Prosthetic rehabilitation of a hemimaxillectomy patient using a zygomatic - Corticobasal® implant- supported reconstructive prosthesis: A case report.

Introduction: Rehabilitation of patients with hemimaxillectomy presents a challenge. This case report describes the successful use of zygomatic Corticobasal® implant- supported reconstructed prosthesis.

Clinical Case Presentation: A 20-year-old female patient presented to the clinic following hemimaxillectomy with soft tissue approximation one year ago.

Influence of mothers' and frontline health workers' knowledge, attitude, and practices on infant and young child feeding and child nutrition: a cross-sectional study in aspirational districts of Assam, India.

The knowledge, attitude, and practices (KAP) of mothers and frontline health workers (FLWs) regarding optimal Infant and Young Child Feeding (IYCF) are essential for mitigating undernutrition and associated morbidities among under-five children. The study assessed the KAP of mothers (of children aged 0-60 months) and FLWs regarding recommended IYCF practices, the association of mother's KAP with their demographic characteristics and children's nutritional outcomes, and the prevalence of stunting, wasting, and underweight among children aged 0-60 months in five high-focus districts of Assam. Data were collected from 389 mothers, 456 children, and 138 FLWs using a standard method.

Immune complexes-mediated activation of neutrophils in systemic lupus erythematosus is dependent on RNA recognition by toll-like receptor 8.

Introduction: Neutrophil activation is important in systemic lupus erythematosus (SLE). We previously demonstrated that ribonucleoprotein (RNP) immune complexes (ICs) promoted neutrophil activation in a TLR7/8-dependent manner. However, it remains unclear if this mechanism occurs in patients.

Establishment and perturbation of human gut microbiome: common trends and variations between Indian and global populations.

Human gut microbial species are crucial for dietary metabolism and biosynthesis of micronutrients. Digested products are utilised by the host as well as several gut bacterial species. These species are influenced by various factors such as diet, age, geographical location, and ethnicity.

Nanoscale self-assembly and water retention properties of silk fibroin-riboflavin hydrogel.

Silk-fibroin hydrogels have gained considerable attention in recent years for their versatile biomedical applications. The physical properties of a complex hydrogel, comprising silk fibroin and riboflavin, surpass those of the silk fibroin-hydrogel without additives. This study investigates silk fibroin-riboflavin (silk-RIB) hydrogel at the atomistic level to uncover molecular structures and chemical characteristics specific to silk fibroin and riboflavin molecules in an aqueous medium.

Xalnesiran with or without an Immunomodulator in Chronic Hepatitis B.

Background: Xalnesiran, a small interfering RNA molecule that targets a conserved region of the hepatitis B virus (HBV) genome and silences multiple HBV transcripts, may have efficacy, with or without an immunomodulator, in patients with chronic HBV infection.

Methods: We conducted a phase 2, multicenter, randomized, controlled, adaptive, open-label platform trial that included the evaluation of 48 weeks of treatment with xalnesiran at a dose of 100 mg (group 1), xalnesiran at a dose of 200 mg (group 2), xalnesiran at a dose of 200 mg plus 150 mg of ruzotolimod (group 3), xalnesiran at a dose of 200 mg plus 180 μg of pegylated interferon alfa-2a (group 4), or a nucleoside or nucleotide analogue (NA) alone (group 5) in participants with chronic HBV infection who had virologic suppression with NA therapy. The primary efficacy end point was hepatitis B surface antigen (HBsAg) loss (HBsAg level, <0.

Mechanistic insights into gut microbe derived siderophores and PHD2 interactions with implications for HIF-1α stabilization.

In oxygen-deprived conditions, cells respond by activating adaptive mechanisms to bolster their survival and protect tissue integrity. A key player in this process is the HIF-1α signaling cascade, meticulously regulated by Prolyl Hydroxylase Domain 2 (PHD2), which orchestrates cellular responses to varying oxygen levels. The primary aim of this investigation is to utilize gut siderophores as inhibitors of PHD2 in ischemic conditions.

