2,782 results match your criteria: "University of Indonesia.[Affiliation]"

Aim: This study aimed to explore the strategies and important components that can be implemented to build adolescent awareness about stunting prevention.

Methods: This study used descriptive qualitative design. The data were collected through focus group discussions (FGDs) and semi-structured interviews.

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A meta-analysis of technology-based interventions on treatment adherence and treatment success among TBC patients.

PLoS One

December 2024

Research Center for Pre-Clinical and Clinical Medicine, National Research and Innovation Agency, Cibinong Science Center, Cibinong, West Java, Indonesia.

Various technology-based interventions have been designed to improve medication adherence and treatment success. However, research on the most effective mode to address this issue is still limited. Our study evaluated the effectiveness of technology-based interventions in improving treatment adherence, completion, and treatment success among tuberculosis (TBC) patients.

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Article Synopsis
  • - The research analyzes four mannanase enzymes to understand their structure and stability in different pH environments using in silico methods like molecular dynamics simulations and homology modeling.
  • - Findings indicated unique traits for each enzyme, pointing to their viability for various industrial uses.
  • - The study highlighted how specific mutations in key residues significantly influence enzyme performance across different pH levels.
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  • Indonesia is experiencing H9N2 avian influenza, and this study examined the molecular characteristics of recent isolates from West Java using advanced techniques like RT-qPCR and Sanger sequencing.
  • The analysis revealed that the new virus isolate has 11 amino acid changes compared to a previous isolate, maintaining its connection to the h9.4.2.5 subclade, while showing a specific mutation at antigenic site II.
  • Molecular docking studies indicated that the recent isolate prefers binding to sialic acid found in mammals, which could have implications for the virus's behavior and transmission.
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  • The study investigates the effects of anticoagulant therapy on vascular and visual function in patients with NAION, a complex eye disorder.
  • Both hypercoagulable and non-hypercoagulable groups received daily aspirin, with the hypercoagulable group also receiving warfarin.
  • Results showed that patients in the hypercoagulation group had significant visual field improvements, suggesting that anticoagulant therapy could help slow down disease progression and improve clinical outcomes.
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Purpose: Urolithiasis and symptomatic ureterolithiasis represent diseases known to be on the increase in most westernized countries. The present article aims to give an overview on some drug principles assumed to target signalling systems involved in modulating ureter smooth muscle contractility and to present background to their potential use or prospects in ureter stone disease.

Methods: The article reviews drugs that have been evaluated over the last decades in vitro, in vivo and/or in clinical settings with regard to their properties to achieve spontaneous passage of (distal) ureteral stones and relieve colic pain.

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Unlocking the wound-healing potential: An integrative in silico proteomics and in vivo analysis of Tacorin, a bioactive protein fraction from Ananas comosus (L.) Merr. Stem.

Biochim Biophys Acta Proteins Proteom

January 2025

Dexa Laboratories of Biomolecular Sciences, PT Dexa Medica, Jababeka Industrial Estate II, Jl. Industri Selatan V Blok PP No. 7 Cikarang, 17550, Indonesia; Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, South Jakarta 12930, Indonesia. Electronic address:

Tacorin, a bioactive protein fraction derived from pineapple stem (Ananas comosus), has emerged as a promising therapeutic agent for wound healing. This study employs an integrated approach, combining in silico proteomics and in vivo investigations, to unravel the molecular mechanisms underlying Tacorin's wound healing properties. In the domain of in silico proteomics, the composition of Tacorin is elucidated through LC/MS-MS protein sequencing, revealing ananain (23.

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  • Breast cancer has become the most common cancer worldwide, with metastatic cancer being the leading cause of death related to this disease, prompting the development of early detection methods using non-invasive biomarkers.
  • Exosomes, which are tiny vesicles released by cancer cells, play a crucial role in transmitting signals and contain noncoding RNAs (ncRNAs) like miRNAs, lncRNAs, and circRNAs that influence various aspects of breast cancer progression, including growth, metastasis, and immune responses.
  • The study examines the regulatory mechanisms of exosomes in breast cancer and aims to enhance understanding of the functions of exosomal ncRNAs to identify potential biomarkers and improve treatment strategies.
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Background: Diabetic Foot Ulcer (DFU) might be worsened by neuropathy and vascular issues. This condition can cause 14.3% fatality, stressing the need for effective wound healing therapy.

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  • The study investigates the "obesity paradox" in COPD patients, focusing on how body mass index (BMI) relates to mortality rates.
  • A systematic review of 120 studies showed that while being underweight increases mortality risk, being overweight or obese is associated with lower mortality risk, establishing a U-shaped relationship with BMI.
  • The research highlights specific BMI inflection points where the protective benefits begin to decline, indicating that extremely high BMI values can negate these benefits in relation to various types of mortality.
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Background: Early pregnancy ultrasound provides a more accurate estimate of the estimated delivery date (EDD) than the last menstrual period (LMP). However, LMP-based EDD calculation remains common in resource-limited settings. Inaccurate EDDs can contribute to adverse birth outcomes.

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  • Cytogenetics plays a critical role in diagnosing and predicting outcomes for myelodysplastic syndrome (MDS), with specific profiles indicating a higher risk of progression to acute myeloid leukemia (AML).
  • This study focused on Indonesian patients with MDS, assessing their cytogenetic profiles through clinical examinations and follow-ups over one year.
  • Key findings included the identification of monosomy 7 and chromosome 5 deletions in certain patients, along with a notable risk of AML transformation in those with MDS-EB.
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Background And Objectives: A novel antitubercular cyclic peptide, Cyclo(1,6)-Ac-CLYHFC-NH, was designed to bind at the rifampicin (RIF) binding site on the RNA polymerase (RNAP) of (MTB). This peptide inhibits RNA elongation in the MTB transcription initiation assay in the nanomolar range, which can halt the MTB transcription initiation complex, similar to RIF. Therefore, determining the solution conformation of this peptide is useful in improving the peptide's binding affinity to the RNAP.

