Reporting completeness and methodological quality of guidelines for nutritional care of critically ill patients: A meta-research utilizing Reporting Items for practice Guidelines in HealTh Care (RIGHT) and Appraisal of Guidelines for Research & Evaluation (AGREE II).

Studies have demonstrated that the quality and transparency of reporting Clinical Practice Guidelines (CPGs) in healthcare are low. This meta-research aimed to evaluate the adherence of nutrition CPGs for critically ill adults to the reporting RIGHT checklist and its association with the methodological quality assessed by AGREE II, along with other potential publication-related factors. A systematic search for CPGs until December 2024 was conducted.

Trace amine signaling in zebrafish models: CNS pharmacology, behavioral regulation and translational relevance.

Tyramine, β-phenylethylamine, octopamine and other trace amines are endogenous substances recently recognized as important novel neurotransmitters in the brain. Trace amines act via multiple selective trace amine-associated receptors (TAARs) of the G protein-coupled receptor family. TAARs are expressed in various brain regions and modulate neurotransmission, neuronal excitability, adult neurogenesis, cognition, mood, locomotor activity and olfaction.

Retained versus removed copper intrauterine device during pregnancy: An updated systematic review and meta-analysis.

Introduction: Intrauterine devices (IUDs) are highly effective contraceptives. Despite their effectiveness, pregnancies can occur during IUD use, and the management of such cases, particularly when the pregnancy is desired, remains controversial.

Material And Methods: We conducted a systematic review and meta-analysis to evaluate outcomes in women who unintentionally conceived while using IUDs and chose to continue their pregnancies.

Comparison of the diagnostic performance of non-contrast MR angiography and planar V/Q scintigraphy for pulmonary embolism: a systematic review and meta-analysis.

Objectives: To conduct a meta-analysis of the diagnostic performance of non-contrast magnetic resonance pulmonary angiography (NC-MRPA) and ventilation-perfusion (V/Q) scintigraphy for the detection of acute pulmonary embolism (PE).

Materials And Methods: Systematic searches of electronic databases were conducted from 2000 to 2024. Primary outcomes were per-patient sensitivity and specificity of NC-MRPA and V/Q scintigraphy.

Mitochondria as a Therapeutic Target: Focusing on Traumatic Brain Injury.

Mitochondria are organelles of eukaryotic cells delimited by two membranes and cristae that consume oxygen to produce adenosine triphosphate (ATP), and are involved in the synthesis of vital metabolites, calcium homeostasis, and cell death mechanisms. Strikingly, normal mitochondria function as an integration center between multiple conditions that determine neural cell homeostasis, whereas lesions that lead to mitochondrial dysfunction can desynchronize cellular functions, thus contributing to the pathophysiology of traumatic brain injury (TBI). In addition, TBI leads to impaired coupling of the mitochondrial electron transport system with oxidative phosphorylation that provides most of the energy needed to maintain vital functions, ionic homeostasis, and membrane potentials.

Understanding the Utilization of Wasted Bread as a Brewing Adjunct for Producing a Sustainable Wheat Craft Beer.

Wasted bread (WB) has been studied as an alternative ingredient for increasing the sustainable footprint in the beer production chain. There are gaps in the literature on the impact of WB on beer manufacturing. Thus, the objective was to evaluate the addition of WB as a replacement for wheat flakes in a craft beer.

Factors Associated with HIV Risk Perception Among Cisgender Female Sex Workers in Brazil.

This study evaluated the association between HIV risk perception and sociodemographic and behavioral characteristics among cisgender female sex workers in the five regions of Brazil. A cross-sectional, multicenter study using respondent-driven sampling was used. Sex workers over 18 years of age and who reported commercial sex in the past four months were included.

Sacubitril-Valsartan in Cancer Therapy-Induced Heart Failure: A Systematic Review and Meta-Analysis of Functional and Hemodynamic Parameters.

Background: Cancer therapy-induced cardiotoxicity (CTRCD), in the form of heart failure with reduced ejection fraction (HFrEF), is being increasingly recognized. However, the potential benefits of sacubitril/valsartan (S/V) in managing HFrEF secondary to CTRCD remain unclear.

Objective: We performed a systematic review and meta-analysis to assess the effectiveness of S/V in preventing cardiotoxicity.