Design of Spurious Dynamic Inverter-Based Level Shifter with Error Tolerance for Robotic Arm Controller.

In robotic arm controllers, the ability to shift signal levels is crucial for interfacing between different voltage domains in a processor. The level shifter (LS) has been used to convert signals operating near threshold voltage to signals operating well above the threshold voltage. Researchers have developed current mirror-based LSs to employ current mirrors, which duplicate the current from one transistor and accurately replicate it in another, ensuring precise current matching.

Endoscopic Ultrasound-Guided Pancreatic Tissue Sampling: Lesion Assessment, Needles, and Techniques.

Endoscopic ultrasound (EUS)-guided tissue sampling includes the techniques of fine needle aspiration (FNA) and fine needle biopsy (FNB), and both procedures have revolutionized specimen collection from the gastrointestinal tract, especially from remote/inaccessible organs. EUS-FNB has replaced FNA as the procedure of choice for tissue acquisition in solid pancreatic lesions (SPLs) across various society guidelines. FNB specimens provide a larger histological tissue core (preserving tissue architecture) with fewer needle passes, and this is extremely relevant in today's era of precision and personalized molecular medicine.

Effect of Metformin on Meibomian Gland Epithelial Cells: Implications in Aging and Diabetic Dry Eye Disease.

Background: Metformin, a commonly prescribed medication for managing diabetes, has garnered increasing interest as a potential therapeutic option for combating cancer and aging.

Methods: The current study investigated the effects of metformin treatment on human meibomian gland epithelial cells (hMGECs) at morphological, molecular, and electron microscopy levels. HMGECs were stimulated in vitro with 1 mM, 5 mM, and 10 mM metformin for 24, 48, and 72 h.

Targeting Refractory Triple-Negative Breast Cancer with Sacituzumab Govitecan: A New Era in Precision Medicine.

Advanced triple-negative breast cancer (TNBC) has poorer outcomes due to its aggressive behavior and restricted therapeutic options. While therapies like checkpoint inhibitors and PARP inhibitors offer some benefits, chemotherapy remains ineffective beyond the first line of treatment. Antibody-drug conjugates (ADCs) like sacituzumab govitecan-hziy (SG) represent a significant advancement.

Detection of Disease Features on Retinal OCT Scans Using RETFound.

Eye diseases such as age-related macular degeneration (AMD) are major causes of irreversible vision loss. Early and accurate detection of these diseases is essential for effective management. Optical coherence tomography (OCT) imaging provides clinicians with in vivo, cross-sectional views of the retina, enabling the identification of key pathological features.

Assessing Educational Impact of Worldwide Webinar on Management of Myopia Progression in Children.

Objective: To assess the educational impact of a worldwide webinar approach to myopia progression management in children <8 years and 8-12 years old.

Design: Cross-sectional study.

Methods: A self-administered survey was conducted for attendees of a 3 h worldwide webinar held in two parts on consecutive days on the management of myopia progression in children.

Muscle-Specific Effects of Genotype, Animal Age, and Wet Aging Duration on Beef Color, Tenderness, and Sensory Characteristics.

This study investigated the effects of genotype, animal age, muscle type, and aging duration on meat quality characteristics of (PM), (LT), (LL), and (GM) muscles. The PM, LT, LL, and GM muscles were sourced from a total of 32 bulls, consisting of 16 humped () and 16 humpless ( × ) bulls aged 21 ± 2 and 30 ± 3 months. The muscles underwent aging durations of 0, 7, and 14 days.

Exploration of magnetic zeolite thin film derived from coal fly ash an efficient sorbent: Application to water treatment.

Fly ash, produced during coal combustion for energy making, which is recognized as an industrial by-product, could lead to environmental health hazards. Subsequently, fly ash found that an exceptional adsorption performance for the removal of various toxic pollutants, the adsorption capacity of fly ash might be altered by introducing physical/chemical stimulation. Successfully converting fly ash into zeolites not only recovers their disposal difficulties but also transforms unwanted materials into merchandisable products for various industrial applications.

Lung cancer in Asia: the impact of climate change.

