Effectiveness of early pharmaceutical interventions in symptomatic COVID-19 patients: A randomized clinical trial.

Objective: We assessed the effectiveness of oral Hydroxychloroquine (HC), Azithromycin (AZ) and Oseltamivir (OS), alone or combined, among patients hospitalized with mildly symptomatic coronavirus infectious disease (COVID-19).

Methods: Following the approval of the National Bioethics Committee and prospective registration (clinicaltrials.gov NCT04338698), a multicenter randomized clinical trial of adaptive design was conducted at 10 multispecialty hospitals in Pakistan.

Effectiveness of basic training session regarding the awareness of Ebola virus disease among nurses of public tertiary care hospitals of Lahore.

Objective: To evaluate the effectiveness of basic training session regarding the awareness of ebola virus disease among nurses of public tertiary care hospitals.

Methods: The quasi-experimental study was conducted in Lahore, Pakistan, from November to December 2015, and comprised nurses working at three public tertiary care hospitals. Baseline and post intervention data was collected through a questionnaire, and was compared using SPSS 20 .

Mutations of the human interferon alpha-2b (hIFNα-2b) gene in cancer patients receiving radiotherapy.

This research aimed to find out the impact of ionizing radiations on the hIFNα-2b gene of radiotherapy treated cancer patients. The gene hIFNα-2b synthesizes a protein which is an important anticancerous and antiviral protein. The cancer patients (breast, lung, thyroid, oral and prostate) who were undergoing a radiotherapy treatment were selected.

Mutations of the human interferon alpha-2b gene in brain tumor patients exposed to different environmental conditions.

This study was aimed at finding out mutations of an anticancerous, antiviral and immunomodulatory gene (human interferon alpha-2b) in low- and high-grade brain tumor patients and correlate from hematological profiles. A molecular analysis was performed in which DNAs were extracted from brain biopsy samples of brain tumor patients. The gene was amplified through the PCR technique, and genetic data from sequencing were analyzed by bioinformatics to determine how mutations will lead to changes in human interferon alpha 2b protein in patients.