Effect of Fluoride Varnishes on Demineralization and Acid Resistance in Subsurface Demineralized Lesion Models.

This study aimed to clarify the effects of high-concentration fluoride varnish application on the inhibition of the progression of initial enamel caries. Remineralization capacity and acid resistance following high-concentration fluoride varnish application were compared with untreated models and models treated with fluoride mouthwash. Bovine enamel was used to create a model of initial enamel caries.

Comparing Polymerization Shrinkage Measurement Methods for Universal Shade Flowable Resin-Based Composites.

Universal shade flowable composites have been introduced to mimic tooth structure with reduced color mismatch and reduced chair time and cost. However, the polymerization shrinkage of resin material may lead to sensitivity and restoration failure. The purpose of this study was to compare the polymerization shrinkage of recently introduced universal shade flowable resin-based composites using both wet and dry density methods.

Exogenous bone sialoprotein improves extraction socket healing in ibsp knockout and wild-type mice.

Bone sialoprotein (Ibsp/BSP) is a bone-associated extracellular matrix protein. Ibsp knockout (Ibsp) mice exhibit defective alveolar bone formation, mineralization, and healing. We hypothesized BSP would rescue defective alveolar bone healing in a molar extraction model in Ibsp mice.

SOX2-induced IL1α-mediated immune suppression drives epithelial dysplasia malignant transformation.

Squamous cell carcinomas (SCC) are often preceded by potentially malignant precursor lesions, most of which remain benign. The terminal exhaustion phenotypes of effector T-cells and the accumulation of myeloid-derived suppressor cells (MDSC) have been thoroughly characterized in established SCC. However, it is unclear what precancerous lesions harbor a bona fide high risk for malignant transformation and how precancerous epithelial dysplasia drives the immune system to the point of no return.

Aesthetic Clinical Case for Immediate Implant Therapy for Maxillary Central Incisor.

This case report features a female patient with the chief complaint of needing to replace an anterior crown. After a comprehensive oral assessment and cone beam computed tomography (CBCT) radiographic examination, it was determined that the crown on Tooth #9 was subgingivally fractured. The procedure involved atraumatic extraction of Tooth #9, followed by immediate implant placement.

Dental Dam Isolation for Crown Removal, Atraumatic Tooth Extraction, Immediate Implant Placement, and Restoration Cementation: A Case Study.

Objectives: This case report describes the clinical protocols for the removal of crowns, tooth extraction, immediate implant placement, and cementation of new crowns, all performed under total or partial isolation with a dental dam.

Clinical Considerations: The patient's chief complaint was dissatisfaction with her smile. Radiographic and clinical evaluations led to the recommendation to replace the porcelain-fused-to-metal crowns on the maxillary central and lateral incisors with all-ceramic crowns.

Effect of CAD/CAM Abutment Morphology on the Outcomes of Implant Therapy: A Randomized Controlled Trial.

Objectives: Variations in transmucosal abutment contour design may affect the outcomes of implant therapy. This randomized controlled trial was primarily aimed at testing the effect that CAD/CAM zirconia abutments with either a concave or linear divergent transmucosal morphology have on peri-implant mucosal dynamics and indicators of peri-implant health at 1 year after final implant-supported prosthesis insertion in the anterior maxilla.

Materials And Methods: Following computer-guided implant placement and osseointegration, eligible subjects were randomized into either the experimental (concave morphology) or the control (linear divergent morphology) group.

DNA and RNA Methylation in Periodontal and Peri-implant Diseases.

Periodontal and peri-implant diseases are primarily biofilm-induced pathologies in susceptible hosts affecting the periodontium and dental implants. Differences in disease susceptibility, severity, and patterns of progression have been attributed to immune regulatory mechanisms such as epigenetics. DNA methylation is an essential epigenetic mechanism governing gene expression that plays pivotal roles in genomic imprinting, chromosomal stability, apoptosis, and aging.

Ageism combating strategies in oral healthcare: A systematic review.

Purpose: The aim of this study is to investigate the existing evidence regarding the effectiveness of strategies aimed at combating ageism against older adults among dental students.

Methods: A systematic review was performed following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines to identify articles from seven electronic databases: MEDLINE via the PubMed interface, Embase, Age-Line, Scopus, Web of Science, CINAHL, and Cochrane.

Results: Among twenty-four references reporting on ageism among oral health care providers and/or students, only two reported on the outcomes of strategies for combating ageism at dental schools, with a 12-year gap between them.

Multi-omic analyses of a twin pair with mirror image cleft lip identifies pathogenic variant in modified by differential methylation upstream of .

Background: Disturbances in the intricate processes that control craniofacial morphogenesis can result in birth defects, most common of which are orofacial clefts (OFCs). Nonsyndromic cleft lip (nsCL), one of the phenotypic forms amongst OFCs, has a non-random laterality presentation with the left side being affected twice as often compared to the right side. This study investigates the etiology of nsCL and the factors contributing to its laterality using a pair of monozygotic twins with mirror-image cleft lip.

