7 results match your criteria: "University of Health Science Izmir Bozyaka Training and Research Hospital[Affiliation]"
Evaluation of the effects of regulatory T cells on survival outcomes in patients with acute leukemia who developed febrile neutropenia.
J Int Med Res
March 2025
Infectious Diseases and Clinical Microbiology Clinic, University of Health Science Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
ObjectivesAcute leukemia often leads to severe complications such as febrile neutropenia. Mortality rates remain high, underscoring the need for novel prognostic markers. Regulatory T cells (Tregs) have not been extensively studied in this context.
View Article and Find Full Text PDFBloodstream Infections Presenting with Septic Shock in Neutropenic Cancer Patients: Impact of Empirical Antibiotic Therapy.
Microorganisms
March 2024
Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, 08907 Barcelona, Spain.
Article Synopsis
- - The study analyzed 1,213 cases of blood-stream infections in onco-hematological neutropenic patients, finding that 33% experienced septic shock, with factors like solid tumors, high-risk MASCC index, pneumonia, and multidrug-resistant infections significantly more common among these patients.
- - Patients with septic shock were more likely to receive inadequate antibiotic therapy and had worse outcomes, including a high need for ICU support, mechanical ventilation, and increased mortality rates at 7 and 30 days.
- - Key risk factors for death included need for intubation and inadequate antibiotic therapy, while treatments with granulate colony-stimulating factor and urinary tract infections were linked to better survival, highlighting the need for individualized care strategies for these
Bloodstream Infections in Patients with Cancer: Differences between Patients with Hematological Malignancies and Solid Tumors.
Pathogens
September 2022
Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, 08907 Barcelona, Spain.
Objectives: To assess the clinical features and outcomes of Pseudomonas aeruginosa bloodstream infection (PA BSI) in neutropenic patients with hematological malignancies (HM) and with solid tumors (ST), and identify the risk factors for 30-day mortality. Methods: We performed a large multicenter, retrospective cohort study including onco-hematological neutropenic patients with PA BSI conducted across 34 centers in 12 countries (January 2006−May 2018). Episodes occurring in hematologic patients were compared to those developing in patients with ST.
View Article and Find Full Text PDFEffect of Combination Antibiotic Empirical Therapy on Mortality in Neutropenic Cancer Patients with Pneumonia.
Microorganisms
March 2022
Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, 08907 Barcelona, Spain.
To assess the effect of combination antibiotic empirical therapy on 30-day case-fatality rate in neutropenic cancer patients with Pseudomonas aeruginosa (PA) bacteremic pneumonia. This was a multinational, retrospective cohort study of neutropenic onco-hematological patients with PA bloodstream infection (BSI) (2006−2018). The effect of appropriate empirical combination therapy, appropriate monotherapy and inappropriate empirical antibiotic therapy [IEAT] on 30-day case-fatality was assessed only in patients with PA bacteremic pneumonia.
View Article and Find Full Text PDFPretransplant Consolidation Therapies Improve the Outcome of Myeloablative Allogeneic Transplantation in Adults with Ph-negative Acute Lymphoblastic Leukemia.
Clin Lymphoma Myeloma Leuk
August 2022
Ankara University School of Medicine, Department of Hematology, Ankara, Turkey.
Backround And Aim: The benefit of pre-transplant consolidation in patients with acute lymphoblastic leukemia (ALL) who achieved first complete remission (CR1) has not yet been clearly demonstrated. Here, we aimed to investigate the relationship between the treatments received before transplantation and transplant outcome in Ph-ALL patients who underwent myeloablative allo-HSCT in CR1.
Patients And Methods: A total of 55, 32 (58.
Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa.
Antimicrob Agents Chemother
March 2020
Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Barcelona, Spain
We aimed to assess the rate and predictive factors of bloodstream infection (BSI) due to multidrug-resistant (MDR) in neutropenic cancer patients. We performed a multicenter, retrospective cohort study including oncohematological neutropenic patients with BSI due to conducted across 34 centers in 12 countries from January 2006 to May 2018. A mixed logistic regression model was used to estimate a model to predict the multidrug resistance of the causative pathogens.
View Article and Find Full Text PDFImpact of antibiotic resistance on outcomes of neutropenic cancer patients with bacteraemia (IRONIC study): study protocol of a retrospective multicentre international study.
BMJ Open
May 2019
Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain.
Article Synopsis
- The study focuses on the increasing issue of multidrug-resistant Pseudomonas aeruginosa (MDRPA) in neutropenic cancer patients, which can lead to severe sepsis and higher mortality rates.
- The research involves a retrospective review of PA bacteraemia cases from multiple international centers over a 12-year period, aiming to determine the impact of antibiotic resistance and identify risk factors associated with mortality.
- Ethical considerations include patient privacy protections, with personal data anonymized in compliance with relevant data protection laws, and findings will be shared in academic conferences and publications.