematol Educ Program

December 2024

Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA.

Heavy menstrual bleeding (HMB) is a common symptom in adolescence, often leading to significant disruptions in daily life, such as school absences, shame caused by the stigma surrounding menstruation, and symptoms from iron deficiency. Further, HMB may be the first and/or only sign of an underlying bleeding disorder. Navigating the symptoms, effects, and treatments of HMB during adolescence requires a collaborative approach between the patient, caregivers, and healthcare providers.

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Visual processing involves numerous neuro-ophthalmic pathways that enable humans to perceive and interact with the world. These visual pathways can negatively impact visual perception and decision-making. The Vestibulo-Ocular Reflex (VOR) is a compensatory mechanism that stabilizes gaze on a target during head movement, such as running or turning.

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Background: Spetzler-Martin (SM) Grade III brain arteriovenous malformations (BAVMs) represent a transitional risk zone between low- and high-grade BAVMs, characterized by diverse angioarchitecture. The primary treatment options are endovascular embolization, microsurgical resection (MS), and stereotactic radiosurgery (SRS). This study compares the efficacy and outcomes of MS and SRS.

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» Suture button fixation has emerged as an effective surgical construct in arthroscopic and open Latarjet and anterior glenoid reconstruction with free autograft bone with high rates of bone block healing.» Biomechanical data suggest that screw and suture button mechanical fixation constructs provide similar load to failure and stability for the Latarjet procedure.» Preliminary bone healing models have identified that flexible fixation may exhibit a higher degree of bone callus maturation, whereas rigid fixation results in excessive callus hyperplasia» Mechanical tensioner use provides consistent tensioning of suture button constructs and improves bone-to-bone healing rates when used for anterior glenoid reconstruction surgery.

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Predictive Value of Right Ventricular Sensing During Cardiac Device Implantation to Diagnose Cardiac Amyloidosis.

JACC Clin Electrophysiol

November 2024

Department of Cardiology, University Hospital Henri Mondor, Assistance Publique-Hôpitaux de Paris, Creteil, France; Groupe de Recherche Clinique, Amyloid Research Institute and Clinical Epidemiology of Ageing, Institut Mondor de Recherche Biomédicale U955, Creteil, France. Electronic address:

Background: Cardiac amyloidosis (CA) is an underdiagnosed disease, often presenting with electrical conduction abnormalities or ventricular arrhythmias, prompting implantation of cardiac implantable electrical devices (CIEDs).

Objectives: This study sought to evaluate the performance of right ventricular sensing (RVSens) during implantation of CIEDs in patients presenting with increased left ventricular (LV) wall thicknesses (ILVWT) and preserved LV function to predict the diagnosis of CA.

Methods: All consecutive patients with ILVWT (maximal LV wall thickness ≥12 mm), preserved LV function and no significant aortic stenosis who underwent implantation of CIEDs at 2 French referral centers for rare and inheritable cardiac diseases were retrospectively evaluated.

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Esophageal cancer, particularly squamous cell carcinoma, poses significant diagnostic challenges due to its aggressive nature and similarity to metaplastic tissue. Accurate diagnosis often requires multiple biopsies and vigilant surveillance, especially in high-risk individuals with conditions such as gastroesophageal reflux disease (GERD) and a history of smoking. We present a 66-year-old female patient with a history of severe GERD and smoking, who underwent routine endoscopy revealing a gastric cardia nodule.

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Article Synopsis
  • Patients who have undergone solid organ transplants are at higher risk for severe COVID-19 due to immunosuppressive therapy, necessitating better vaccination and treatment strategies.
  • A study assessed the outcomes of liver and kidney transplant recipients diagnosed with COVID-19, focusing on factors like vaccine doses and monoclonal antibody (mAb) therapy.
  • Results showed that while some vaccine doses had no impact, liver transplant patients on mycophenolate had significantly higher mortality rates, and those receiving mAb therapy had lower hospitalization rates, highlighting the need for tailored treatment approaches in this vulnerable group.*
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Article Synopsis
  • Permanent pacemaker placement is necessary for newborns with congenital complete heart block (CCHB), but existing devices may not fit well, causing complications.
  • Medtronic has created a smaller Pediatric Implantable Pulse Generator (IPG) that uses a bipolar lead, making it more suitable for neonates.
  • This case report details a minimally invasive method for implanting the new Pediatric IPG in a 2.32 kg newborn soon after birth.
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Unlabelled: Clostridioides difficile infection is the most common healthcare-associated infection, causing almost half a million infections in the United States annually. Inappropriate antibiotic usage is a known risk factor. Antibiotic stewardship efforts aim to optimize prescribing.

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Background: The identification of a heterozygous exonic GGC repeat expansion in ZFHX3 underlying spinocerebellar ataxia type 4 (SCA4) has solved a 25-year diagnostic conundrum. We used adaptive long-read sequencing to decipher the pathogenic expansion in the index Utah family and an unrelated family from Iowa of Swedish ancestry. Contemporaneous to our discovery, other groups identified the same repeat expansion in affected individuals from Utah, Sweden, and Germany, highlighting the current pivotal time for detection of novel repeat expansion disorders.

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Rationale And Objective: Acute kidney injury (AKI) is a common complication among hospitalized adults, but AKI prediction and prevention among adults has proved challenging. We used machine learning to update the nephrotoxic injury negated by just-in time action (NINJA), a pediatric program that predicts nephrotoxic AKI, to improve accuracy among adults.

Study Design: A retrospective cohort study.

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Article Synopsis
  • Ductal carcinoma in-situ (DCIS) is a non-invasive breast cancer type that makes up about 25% of breast cancer cases, but it often leads to unnecessary aggressive treatment despite many cases never progressing to invasive cancer.
  • A study analyzed 197 breast tissue samples to explore molecular changes in DCIS, using techniques like mRNA expression and DNA analysis to compare progressing versus non-progressing cases.
  • The research found significant molecular differences among DCIS subtypes and between DCIS and invasive breast cancer, highlighting the complexity of DCIS and the need for more tailored approaches to assess risk and treatment.
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