497 results match your criteria: "University of Health Sciences Bursa Yüksek Ihtisas Training and Research Hospital[Affiliation]"

A new implementation that facilitates bleeding control in thoracic surgery: tamponing with tranexamic acid.

Indian J Thorac Cardiovasc Surg

January 2025

Department of Thoracic Surgery, Faculty of Medicine, Uludağ University, Bursa, Turkey.

Unlabelled: Bleeding control is one of the most vexing complications in the thoracic surgery. Tranexamic acid is the most used antifibrinolytic nowadays. We present a new implementation which can easily and effectively control the pulmonary artery branch bleeding during lung resection.

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Background: Malnutrition is a critical clinical condition that requires early intervention due to its potential for causing preventable fatalities and complications. This study aims to assess the impact of outpatient enteral nutrition support (ENS) as a therapeutic intervention on anthropometric measurements, intolerance, and micronutrient values in malnourished children.

Methods: This observational study included 344 patients in ages 1 to 18 treated with standard enteral nutrition (1.

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Objectives: To evaluate the predictivity of haematologic parameters and HALP score on testicular viability in adults with testicular torsion.

Methods: We retrospectively analyzed the clinical data of 139 men ≥18 years of age who underwent testicular detorsion with fixation (n = 90) or orchiectomy (n = 49) due to testicular torsion in five different tertiary centers between May 2019 and August 2023. Demographic, pre-, peri- and postoperative data were analyzed.

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Since the first successful use of cardiopulmonary bypass (CPB), much has changed in its technology, area of use, and management. Despite suggestions in guidelines, the institutional behavior may change based on institutional experience and established habits. This so-called "deviation" may alter management strategies in favorable or unfavorable ways.

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Transient neurologic dysfunction after aortic arch surgery.

Gen Thorac Cardiovasc Surg

December 2024

Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Mimar Sinan Town, Emniyet Street, Yıldırım, Bursa, 16310, Turkey.

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Background: Hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) affect left ventricular hemodynamics. This study compared the effect of two treatment modalities, CAPD and HD, on left ventricular systolic and diastolic functions in maintenance dialysis patients.

Methods: A total of 47 patients (24 CAPD and 23 HD) undergoing long-term dialysis were included in the study.

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Objective: This study aimed to conduct a unified analysis comparing the clinical characteristics, disease progression, and treatment responses of pediatric-onset multiple sclerosis (POMS), adult-onset multiple sclerosis (AOMS), and late-onset multiple sclerosis (LOMS) patients.

Methods: Utilizing a retrospective cohort design, we analyzed the records of 269 patients from MS clinics and categorized them into the POMS (<18 years), AOMS (≥18 and <50 years), and LOMS (≥50 years) groups based on age at diagnosis. Data collection focused on demographics, clinical manifestations, disability scores, MRI findings, and treatment outcomes.

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Objectives: Congenital syphilis can cause severe morbidities such as hydrops fetalis, preterm birth, low birth weight, hepatosplenomegaly, pneumonia, hypoglycemia, etc., and mortality. Despite hypoglycemia being reported in congenital syphilis and hyperinsulinism, only one case was described.

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: The optimal choice of cardioplegia solution in minimally invasive cardiac surgeries (MICS) remains debated, as prolonged myocardial protection is essential to avoid interruptions to the surgical flow, which can prolong aortic cross-clamp time and cardiopulmonary bypass time, especially in the constrained surgical field. We conducted a network meta-analysis to evaluate the safety and efficacy of the del Nido (DN), histidine-tryptophan-ketoglutarate (HTK), blood cardioplegia (BC), and St. Thomas' (STH) solutions in MICS.

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Article Synopsis
  • Previous studies on the use of serial prolactin (PRL) measurements for diagnosing mild hyperprolactinemia (HP) have shown mixed results, prompting this study to explore their effectiveness alongside a new method called the prolactin decrease rate (PDR).
  • Analysis of medical records from 221 patients showed that 153 had mild HP and demonstrated that serial PRL measurements were less effective at detecting HP compared to single measurements, while the PDR provided additional specificity for diagnosis.
  • The study concluded that combining serial PRL measurements with the PDR is a more reliable approach for diagnosing prolactinoma and HP when clinical symptoms are unclear.
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New biological markers in diagnosis and follow-up of brucellosis cases.