Using Zebrafish Models to Study Epitranscriptomic Regulation of CNS Functions.

Epitranscriptomic regulation of cell functions involves multiple post-transcriptional chemical modifications of coding and non-coding RNA that are increasingly recognized in studying human brain disorders. Although rodent models are presently widely used in neuroepitranscriptomic research, the zebrafish (Danio rerio) has emerged as a useful and promising alternative model species. Mounting evidence supports the importance of RNA modifications in zebrafish CNS function, providing additional insights into epitranscriptomic mechanisms underlying a wide range of brain disorders.

Mismatch negativity in children with developmental Dyslexia.

Objective: To describe and compare the latencies and amplitudes of Mismatch Negativity between children with and without Developmental Dyslexia.

Methods: Cross-sectional and comparative study, consisting of a study group of 52 children with Developmental Dyslexia and a control group of 52 children with typical development, matched by age and sex, aged between 9 years and 11 years and 11 months of both sexes. All participants underwent Otoscopy, Acoustic Immittance Measurements, Pure Tone Audiometry, Speech Audiometry, Brainstem Auditory Evoked Potential and Mismatch Negativity.

Differential effects of chronic unpredictable stress on behavioral and molecular (cortisol and microglia-related neurotranscriptomic) responses in adult leopard (leo) zebrafish.

Stress plays a key role in mental, neurological, endocrine, and immune disorders. The zebrafish (Danio rerio) is rapidly gaining popularity as s model organism in stress physiology and neuroscience research. Although the leopard (leo) fish are a common outbred zebrafish strain, their behavioral phenotypes and stress responses remain poorly characterized.

Laser-Induced Olfactory Bulbectomy in Adult Zebrafish as a Novel Putative Model for Affective Syndrome: A Research Tribute to Brian Leonard.

Inducing multiple neurobehavioural and neurochemical deficits, olfactory bulbectomy (OBX) has been developed as a rodent model of depression with potential for antidepressant drug screening. However, the generality of this model in other vertebrate taxa remains poorly understood. A small freshwater teleost fish, the zebrafish (Danio rerio), is rapidly becoming a common model species in neuroscience research.

Analysis of delayed cerebral ischemia incidence after treatment for aneurysmal subarachnoid hemorrhage in young adults: A cohort study.

Background: This study aimed to analyze the incidence of delayed cerebral ischemia (DCI) and outcome stratified by age in patients who suffered aneurysmal subarachnoid hemorrhage.

Methods: A cohort study with patients from Christ the Redeemer Hospital from 2014 to 2020, with 359 patients separated into 2 groups, 48 of them aged under 40 years and 311 aged 40 years or over.

Results: In patients under 40 years of age, DCI was found in 81.

Association between healthy dietary pattern and common mental disorders in women: a cross-sectional population-based study.

Objectives: Scientific evidence suggests an association between diet quality and the prevalence of common mental disorders (CMD) in women. Thus, this study aimed to investigate the association between a healthy dietary pattern and CMD among women.

Methods: A cross-sectional population-based study was conducted on a representative sample of 1128 women, aged 20-69 years, residing in the urban area of São Leopoldo, RS, Brazil.

Nutritional Counseling Based on Mindful Eating for the Eating Behavior of People Living with Overweight and Obesity: A Randomized Clinical Trial.

Objectives: This study aimed to evaluate the effect of a counseling approach based on Mindful Eating on the eating behavior of individuals living with overweight and obesity.

Methods: A 16-week randomized clinical trial was conducted to compare an online group intervention (IG) with individual online nutritional counseling (TAU). Volunteers ( = 61), aged 18 or older with BMI ≥ 25 kg/m, were randomly assigned to the two groups and invited to participate in eight biweekly sessions.

Adenosinergic Signalling in Cervical Cancer Microenvironment.

Despite the emergence of the first human papillomavirus vaccine, the incidence of cervical cancer is still responsible for more than 350,000 deaths yearly. Over the past decade, ecto-5'-nucleotidase (CD73/5'-NT) and extracellular adenosine (ADO) signalling has been the subject of many investigations to target cancer progression. In general, the adenosinergic axis has been linked to tumourigenic effects.

Nasopharyngeal carriage of Streptococcus pneumoniae among Brazilian children: Interplay with viral co-infection.

