1 results match your criteria: "University of Illinois College of Medicine (J.L.). abmalik@uic.edu.[Affiliation]"
Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury.
Circ Res
October 2017
From the Department of Pharmacology (M.M., S.N., Y.T., C.M.H., D.S., J.L., C.T., A.B.M.), and Department of Medicine, University of Illinois College of Medicine (J.L.).
Rationale: TRPM2 (transient receptor potential melastatin-2) expressed in endothelial cells (ECs) is a cation channel mediating Ca entry in response to intracellular generation of adenosine diphosphoribose-the TRPM2 ligand.
Objective: Because polymorphonuclear neutrophils (PMN) interaction with ECs generates reactive oxygen species, we addressed the possible role of TRPM2 expressed in ECs in the mechanism of transendothelial migration of PMNs.
Methods And Results: We observed defective PMN transmigration in response to lipopolysaccharide challenge in adult mice in which the EC expressed TRPM2 is conditionally deleted ( ).