Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort study.

Purpose: The objective of the current research was to assess the clinicopathological characteristics and long-term prognosis of triple-negative breast cancer (TNBC) patients with human epidermal growth factor receptor 2 (HER2)-low status following breast surgery.

Methods: A total of 202 TNBC patients treated at Qingdao Central Hospital from January 2010 to December 2019 were included, comprising 71 HER2-low and 131 HER2-zero patients. Propensity score matching (PSM) was applied to minimize differences between the cohorts.

The Predictive Value of tPSA, fPSA, fPSA/tPSA Combined with Ultrasound Parameters in Postoperative Gleason Grading of Prostate Cancer.

Aim: Prostate cancer (PCa) is a common malignant tumor in men. This study aimed to explore the predictive value of serum biomarkers combined with ultrasound parameters for postoperative Gleason grading in PCa.

Methods: This study included 65 PCa patients who underwent transurethral resection of the prostate in our hospital from January 2021 to December 2023.

[Effect of retrograde dissection of the facial nerve along the mandibular margin on postoperative quality of life in patients with benign superficial parotid tumors].

Purpose: To assess the impact of retrograde dissection of the facial nerve along the mandibular margin on the postoperative quality of life in patients with benign superficial parotid tumors.

Methods: One hundred and sixteen patients who underwent surgical treatment for benign superficial parotid tumors at Qingdao Central Hospital from January 2020 to January 2023 were involved. The patients were randomly allocated into two groups, with 58 patients in each group using the touch ball method.

The Combination of Aligned PDA-Fe@PLCL Conduit with Aligned GelMA Hydrogel Promotes Peripheral Nerve Regeneration.

Biomaterial-assisted therapeutic strategies enable precise modulation to direct endogenous cellular responses and harness regenerative capabilities for nerve repair. However, achieving effective cellular engagement during nerve remodeling remains challenging. Herein, a novel composite nerve guidance conduit (NGC), the GelMA/PLys@PDA-Fe@PLCL conduit is developed by combining aligned poly(l-lactide-co-caprolactone) (PLCL) nanofibers modified with polydopamine (PDA), ferrous iron (Fe⁺), and polylysine (PLys) with aligned methacrylate-anhydride gelatin (GelMA) hydrogel nanofibers.

ZO-1 boosts the in vitro self-renewal of pre-haematopoietic stem cells from OCT4-reprogrammed human hair follicle mesenchymal stem cells through cytoskeleton remodeling.

Background: The challenge of expanding haematopoietic stem/progenitor cells (HSPCs) in vitro has limited their clinical application. Human hair follicle mesenchymal stem cells (hHFMSCs) can be reprogrammed to generate intermediate stem cells by transducing OCT4 (hHFMSCs) and pre-inducing with FLT3LG/SCF, and differentiated into erythrocytes. These intermediate cells exhibit gene expression patterns similar to pre-HSCs, making them promising for artificial haematopoiesis.

Lnc_011797 promotes ferroptosis and aggravates white matter lesions.

Recent evidence suggests that ferroptosis plays a crucial role in the occurrence and development of white matter lesions. However, the mechanisms and regulatory pathways involved in ferroptosis within white matter lesions remain unclear. Long non-coding RNAs (lncRNAs) have been shown to influence the occurrence and development of these lesions.

Regenerable Molecularly Imprinted Polymer Biosensor for Electrochemical Detection of Nonelectroactive Branched-Chain Amino Acids in Human Sweat.

The significant challenge in achieving regeneration for conventional molecularly imprinted polymers (MIPs) restricts their promising application in continuous monitoring of biochemical molecules closely related to human health, especially nonelectroactive molecules. This is because they are either limited to a single use or require removal of imprinted templates through chemical washing steps, which is clearly impractical for sustainable monitoring. Here, a class of regenerable MIP biosensors, taking nonelectroactive branched-chain amino acids (BCAAs) as templates and methyldopa as a functional monomer, was engineered to achieve repeatable regeneration and target recognition.

A multi-scene deep learning model for automated segmentation of acute vertebral compression fractures from radiographs: a multicenter cohort study.

Objective: To develop a multi-scene model that can automatically segment acute vertebral compression fractures (VCFs) from spine radiographs.

Methods: In this multicenter study, we collected radiographs from five hospitals (Hospitals A-E) between November 2016 and October 2019. The study included participants with acute VCFs, as well as healthy controls.

Afatinib Combined with Bevacizumab in the Treatment of Patients with Non-Small Cell Lung Cancer Harboring EGFR G719X, S768I or L861Q/P Mutations.

Purpose: To investigate the efficiency and safety of afatinib in combination with bevacizumab in patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) G719X, S768I, and L861Q mutations.

Patients And Methods: We retrospective studied treatment naïve patients with local advanced or metastatic non-small cell lung cancer harboring EGFR G719X, S768I, and L861Q mutations from January 2017 to August 2021. EGFR tyrosine kinase inhibitors (TKIs) were the first-line treatment in all patients.

