2 results match your criteria: "University of Illinois at Chicago College of Medicine. dougl@uic.edu.[Affiliation]"
Metabolic efficiency promotes protection from pressure overload in hearts expressing slow skeletal troponin I.
Circ Heart Fail
January 2015
From the Center for Cardiovascular Research and Department of Physiology and Biophysics, University of Illinois at Chicago College of Medicine.
Background: The failing heart displays increased glycolytic flux that is not matched by a commensurate increase in glucose oxidation. This mismatch induces increased anaplerotic flux and inefficient glucose metabolism. We previously found adult transgenic mouse hearts expressing the fetal troponin I isoform, (ssTnI) to be protected from ischemia by increased glycolysis.
View Article and Find Full Text PDFIs the therapeutic window for mitochondrial ROS half-open or half-closed? Mixing mitophagic metaphors.
Circ Res
July 2014
From the Program in Integrative Cardiac Metabolism, Center for Cardiovascular Research (A.N.C., E.D.L.) and Department of Physiology and Biophysics (A.N.C., E.D.L.), University of Illinois at Chicago College of Medicine.