Molecular clustering on ctDNA improves the prognostic stratification of DLBCL patients compared to ctDNA levels.

Circulating tumor DNA (ctDNA) levels can help predict outcomes in diffuse large B-cell lymphoma (DLBCL), but its integration with DLBCL molecular clusters remains unexplored. Using the LymphGen tool in 77 DLBCL with both ctDNA and tissue biopsy, a 95.8% concordance rate in molecular cluster assignment was observed, showing the reproducibility of molecular clustering on ctDNA.

Implications of scale up flexible plastic packaging recycling in the United States.

Flexible plastic packaging (FPP) is a growing waste source in the United States. Currently, FPP has a recycling rate of only 2% in the U.S.

A Rare Combination of Bleeding Disorders in South Dakota: A Case Report.

Hemophilia A is a clotting disorder due to factor VIII deficiency, leading to prolonged bleeding. Acquired hemophilia A results from the immune system attacking factor VIII, typically occurring later in life. Factor V Leiden is a genetic mutation causing abnormal blood clot formation, primarily in veins.

Evaluation of Probiotic Effects on the Growth Performance and Microbiome of Nile Tilapia () in a High-Density Biofloc System.

Biofloc technology is an aquaculture production system that has gained popularity with tilapia production. Probiotics provide benefits for the host and/or aquatic environments by both regulating and modulating microbial communities and their metabolites. When a probiotic feed is combined with a biofloc system, the production amount may be improved through better fish growth, disease resistance, and/or improved water quality by reducing organic matter and stabilizing metrics such as pH and components of the nitrogen cycle.

Phthalate esters in water and sediment of Asunle stream of Obafemi Awolowo University, Ile-Ife, Nigeria: Distribution and human health risks.

This study determined the concentrations and seasonal variations of phthalate esters (PAEs) in water and sediment samples of the receiving stream within the vicinity of the Obafemi Awolowo University, Ile-Ife dumpsite. The objective of this study was to evaluate the pollution status of the study area by determining the levels of PAEs in water and sediment samples. This assessment aimed to understand the presence and extent of phthalate ester pollution in the study area.

Exploring the Maximum Potential of Initiating Ability in Metal-Free Primary Explosives.

Lead azide (LA) is a widely utilized primary explosive, serving as the initiating charge in blasting caps or detonators to start the detonation process of secondary explosives. The toxicity and environmental concerns associated with LA have led to regulatory restrictions and increased scrutiny, prompting the search for lead-free alternatives. LA is highly sensitive toward heat, shock, or friction, which poses safety challenges during manufacturing, handling, and storage.

Barriers to Nursing School Admissions for Students With Physical or Sensory Disabilities: Do Essential Abilities Requirements Align With Licensure Standards and Legal Precedence?

Aim: The aim of the study was to examine sensory and motor essential abilities required by nursing boards and assess their inclusion in prelicensure nursing program admissions.

Background: The nursing workforce should mirror diverse patient populations for better concordance; however, essential abilities restrictions hinder admissions for students with disabilities.

Method: Requirements for licensure were collected from state boards of nursing and compared with essential abilities admissions requirements from 58 prelicensure programs.

Physiological and Psychological Differences Between 20% Grade Incline Walking and Level-Grade Jogging at Isocaloric Intensity.

High-incline walking is a relatively new trend with little comparative information. This study compared physiological and psychological differences between high-incline walking at 20% grade (HIW) and level-grade jogging (LGJ) at isocaloric intensities in young adults. Twenty-two participants (M = 11, F = 11) aged 19-31 years completed the study.

A fundamental rheological approach to determine the optimum water absorption capacity of a model gluten-free dough system: soy flour dough.

Background: Determining the optimum water absorption capacity of gluten-free flours for an improved breadmaking process has been a challenge because there is no standard method. In the present study, large amplitude oscillatory shear (LAOS) tests were performed to explore the impact of different levels of added water on non-linear viscoelastic response of soy flour dough in comparison to wheat flour dough at a consistency of 500 BU.

Results: Among the LAOS parameters, large strain modulus (G') and large strain rate viscosity (η') were found to better probe the impact of added water amount on non-linear viscoelastic properties of soy flour dough.

Continuing anti-EGFR monoclonal antibody after secondary resection significantly prolongs overall survival for patients with metastatic colorectal cancer who were responsive to first-line anti-EGFR monoclonal antibody plus chemotherapy doublet.

The combination of anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAb) and doublet chemotherapy is the standard first-line treatment for patients with wild-type metastatic colorectal cancer (mCRC). Some patients may require secondary resection after first-line treatment. However, it remains unclear whether targeted therapy should be continued after liver resection.