The escalating global threat of climate change is becoming more evident. The climate crisis intersects with another major challenge: lung cancer. With Asia already bearing half the global cancer burden, the impact of climate-related events on health and on lung cancer care specifically are profound.

Erratum to "The importance of sleep studies in improving the health indices of a nation" [Sleep Med: X 4 (2022) 100049].

[This corrects the article DOI: 10.1016/j.sleepx.

Josephson diode effect in one-dimensional quantum wires connected to superconductors with mixed singlet-triplet pairing.

The Josephson diode effect (JDE), characterized by asymmetric critical currents in a Josephson junction, has drawn considerable attention in the field of condensed matter physics. We investigate the conditions under which JDE can manifest in a one-dimensional Josephson junction composed of a spin-orbit-coupled quantum wire with an applied Zeeman field, connected between two superconductors (SCs). Our study reveals that while spin-orbit coupling (SOC) and a Zeeman field in the quantum wire are not sufficient to induce JDE when the SCs are purely singlet, introduction of triplet pairing in the SCs leads to the emergence of JDE.

A-site composition tuning in methylammonium-based metal halide perovskite colloidal nanocrystals.

Utilizing the soft-lattice nature of metal halide perovskites, we employ post-synthetic cross-ion exchange to synthesize a series of narrow band-gap colloidal nanocrystals of methylammonium-based lead iodide solid solutions of composition FAMAPbI, as well as those of triple-cation composition CsFAMAPbI (TCPbI). The ability to finely tune the compositions not only helps in tailoring the optical properties in the near-infrared region, but also improves the stability of these colloidal nanocrystals towards moisture, which has been demonstrated as compared to their bulk counterparts. The thermal stability of these solid solutions is also comparable to that of the bulk, as evidenced by thermogravimetric studies.

Tuning the properties of soy protein isolate-based adhesive using various sustainable additives.

This work investigates the adhesive property of Soy Protein Isolate (SPI) polymer solution by studying mechanical properties of composites formed using waste wood granules and SPI solutions. To improve the adhesive strength of SPI solution, Carboxymethyl Cellulose Sodium (NaCMC) was mixed (in the weight ratios of 9:1 and 8:2) due to its strong gel formation capabilities. The adhesive performance of these composites was further investigated in the presence and absence of non-toxic additives, including sorbitol (SOR) and stearic acid (SA).

"Comparison of the efficacy of Erich arch bars, IMF screws and SMART Lock Hybrid arch bars in the management of mandibular fractures- A Randomized clinical study".

Purpose: The purpose of this study was to assess and compare the efficacy of Erich Arch Bar (EAB), Inter Maxillary Fixation (IMF) screws and SMART Lock Hybrid arch bar (HABs) in the treatment of mandibular fractures.

Materials And Methods: A prospective randomized clinical study was carried out in the Department of Dentistry at ESIC Hospital in Hyderabad from August 2021 to August 2023. The study comprised of three groups (EAB group (31), IMF screw group (33) and HABs group (29)).

Morphology controlled CuBiS nanostructures: superior electrocatalytic sensing of organic nitro compounds.

Addressing the pressing need to develop affordable and efficient catalysts is essential. In this study, we successfully synthesized CuBiS nanostructures with a modified morphology using three different nitrogen bases: DBN, DBU, and DABCO a hydrothermal technique. These nanostructures were used for the electrochemical detection of organic nitro groups, a previously unexplored application for this material.

Does "swapping" maize ( L.) inbred parents affect hybrid grain yield? - a seed production research case study.

Maize ( L.) is a globally important crop, thriving across diverse environments. Breeding maize inbreds with good combining ability for stable yields under both optimal and stress-prone conditions has been successful.

Enhancing intraoral radiographic technique: introducing "Nallan's Lines".

Background: Intraoral radiography remains the most widely employed dental radiographic technique for producing geometrically accurate images with minimal distortion and magnification. Despite its common use in the dental office, incorrect projection geometry can be challenging leading to image distortions. To mitigate these inaccuracies specific radiographic landmarks on the face are utilized during periapical radiography.