Gestational low protein diet selectively induces the amino acid response pathway target genes in the liver of offspring rats through transcription factor binding and histone modifications.

The amino acid response (AAR) pathway detects a deficiency of dietary amino acid or protein. To investigate the impact of gestational protein restriction on the AAR pathway in offspring, pregnant Sprague-Dawley rats were fed a control (C) or low protein (LP) diet during gestation. Livers of female offspring were collected on postnatal d 38.

Inverse scattering for optical coherence tomography.

Inverse scattering theory for optical coherence tomography (OCT) is developed. The results are used to produce algorithms to resolve three-dimensional object structure, taking into account the finite beam width, diffraction, and defocusing effects. The resolution normally achieved only in the focal plane of the OCT system is shown to be available for all illuminated depths in the object without moving the focal plane.

Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains.

The entry of human immunodeficiency virus type 1 (HIV-1) into the cell is initiated by the interaction of the viral surface envelope protein with two cell surface components of the target cell, CD4 and a chemokine coreceptor, usually CXCR4 or CCR5. The natural ligand of CXCR4 is stromal cell-derived factor 1alpha (SDF-1alpha). Whereas the overlap between HIV-1 and SDF-1alpha functional sites on the extracellular domains of CXCR4 has been well documented, it has yet to be determined whether there are sites in the transmembrane (TM) helices of CXCR4 important for HIV-1 and/or SDF-1alpha functions, and if such sites do exist, whether they are overlapping or distinctive for the separate functions of CXCR4.

Environmental support for older and younger pilots' comprehension of air traffic control information.

We investigated whether expertise mitigates age differences on pilot communication tasks when experts rely on environmental support. Pilots and nonpilots listened to air traffic control messages describing a route through an airspace, during which they referred to a chart of the airspace. The routes were high (waypoint routes anchored to navigational reference points on the chart) or low (vector routes that were not) in contextual support.