Seamless Navigation of Bispecific Therapies: Optimizing Management and Outpatient Access With a Focus on Coordination.

Bispecific antibodies (BsAbs) have emerged as crucial therapeutic agents for patients with relapsed/refractory diffuse large B-cell lymphoma, multiple myeloma, and most recently, lung cancer. These therapies have demonstrated remarkable efficacy in clinical trials; however, multidisciplinary collaboration is essential to ensure optimal patient outcomes amid the operational complexities associated with BsAb therapy. As BsAbs are being prepared for broader adoption, clinicians and treatment centers must navigate operational challenges, including financial considerations, patient selection, caregiver involvement, and transitions of care.

Hypercalcaemia in association with Sertoli cell tumour in a dog.

A 9-year-old, presumed male castrated mixed breed dog was evaluated for lethargy, hyporexia, polyuria, polydipsia and diffuse gynaecomastia. Bloodwork revealed severe hypercalcaemia and hyposthenuria. CT scan showed a caudal abdominal mass consistent with a Sertoli cell tumour on cytology.

Dataset of tensile properties for sub-sized specimens of nuclear structural materials.

Mechanical testing with sub-sized specimens plays an important role in the nuclear industry, facilitating tests in confined experimental spaces with lower irradiation levels and accelerating the qualification of new materials. The reduced size of specimens results in different material behavior at the microscale, mesoscale, and macroscale, in comparison to standard-sized specimens, which is referred to as the "specimen size effect." Although analytical models have been proposed to correlate the properties of sub-sized specimens to standard-sized specimens, these models lack broad applicability across different materials and testing conditions.

Mechanical Properties of Eye Lens Cortical and Nuclear Membranes and the Whole Lens.

Purpose: To elucidate the mechanical properties of the bovine lens cortical membrane (CM), the nuclear membrane (NM) containing cholesterol bilayer domains (CBDs), and whole bovine lenses.

Methods: The total lipids (lipids plus cholesterol) from the cortex and nucleus of a single bovine lens were isolated using the monophasic methanol extraction method. Supported CMs and NMs were prepared from total lipids extracted from the cortex and nucleus, respectively, using a rapid solvent exchange method and probe-tip sonication, followed by the fusion of unilamellar vesicles on a flat, freshly cleaved mica surface.

Enhancing Medical Student Engagement Through Cinematic Clinical Narratives: Multimodal Generative AI-Based Mixed Methods Study.

Background: Medical students often struggle to engage with and retain complex pharmacology topics during their preclinical education. Traditional teaching methods can lead to passive learning and poor long-term retention of critical concepts.

Objective: This study aims to enhance the teaching of clinical pharmacology in medical school by using a multimodal generative artificial intelligence (genAI) approach to create compelling, cinematic clinical narratives (CCNs).

Impact of Older Adults' Internet Use on Economic Burden of Informal Caregiving.

This study examines the impact of older adults' Internet use on care hours and its influence on estimating national cost savings with active and potential Internet users. Using data from the 2015 National Health and Aging Trends Study ( = 1,806), we employed a survey weighted two-part model with gamma distribution. The cost savings were estimated by a replacement approach.

Evaluation of color in digital nuclear power plant control room displays.

Human system interface design in industrial process control is guided by industry standards, human factors best practices, and domain-specific conventions, and often there is a conflict between one or more of the sources of design input for specific design elements. In the nuclear domain, one design element for which conflict arises is the use of color to represent equipment state. This study evaluates the tradeoffs associated with using color in a process control display versus using white and shades of gray.

Exploring Canadian Dietitians' Knowledge Attitude and Practices Providing Culturally Safe Care to Muslims who fast During the Month of Ramadan: A Cross-sectional Study.

Fasting during Ramadan involves abstaining from food and drink from dawn to dusk for 29 to 30 days, annually. Dietitians, experts in food and nutrition, play a vital role in fostering the well-being of Canadians. Given that 1 in 20 Canadians are Muslim, access to culturally safe care is essential for their health.

Gyrfalcon Prey Abundance and Their Habitat Associations in a Changing Arctic.

Arctic habitats are changing rapidly and altering trophic webs and ecosystem functioning. Understanding how species' abundances and distributions differ among Arctic habitats is important in predicting future species shifts and trophic-web consequences. We aimed to determine the habitat-abundance relationships for three small herbivores on the Seward Peninsula of Alaska, USA by fitting data from 983 point counts (collected during 2019, 2021, and 2022) with N-mixture models that account for imperfect detection.