573 results match your criteria: "University of Hawaii John A. Burns School of Medicine.[Affiliation]"

Purpose The purpose of this study is to compare patient-reported outcomes of minimally invasive treatments for lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH), namely, transurethral water vapor therapy (Rezum) and prostatic urethral lift (UroLift), due to the lack of direct comparison in the existing literature. Methods A retrospective single-institution study was conducted comparing Rezum and UroLift procedures performed by three surgeons between January 2019 and June 2022. The difference in American Urological Association Symptom Scores (AUA SS) was the primary outcome measure.

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  • - The study investigates attention problems in children born preterm (<30 weeks gestation) from ages 2 to 5, analyzing factors that influence these attention trajectories and their relationship to ADHD diagnoses.
  • - Using data from 608 infants in a large prospective study, researchers found that while most children displayed low initial attention problems, there were notable individual differences in symptom progression over time.
  • - The findings indicate that children with higher initial attention issues and faster increases in symptoms are at a greater risk for an ADHD diagnosis, highlighting the need for tailored interventions based on individual characteristics.
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  • Yolk sac tumor (YST) is typically seen in children but can metastasize to the spine in rare adult cases, particularly affecting the lower cervical and upper thoracic vertebrae.
  • A 28-year-old male with a history of YST experienced severe neurological symptoms due to metastasis, which was confirmed by imaging and treated with surgery, but he ultimately faced disease recurrence.
  • While YST metastasis is uncommon, its occurrence to the cervical and thoracic regions requires an individualized treatment approach, including potential surgery, chemotherapy, and radiation, for better patient outcomes.
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  • This study focuses on identifying different immune profiles in sepsis patients based on their body temperature patterns to potentially enable more targeted treatments.
  • Researchers categorized 3,576 hospitalized patients with suspected infections into four distinct temperature trajectory subphenotypes and assessed their clinical outcomes and biomarker levels.
  • Findings revealed significant differences in mortality rates among these subphenotypes, with the highest mortality in hypothermic patients and notable differences in 20 specific biomarkers across the temperature groups, highlighting the complexity of sepsis.
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Background: Recent studies have demonstrated an obesity paradox, where obese patients with cardiovascular disease have a better outcome compared to those with normal weight. However, the effect of obesity and body mass index (BMI) on the outcome of patients with cardiac resynchronization therapy (CRT) devices remains unclear. The current study aims to investigate this relationship using all available published data.

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  • The study aimed to explore the relationship between weather variables and various pathogens linked to infectious conjunctivitis globally.
  • Researchers analyzed data from 498 cases across 8 countries, correlating pathogen types with weather data, particularly looking at temperature, precipitation, and humidity.
  • Findings indicated that higher humidity and precipitation increased the likelihood of RNA virus and fungal infections while decreasing the odds of DNA virus and bacterial infections, highlighting the complex influence of weather on conjunctivitis-related pathogens.
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Epigenetic associations with neonatal age in infants born very preterm, particularly among genes involved in neurodevelopment.

Sci Rep

August 2024

Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA, 30322, USA.

Article Synopsis
  • * A study analyzed DNA methylation patterns in buccal cells from VPT infants to see how their gestational age (GA) and age since conception (post-menstrual age, PMA) affect their development.
  • * Researchers found thousands of DNA sites linked to GA and PMA, with pathways related to brain development and growth significantly affected, indicating that early life epigenetic changes are vital for neurodevelopment in preterm infants.
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Evaluation and Management of Thyrotoxicosis During Pregnancy.

Endocrinol Metab Clin North Am

September 2024

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, USA; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard (111D), Los Angeles, CA 90073, USA. Electronic address:

This review summarizes the diagnosis and management of thyrotoxicosis in pregnancy. The diagnostic clinical and biochemical considerations used to distinguish the various etiologies of hyperthyroidism from appropriate physiologic changes during pregnancy will be outlined. Finally, the review will discuss the risks and benefits of available options for the treatment of thyrotoxicosis during pregnancy, to mitigate the risks of fetal hyperthyroidism.

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Background: Cardiac arrest is a common and devastating emergency of both the heart and brain. More than 380,000 patients suffer out-of-hospital cardiac arrest annually in the USA. Induced cooling of comatose patients markedly improved neurological and functional outcomes in pivotal randomized clinical trials, but the optimal duration of therapeutic hypothermia has not yet been established.

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Multidisciplinary Management of an Internal Carotid Artery Aneurysm Near the Skull Base.

Cureus

June 2024

Department of Otolaryngology-Head and Neck Surgery, Hawaii Permanente Medical Group, Kaiser Moanalua Medical Center, Honolulu, USA.

Article Synopsis
  • Extracranial carotid artery aneurysms (ECAAs) are uncommon when compared to other peripheral artery aneurysms, with no established treatment guidelines available.
  • A case study details a 59-year-old woman who had a 2.6 cm right internal carotid artery aneurysm found incidentally through a CT scan.
  • The aneurysm was surgically excised using a transcervical method, followed by end-to-end anastomosis with a graft from the great saphenous vein, showcasing a unique multidisciplinary approach involving multiple medical specialties.
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Importance: Preeclampsia has direct influences on a developing fetus and may impact postnatal health, and fetal growth restriction (FGR) is often seen co-occurring with preeclampsia. The development of children born very preterm after preeclampsia diagnosis with and without FGR is not well characterized.