Diagn Microbiol Infect Dis

February 2025

Department of Immunology, Bursa Uludag University Faculty of Medicine, Bursa, Turkey. Electronic address:

Brucellosis remains a significant public health issue in some parts of the world. It is clear that new laboratory methods are needed to diagnose brucellosis. Currently, no test method meets the criteria of high specificity, sensitivity, reliability, and low cost for the diagnosis of brucellosis, which could also predict chronicity.

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Article Synopsis
  • This study focuses on improving the diagnostic accuracy of MRI in identifying prostate cancer lesions before biopsies, aiming to understand independent risk factors influencing biopsy results.
  • An analysis of 364 patients showed that while certain MRI parameters (like PI-RADS scores and ADC values) are helpful in distinguishing cancer from benign conditions, they do not effectively predict clinically significant prostate cancer.
  • The only strong predictor for clinically significant prostate cancer was the total prostate-specific antigen (PSA) level, indicating its importance in the diagnostic process.
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: Secukinumab is a monoclonal antibody against interleukin 17 approved for patients with axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), and psoriasis. Treating axSpA and PsA patients with a history of malignancy is a challenge. While initial results on the applicability of secukinumab in this patient group are positive, the number of studies on this topic remains limited.

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Aim: This study aims to evaluate the reliability and validity of the Turkish version of the Standard Assessment of Global Everyday Activities (SAGEA) scale in older adults.

Methods: The study employed a cross-sectional, methodological design. The SAGEA scale was administered twice, with a two-week interval for test-retest reliability.

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Atrial fibrillation in elderly patients with severe aortic stenosis.

Kardiol Pol

October 2024

University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Department of Cardiovascular Surgery, Mimar Sinan Town. Emniyet Street. Yıldırım/BURSA, Turkey.

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Background: Ocrelizumab (OCR) effectively modifies the disease course in multiple sclerosis (MS) patients but may cause a preinfusion "wearing-off phenomenon" (WoP). This study explored the prevalence, timing, and severity of this phenomenon in MS patients using the OCR, as well as the associated symptoms and treatment satisfaction.

Methods: We conducted a prospective multicenter study across 11 MS centers involving MS patients aged 18-70 years who had received at least two OCR doses.

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: Metabolic dysfunction-associated steatotic liver disease (MASLD) and polycystic ovary syndrome (PCOS) share several pathophysiological mechanisms. While the prevalence of MASLD has been extensively studied in PCOS populations, the occurrence of PCOS among female adolescents with transient elastography (TE)-confirmed MASLD in pediatric hepatology settings remains poorly characterized. This cross-sectional study aims to address this knowledge gap and elucidate potential clinical and biochemical differences between female adolescents with MASLD and comorbid PCOS compared to those without PCOS.

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Article Synopsis
  • The study evaluated the effects of laser therapy combined with splints and exercise on patients with cubital tunnel syndrome (CuTS) compared to a placebo treatment.
  • A total of 64 patients were randomly divided into two groups, one receiving actual laser therapy and the other receiving sham laser therapy, alongside standardized treatments like splints and exercises.
  • Results showed significant short-term improvements in pain and function for the laser therapy group compared to the placebo, but both groups had similar medium-term effects, suggesting the need for more research with larger sample sizes.
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  • * Among 106 patients, 83 had CN, and those who had the surgery could continue their nivolumab treatment for longer (14.5 months) compared to those who didn't have the surgery (6.7 months).
  • * Overall survival was better for patients with CN (22.9 months) compared to those without it (8.1 months), but the surgery and certain medical scores were important factors for how long they lived.
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Erectile dysfunction (ED) is one of the most common complaints in the male sexual health field, with a multifactorial etiology yet to be fully elucidated. Nucleobindin 2 (NUCB2)/nesfatin-1, known for its regulatory role in food intake, can also regulate the vascular, neural and hormonal systems, all of which are of great importance in the etiology of ED. The present study included 43 men with ED and 40 healthy individuals without ED.

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Article Synopsis
  • * A study in Turkey examined the responses of 17 patients with solid tumors and NTRK fusions who received entrectinib, revealing a median age of 42 years and various types of cancer, with NTRK1 and NTRK3 being the most common gene rearrangements.
  • * Results showed a 35.3% objective response rate with side effects leading to dosage reductions in four patients; the median overall survival was 20.8 months
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