Effect of pH on the toxicity of fumonisins towards the RTL-W1 cell line and zebrafish (Danio rerio) embryos.

Fumonisins are common contaminants of maize. The neutral red assay, using the RTL-W1 trout liver cell line, and the fish embryo test (FET), using zebrafish, were selected to assess the effect of pH on the cytotoxicity, acute toxicity and teratogenicity of fumonisin B (FB). The results demonstrated that FB exerts low cytotoxicity towards RTL-W1 cells without pH adjustment (IC 1 746 μM), and no cytotoxicity after pH-adjustment to physiological conditions.