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Prognosis of Myocardial Damage in Sarcoidosis Patients With Preserved Left Ventricular Ejection Fraction: Risk Stratification Using Cardiovascular Magnetic Resonance.

Circ Cardiovasc Imaging

January 2016

From the Departments of Medicine (G.M., L.J.L., F.M., C.A.B., A.V.P., Z.Y., K.A., V.M.-A., J.D.M., D.K.H., R.M.L., A.R.P.) and Radiology (R.M.L., A.R.P.), University of Chicago, IL; Department of Medicine, Mayo Clinic, Phoenix, AZ (J.F.B.); and Department of Medicine, University of Illinois at Chicago (N.J.S.).

Background: Cardiac sarcoidosis is associated with an increased risk of heart failure and sudden death, but its risk in patients with preserved left ventricular ejection fraction is unknown. Using cardiovascular magnetic resonance in patients with extracardiac sarcoidosis and preserved left ventricular ejection fraction, we sought to (1) determine the prevalence of cardiac sarcoidosis or associated myocardial damage, defined by the presence of late gadolinium enhancement (LGE), (2) quantify their risk of death/ventricular tachycardia (VT), and (3) identify imaging-based covariates that predict who is at greatest risk of death/VT.

Methods And Results: Parameters of left and right ventricular function and LGE burden were measured in 205 patients with left ventricular ejection fraction >50% and extracardiac sarcoidosis who underwent cardiovascular magnetic resonance for LGE evaluation.

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