Objective: To examine the associations of preeclampsia and FGR with developmental and/or behavioral outcomes in a cohort of very preterm infants.

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Statistical Assessment of the Effectiveness of Multiple COVID-19 Vaccinations on Daily Confirmed Cases in Seoul City.

Cureus

May 2024

Department of Preventive Medicine, Defense Health Agency, Area IV, Daegu, KOR.

This study investigates the effectiveness of multiple COVID-19 vaccinations on daily confirmed cases in Seoul City. Utilizing comprehensive data on vaccinated individuals and confirmed cases sourced from the official website of the Korean Ministry of the Interior and Safety, we conducted detailed statistical analyses to assess the impact of each vaccination dose. The study covers data from April 21, 2021, to September 29, 2022.

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Purpose Of Review: The burden of epilepsy is complex and consists of elements directly related to acute seizures as well as those associated with living with a chronic neurologic disorder. The purpose of this systematic review was to characterize short-term burdens of seizures and to explore the potential value of acute treatments to mitigate these burdens apart from reducing the risk of status epilepticus.

Recent Findings: A systematic literature search was conducted using PubMed to identify articles published from January 1, 2017, to June 22, 2023, that described short-term burdens and acute treatments of seizures.

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In this case report, we present the development of catastrophic antiphospholipid syndrome (CAPS), a rare and potentially fatal consequence of systemic lupus erythematosus (SLE), in a 33-year-old Micronesian woman. CAPS is characterized by extensive arterial thrombosis and multiorgan failure. The patient first showed signs of neuropsychiatric symptoms, brain infarctions on imaging, and severe hypoxic respiratory failure brought into the hospital by diffuse alveolar hemorrhage (DAH) along with lupus nephritis (LN).

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Background: Intravascular ultrasound (IVUS) facilitates detailed visualization of endoluminal anatomy not adequately appreciated on conventional angiography. However, it is unclear if IVUS use improves clinical outcomes of peripheral vascular interventions (PVIs) for peripheral arterial disease. This study aimed to evaluate the impact of IVUS on 1-year outcomes of PVI in the vascular quality initiative (VQI).

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is an uncommon parasitic disease contracted through the consumption of undercooked pork. We report the case of a 59-year-old man with a history of bicuspid aortic valve with recent travel to the Philippines and consumption of raw pork presenting with progressive myalgia and hypereosinophilia (nadir 12,940/uL) in profound cardiogenic shock in the setting of critical aortic stenosis. He underwent emergent balloon valvuloplasty, which was complicated by aortic insufficiency.

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Objective: Understand how high-risk infants' development changes over time. Examine whether NICU Network Neurobehavioral Scale (NNNS) profiles are associated with decrements in developmental outcomes between ages 2 and 3 years in infants born very preterm.

Study Design: The Neonatal Outcomes for Very preterm Infants (NOVI) cohort is a multisite prospective study of 704 preterm infants born <30 weeks' gestation across nine university and VON affiliated NICUs.

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Objective: To determine the incidence of late onset hearing loss and associated risk factors in very low birth weight (VLBW) infants.

Study Design: Retrospective study (2003-2015) of post-discharge hearing outcomes and risk factors in the VLBW infant population, before and after the institution of a standardized follow-up program.

Results: Late onset hearing loss increased from 2.

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A 63-year-old male with stage IV hepatocellular carcinoma (HCC), accompanied by lung and adrenal metastases, presented with oral bleeding. Physical examination disclosed bleeding from the tonsillar mass. A head and neck computed tomography identified a 2.

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Blastoid mantle cell lymphoma (MCL) is an extremely rare neoplasm with a dismal prognosis. MCL with an initial presentation in the oral cavity has been rarely reported. This report describes a 75-year-old male who presented with an oropharyngeal mass causing dysphonia and intermittent hypoxia.

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In the State of Hawaii, previous research has suggested that minority groups such as Native Hawaiians and Other Pacific Islanders are disproportionately affected by mental health disorders and have less access to mental health services. The purpose of this study was to determine if similar disparities in the prevalence of psychiatric disorders among different ethnic groups are also present among Hawaii's houseless population. A retrospective chart review of records from one of Oahu's major houseless outreach clinics was performed to gather patient demographics and reported histories of psychiatric diagnoses.

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Gastric adenocarcinoma location and postoperative complication rates in Asian patients: A 2014-2019 NSQIP analysis.

Am J Surg

January 2024

Department of Surgery, University of Hawaii John A. Burns School of Medicine, 1356 Lusitana Street, Queen's University Tower, Honolulu, HI, 96813, United States.

Background: Asian gastric cancer patients have higher long-term survival rates post-gastrectomy. This study compares 30-day post-gastrectomy outcomes between Asians and non-Asians.

Methods: Gastric cancer patients undergoing elective gastrectomies were identified in 2014-2019 NSQIP datasets (n ​= ​1,438).

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Examine the association between mobility device use and changes in a frailty index (FI) over one year in community-dwelling older adults with mobility limitations. Analyses utilized 2015-2016 data from the National Health and Aging Trends Study community-dwelling older adults ( = 3934). We calculated a validated 40-item deficit accumulation frailty index (FI) in 2015 and 2016 and compared one year change in FI in older adults with/without canes or walkers using multivariable logistic regression.

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