Nasopharyngeal transmission of Streptococcus pneumoniae is a prerequisite for the development of pneumococcal diseases. Previous studies have reported a relationship between respiratory viruses and S. pneumoniae infections.

Quality indicators for urine sample contamination: can squamous epithelial cells and bacteria count be used to identify properly collected samples?

Objectives: To evaluate urinalysis parameters useful for identifying mixed cultures in urine culture using an automated urinary particle analyzer to assess quality indicators (QIs) for urine sample contamination.

Methods: A retrospective observational cross-sectional study was conducted with 2,527 urine samples from patients of a quaternary hospital in Brazil. Urine samples were processed simultaneously in Sysmex UF-5000 flow cytometry analyzer (urinalysis) and MALDI-TOF (culture).

Bovine bone-based activated carbon composite containing nanomagnetite as a catalyst for photo-Fenton reactions.

Magnetic composites (MC) prepared from magnetite nanoparticles (MNP) and activated carbon from bovine bone (AC) in different proportions (75/25, 50/50, and 25/75) were used as catalysts in the photo-Fenton process to degrade methylene blue (MB) in aqueous solution. The materials were prepared by the citrate-nitrate sol-gel synthesis method and used as catalysts in the photo-Fenton process. The photocatalytic tests were performed in a cylindrical reactor with a 4.

Comparing pulsed field ablation with very high-power and high-power short-duration radiofrequency ablation for atrial fibrillation: a systematic review and meta-analysis.

Background: Catheter ablation is a key treatment for atrial fibrillation (AF), with high-power, very high-power short-duration and pulsed field ablation (PFA) being efficient options. However, direct comparisons between these techniques are lacking.

Objective: We performed a systematic review and meta-analysis, which included predominantly observational studies (four retrospective and one prospective study), to compare PFA and High-power short-duration (HPSD) and very high-power short-duration (vHPSD) radiofrequency (RF) ablation in patients with AF.

Correction: Sebro et al. Implementation of Antigen-Based Diagnostic Assays for Detection of Histoplasmosis and Cryptococcosis among Patients with Advanced HIV in Trinidad and Tobago: A Cross-Sectional Study. 2024, , 695.

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Design for People With Dementia: A Scoping Review on the Perspective of Inclusion, Accessibility, and Equity in Healthcare.

We explored the literature on the use of design in dementia care and the relationships with inclusion, accessibility, and equity in the past decade. A body of research indicates the importance of studies that focus on a person-centered approach, with a direct potential to impact the quality of life of people with dementia through inclusion, accessibility, and equity. Although there is a growing presence of the literature on design approaches in dementia care settings, there is a need to integrate these findings for a better understanding of the progress in this field.

Barriers and facilitators for preventing mother-to-child transmission of Trypanosoma cruzi and hepatitis B in the Gran Chaco region: a qualitative analysis using the consolidated framework for implementation research (CFIR).

Background: Mother-to-child transmission (MTCT) of Trypanosoma cruzi and hepatitis B virus (HBV) increases morbidity and disability in Latin America and the Caribbean. The tailormade comprehensive antenatal care based on the Framework for the elimination of MTCT of HIV, syphilis, hepatitis B virus (HBV), and Chagas disease (EMTCT Plus) has been implemented in the region since 2018 through a private-public partnership. This study aimed to estimate the effectiveness of the intervention in preparing MTCT of T.

Assessment of residual gastric volume by ultrasound prior to upper endoscopy: a prospective cohort study.

Purpose: Pulmonary aspiration is an adverse event with high morbidity and mortality. Despite fasting for > 8 hr, some patients still have residual gastric volume and are thus at risk of aspiration. We aimed to determine the accuracy of gastric ultrasound in assessing residual gastric content in patients undergoing upper gastrointestinal endoscopy.

Association of Body Image Perception / (Dis)Satisfaction and Symptoms of Eating Disorders in University Students of Health Sciences.

We aimed to investigate the association of body image perception / (dis)satisfaction with eating disorders symptoms. We conducted a cross-sectional university-based study with 534 students, aged 18 years or older, from a federal higher education institution specializing in health sciences and located in Southern Brazil in 2023. We evaluated eating disorder symptoms using the Brazilian version of the SCOFF screening tool (≥2 symptoms) and body image using a silhouette scale developed for Brazilian adults.