An ion-paired moxifloxacin nanosuspension eye drop provides improved prevention and treatment of ocular infection.

There are numerous barriers to achieving effective intraocular drug administration, including the mucus layer protecting the ocular surface. For this reason, antibiotic eye drops must be used multiple times per day to prevent and treat ocular infections. Frequent eye drop use is inconvenient for patients, and lack of adherence to prescribed dosing regimens limits treatment efficacy and contributes to antibiotic resistance.

Analysis of COVID-19 and comorbidity co-infection model with optimal control.

In this work, we develop and analyze a mathematical model for the dynamics of COVID-19 with re-infection in order to assess the impact of prior comorbidity (specifically, ) on COVID-19 complications. The model is simulated using data relevant to the dynamics of the diseases in Lagos, Nigeria, making predictions for the attainment of peak periods in the presence or absence of comorbidity. The model is shown to undergo the phenomenon of backward bifurcation caused by the parameter accounting for increased susceptibility to COVID-19 infection by comorbid susceptibles as well as the rate of reinfection by those who have recovered from a previous COVID-19 infection.

A new species of rake-legged mite, (Prostigmata, Caeculidae), from Canada and a systematic analysis of its genus.

The genus Dufour (Prostigmata, Caeculidae) contains 19 previously described species, most of which are found in North America, and for which no comprehensive phylogenetic treatment exists. Here, one new species from Alberta, Canada, is described: Bernard & Lumley, , and another caeculid known to be present in Canada is documented. The new species is characterized within the genus with a character state matrix, from which an updated key is produced.

The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project.

The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.

Development of a modified Margaria-Kalamen anaerobic power test for American football athletes.

This study examined a modification of the Margaria-Kalamen test for football players. The football stair climb test (FST) protocol used in this study increased the vertical displacement (20 steps, 3.12 m) so that the mean best time for the test was 2.

Separation of benzodiazepines on a new carbohydrate-based chiral stationary phase for HPLC.

Several benzodiazepines were enantioresolved on a new carbohydrate chiral stationary phase based on maltooligosaccharides. The role of organic modifier, ionic strength, pH and temperature are examined and the results are discussed. In general, selectivity and retention were found to decrease with increasing organic modifier concentration.