Evaluation of the Staff Educational Components of the PROMOTE Program to Improve Resident Hydration.

Background/objectives: Inadequate fluid intake is prevalent among older adults living in care settings and can lead to dehydration-related events such as falls and hospitalization. Staff knowledge and confidence using diverse strategies is needed to provide adequate hydration to residents. PROMOTE is a multicomponent intervention designed to support staff to increase resident fluid intake between meals.

Quantifying the Strain: A Global Burden of Disease (GBD) Perspective on Musculoskeletal Disorders in the United States Over Three Decades: 1990-2019.

Musculoskeletal (MSK) disorders significantly contribute to global disability, especially in high-income countries. Yet, comprehensive studies on their epidemiological burden in the United States (US) are limited. Our study aims to fill this gap by characterizing the MSK disease burden in the US using Global Burden of Disease (GBD) data from 1990 to 2019.

Color Stability of Bulk-Fill Flowable Resin Composites After Artificial Aging.

Background: This study aimed to evaluate the color stability of bulk-fill flowable resin composites with 2 difference shades at baseline and after artificial aging.

Methods: Disk-shaped specimens (Ø10 × 4 mm) were fabricated from three bulk-fill flowable resin resin composites (Filtek Bulk-Fill Flow, Venus Bulk-Fill Flow, and Estelite Bulk-Fill Flow). The specimens in each bulk-fill resin composite group were divided into two subgroups (n = 10 per subgroup) with two different shades, A1 (N = 30) and A3 (N = 30), and were polymerized with light curing (800 mW/cm/Valo LED Unit, Ultradent) and polished.

Exploring the obstacles affecting the oral health of adolescents with intellectual disabilities: insights from maternal perspectives-a qualitative study.

Background: Oral health plays a critical role in overall well-being, particularly among adolescents, including those with intellectual disabilities. Caregivers, particularly mothers, play an essential role in guiding and supporting these adolescents in maintaining good oral health. This study examined the oral health problems and challenges faced by children with intellectual disabilities from the perspective of their mothers.

Ultrasonographic Evaluation of Vascular Response to Mechanical Compression during Induced Gingival Inflammation.

The aim of this study was to evaluate the gingival vascular response to mechanical compression during inflammation using ultrasonography. Four female and 4 male Sinclair mini pigs 18 mo of age were included in the study. Pathogenic bacteria-impregnated silk ligatures were placed around the third premolars (PM3), fourth premolars (PM4), and first molars (M1).

Effect of different types of tooth and post space lengths on the accuracy of the digital post space with intraoral scanning.

Statement Of Problem: To create custom posts for endodontically treated teeth with a digital workflow, clinical guidelines governing digital scan techniques are needed. However, the evidence for the accuracy of intraoral scanners (IOSs) is limited for different tooth types and post space lengths.

Purpose: The purpose of this in vitro study was to evaluate the trueness of post space scans made with 2 different IOSs for various tooth types and post space lengths.

Navigating Esthetic Challenges: Immediate Implant Placement and Comprehensive Restorative Solutions-A Clinical Case With 2-Year Follow-Up Study.

The esthetics of immediate implant dentistry can be challenging. Clinical considerations for immediate implant placement have demonstrated long-term success rates comparable to traditional delayed implant protocols. However, it is a sensitive technique that requires proper treatment planning as well as meticulous execution to be predictable and successful in the long term.

The HYdrocortisone for Bronchopulmonary Dysplasia Respiratory and Developmental (HYBRiD) outcomes study: protocol for a longitudinal cohort study.

Background: Bronchopulmonary dysplasia (BPD) affects up to half of extremely preterm infants, and is associated with adverse long-term respiratory, neurodevelopmental, and educational sequelae and costly health service and family economic outcomes. The NICHD Neonatal Research Network Hydrocortisone for Bronchopulmonary Dysplasia (BPD) Trial evaluated the efficacy and safety of hydrocortisone treatment to prevent BPD in high-risk infants. The trial enrolled 800 very preterm infants with respiratory failure and followed the participants until 2 years corrected age to assess safety of the trial intervention.

Geriatric dentistry course effect against ageism among dental students: A cohort study.

Purpose: The aim of this study is to investigate the effectiveness of geriatric dentistry courses as a combating strategy against ageism among dental students.

Methods: A pre-post prospective study was conducted in three different dental schools located in the State of Sao Paulo, Brazil, that offered geriatric dentistry courses in their curricula. A questionnaire specifically developed for this research and the "Ageism Scale for Dental Students" (ASDS) were applied before and after geriatric dentistry courses in all three dental schools.

Longevity of glass ionomer restorations in an older adult population.

Objectives: This study investigates longevity of glass ionomer restorations in an older adult population.

Methods: This was a retrospective study based on clinical records. Patient records for 3,665 restorations in 1,777 adults 65 or older who had received a restoration between 12th July 2016 and 20th October 2022 were extracted from the electronic dental records system of the University of Iowa College of Dentistry and Dental Clinics.