Finite element analysis of additive manufactured porous peek artificial vertebral bodies in lumbar total en bloc spondylectomy.

Background: Lumbar total en bloc spondylectomy and internal fixation allows the removal of spinal tumors and the reconstruction of spinal stability. However, postoperative internal fixation failure due to unmatched spinal biomechanics remains obscure.

Purpose: This study aimed to assess the biomechanical characteristics of additive manufactured (AM) porous polyetheretherketone (PEEK) artificial vertebral body for total en bloc spondylectomy and internal fixation.

Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer.

Cellular senescence is a response to various stress signals, which is characterized by stable cell cycle arrest, alterations in cellular morphology, metabolic reprogramming and production of senescence-associated secretory phenotype (SASP). When it occurs in the immune system, it is called immunosenescence. Cervical cancer is a common gynecological malignancy, and cervical cancer screening is generally recommended before the age of 65.

Detailed Analysis of the Palmomental Reflex and Its Clinical Significance.

Purpose: This comprehensive review thoroughly explores the clinical significance of the palmomental reflex (PMR) in neurological disorders. PMR is a primitive reflex that, when reemerging in adults, indicates underlying neurological dysfunction.

Method: The article elaborates on the clinical assessment techniques, neurophysiological basis, and applications of PMR in various neurological disorders, including neurodegenerative diseases, cerebrovascular disorders, traumatic brain injury, and multiple sclerosis.

Oncologic Outcomes and Safety Assessment of Retroperitoneal Laparoscopic Partial Nephrectomy versus Open Partial Nephrectomy in Treating Patients with Localized Renal Cell Carcinoma: A Propensity Score Matching Study.

Aim: Surgical intervention is crucial in radical resection of renal cell carcinoma (RCC). Different surgical procedures have different oncologic outcomes and safety in patients with RCC. Therefore, we aimed to investigate the oncologic outcomes and safety of retroperitoneal laparoscopic partial nephrectomy (RLPN) versus open partial nephrectomy (OPN) in treating patients with localized RCC.

Host-dependent C-to-U RNA editing in SARS-CoV-2 creates novel viral genes with optimized expressibility.

Rampant C-to-U RNA editing drives the mutation and evolution of SARS-CoV-2. While much attention has been paid to missense mutations, the C-to-U events leading to AUG and thus creating novel ORFs were uninvestigated. By utilizing the public time-course mutation data from the worldwide SARS-CoV-2 population, we systematically identified the "AUG-gain mutations" caused by C-to-U RNA editing.

Establishment of the Prognostic Signature with Genes Related to G2/M Checkpoint in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality in the world. Prognostic indicators such as clinicopathological characteristics and single molecular signature are far from satisfactory in clinical practice. More and more researches have suggested that polygenic prognostic features could predict the prognosis of cancer more precisely than single genes nowadays.

Synergistic Coordination Effect and Metal-Support Interaction Engineering of Single-Atom Mn-N Sites for Boosting Sensitive and Selective Dopamine Biosensing in Human Serum.

Coordination environment of metal atoms is core for designing high-performance single-atom catalysts (SACs), while metal-support interaction also has an important effect on structure-function relationship. Nevertheless, the interaction effect of metal-support is mostly ignored. Through synergistic regulation of coordination environment and metal-support interaction, Mn SAC with atom-dispersed Mn-N sites on dopamine (DA) support is synthesized for sensitive and selective DA oxidation based on theoretical calculations and experimental explorations.

N-Terminal Capping of the αO-Conotoxin Analogue GeX-2 Improves the Serum Stability and Selectivity toward the Human α9α10 Nicotinic Acetylcholine Receptor.

α9α10 nicotinic acetylcholine receptors (nAChRs) are a promising nonopioid analgesic target, with α9α10 nAChR antagonists showing efficacy against chemotherapy-induced hyperalgesia and allodynia. GeX-2, a potent analgesic conotoxin antagonist of α9α10 nAChRs, has limited serum stability. This study improved GeX-2 stability by capping its N-terminal with fatty acids or polyethylene glycol chains, which enhanced its serum stability but eliminated activity at G protein-coupled γ-aminobutyric acid type B (GABA) receptor-coupled Ca2.

Microbial strategies for effective microplastics biodegradation: Insights and innovations in environmental remediation.

Microplastics (MPs), diminutive yet ubiquitous fragments arising from the degradation of plastic waste, pervade environmental matrices, posing substantial risks to ecological systems and trophic dynamics. This review meticulously examines the origins, distribution, and biological impacts of MPs, with an incisive focus on elucidating the molecular and cellular mechanisms underpinning their toxicity. We highlight the indispensable role of microbial consortia and enzymatic pathways in the oxidative degradation of MPs, offering insights into enhanced biodegradation processes facilitated by innovative pretreatment methodologies.