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Minimizing food oxidation using aromatic polymer: From lignin into nano-lignin.

Food Res Int

December 2024

Department of Agroindustrial Technology, Faculty of Agricultural Engineering and Technology, IPB University, Bogor 16680, Indonesia; Department of Chemical Engineering, Faculty of Engineering, University of Indonesia, Depok 16424, Indonesia.

Food loss and waste caused by oxidation result in environmental and economic losses and health threats. Lignin is an abundant aromatic polymer with varied antioxidant capacity, which can reduce food oxidation caused by radical species exposure. The lignin antioxidant strength can be influenced by source, type, structure, processing, degradation products, chemical modifications, and particle size.

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Factors on medical clerkship students' quality of life: A survey study.

J Public Health Res

October 2024

Department of Psychiatry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.

Introduction: Due to the higher demand for healthcare provision in Indonesia, increasing the number of medical schools in Indonesia was highly encouraged. Meanwhile, medical students were considered a susceptible population to a variety of issues that negatively impact their quality of life (QOL) in comparison to the general community.

Objectives: The study aims to assess the QOL of Indonesian medical students during the clinical clerkship program (years 4-5) of their medical training while also exploring the association between the results and their ongoing rotation.

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A Revolutionary Device for Endovascular Aortic Repair of Abdominal Aortic Aneurysm: A Pilot Study.

F1000Res

November 2024

Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Indonesia, University of Indonesia Academic Hospital, National Cardiovascular Center Harapan Kita, Jakarta, Jakarta, 11420, Indonesia.

Article Synopsis
  • Endovascular repair for abdominal aortic aneurysms (AAA) has been the preferred method since 1991, with new techniques like contralateral gate cannulation being developed to enhance the process.
  • A new device called the Taofan and Kang (T&K) bidirectional endovascular aortic repair (B-EVAR) was introduced, utilizing a unique approach to deploy stent grafts through both femoral arteries while ensuring safety and effectiveness.
  • In a pilot study involving six patients, the T&K B-EVAR showed promising results with no complications or prolonged hospital stays, indicating it simplifies the AAA repair process and could be beneficial for a wider range of patients.
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The optimal duration of antibiotic prophylaxis for patients undergoing primary hip or knee arthroplasty remains debated. We conducted a systematic review and meta-analysis to compare the outcomes of single-dose versus extended antibiotic prophylaxis. Studies assessing these strategies for periprosthetic joint infection (PJI), revision surgery, and superficial surgical site infections were selected from systematic searches in PubMed, Embase, and the Cochrane Library.

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Enterotoxigenic Escherichia coli (ETEC)-mediated diarrhea can be mitigated by inhibiting bacterial adhesion to intestinal surface. Some lactic acid bacteria (LAB) produce exopolysaccharides (EPS) that can inhibit ETEC adhesion. In this study, we fermented soy flour-based dough (SoyD) with EPS-producing LAB strains Pediococcus pentosaceus TL (PpTL), Leuconostoc citreum TR (LcTR), Leuconostoc mesenteroides WA (LmWA) and L.

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  • AI-based endoscopy, particularly cystoscopy, helps urologists identify cancerous areas effectively by using deep learning algorithms trained on large datasets of medical images.
  • A review of multiple databases found five studies that demonstrated AI's impressive sensitivity (0.953) and specificity (0.957) in detecting bladder cancer when compared to traditional histopathology.
  • While AI's application in bladder cancer detection shows promise, further research is needed to validate and enhance its effectiveness in clinical practice.
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Background: From previous studies, evaluation of post-anastomosis draining-vein volume flow rate with Doppler ultrasound can be a predictor for arteriovenous fistula maturation. Due to the high variation in measurements by the effect of probe pressure in draining vein, measuring volume flow rate based on post-anastomosis feeding-artery may be an early alternative predictor of arteriovenous fistula maturation. This study aims to investigate the correlation of post-creation brachial artery volume flow rate on maturity of brachiocephalic arteriovenous fistula access in patients with end-stage kidney disease with diabetes mellitus.

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Are Social Media Notifications Distracting?

Exp Psychol

July 2024

Amsterdam School of Communication Research, University of Amsterdam, The Netherlands.

Visual working memory (VWM), due to its temporary nature, is highly volatile. VWM encoding may be easily disrupted by cues from our visually rich media environment, such as social media logos and notification badges. Yet, to what extent these social media-related cues adversely affect our cognitive processing is not well understood.

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Objectives: Food products are often contaminated by pathogens and spoilage bacteria. Most of them can form biofilms, a community of cells embedded in protective extracellular matrix layers resistant to harsh conditions, including antibiotics. Therefore, alternative antibiofilm agents are required to overcome biofilm formation.

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Background: Occupational safety hazards include physical, chemical, ergonomic, biological, and psychological hazards. Technological innovation in screening for occupational stress, especially among female workers, is needed to improve their health and productivity.

Objective: This research is being conducted to obtain a prediction model of work stress through a questionnaire instrument that includes stressors and symptoms based on the transactional model, as well as measurement of work stress through a mobile app that can be used anywhere.

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Introduction: Bladder leiomyomas (LM) are uncommon, non-cancerous growths that originate from the smooth muscle cells of the bladder and constitute 0.5% of bladder tumor cases. This review aims to compile existing data and present a summary of bladder leiomyomas' characteristics, management, and related outcomes.

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