Neighborhood-level deprivation and survival in lung cancer.

Background: Despite recent advances in lung cancer therapeutics and improving overall survival, disparities persist among socially disadvantaged populations. This study aims to determine the effects of neighborhood deprivation indices (NDI) on lung cancer mortality. This is a multicenter retrospective cohort study assessing the relationship between NDI and overall survival adjusted for age, disease stage, and DNA methylation among biopsy-proven lung cancer patients.

Presence of variable extrathoracic airflow limitation in patients with a negative methacholine challenge test.

Purpose: Determine whether variable extrathoracic airflow limitation (VEAL) is observed in patients with negative methacholine challenge tests (MCT).

Methods: Electronic medical records of patients undergoing MCT at Jesse Brown VA Medical Center between January 2017 and December 2019 were reviewed. Only patients with negative MCT were selected.

Trisomy 18: disparities of care and outcomes in the State of Texas between 2009 and 2019.

Objective: To perform a statewide characteristics and outcomes analysis of the Trisomy 18 (T18) population and explore the potential impact of associated congenital heart disease (CHD) and congenital heart surgery.

Study Design: Retrospective review of the Texas Hospital Inpatient Discharge Public Use Data File between 2009 and 2019, analysing discharges of patients with T18 identified using ICD-9/10 codes. Discharges were linked to analyse patients.

Recognizing and Dismantling Raciolinguistic Hierarchies in Latinx Health.

Latinx individuals represent a linguistically and racially diverse, growing US patient population. Raciolinguistics considers intersections of language and race, prioritizes lived experiences of non-English speakers, and can help clinicians more deftly conceptualize heterogeneity and complexity in Latinx health experiences. This article discusses how raciolinguistic hierarchies (ie, practices of attaching social value to some languages but not others) can undermine the quality of Latinx patients' health experiences.

Eliminating Explicit and Implicit Biases in Health Care: Evidence and Research Needs.

Health care providers hold negative explicit and implicit biases against marginalized groups of people such as racial and ethnic minoritized populations. These biases permeate the health care system and affect patients via patient-clinician communication, clinical decision making, and institutionalized practices. Addressing bias remains a fundamental professional responsibility of those accountable for the health and wellness of our populations.

Enough Is Enough.

In this cartoon, a guilt-ridden and heavily scarred surgeon prepares to self-flagellate to atone for his team's failed attempts to save the life of an innocent child victim of a mass shooting. One of his nurses, carrying an assault rifle modified to serve as his whip, attempts to stop him by reminding him that the blame is not his to bear. We in the field of medicine can and must do more for our patients than simply treating their wounds and consoling their families and loved ones after tragic, senseless losses.

Management of Rodenticide Poisoning Associated with Synthetic Cannabinoids.

Synthetic cannabinoids may be adulterated with potent vitamin K antagonists, which should be considered if a patient presents with unexplained coagulopathy, widespread bleeding, and a history of synthetic cannabinoid use.

Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?

It is becoming increasingly clear that mitochondria drive cellular functions and in vivo phenotypes by directing the production rate and abundance of metabolites that are proposed to function as signaling molecules (Chandel 2015; Selak et al. 2005; Etchegaray and Mostoslavsky 2016). Many of these metabolites are intermediates that make up cellular metabolism, part of which occur in mitochondria (i.

Should Mental Health Screening and Psychotherapy Be Required Prior to Body Modification for Gender Expression?

Some people want to modify their bodies through hormonal and surgical treatments in order to resolve gender dysphoria, the distress they experience when their bodies do not align with their gender identity. The World Professional Association for Transgender Health (WPATH) offers guidelines to clinicians regarding treatment of people wanting to modify their bodies for this reason. Prior to these modifications, WPATH advises that mental health screening is needed and that psychotherapy is recommended though not a requirement.

Fuzzy logic and causal reasoning with an 'n' of 1 for diagnosis and treatment of the stroke patient.

The current scientific model for clinical decision-making is founded on binary or Aristotelian logic, classical set theory and probability-based statistics. Evidence-based medicine has been established as the basis for clinical recommendations. There is a problem with this scientific model when the physician must diagnose and treat the individual patient.