Building Resilience in Medical Students: "Strengthening You to Strengthen Them".

Medical students, like many health professional students, are at risk for burnout and other negative well-being outcomes. Research suggests that building resilience may help to mitigate these risks. A multi-disciplinary team developed, delivered, and evaluated a training on building resilience for medical students entitled, "Resilience for Health Providers - Strengthening You to Strengthen Them.

Alcohol-Induced & Drug-Induced Deaths in Hawai'i During the COVID-19 Pandemic.

During the COVID-19 pandemic, there was a marked increase in alcohol and drug-induced deaths. In the US, there was a rapid increase in the rate of alcohol- and drug-induced deaths within the first year of the COVID-19 pandemic compared to pre-pandemic years. This study examines mortality data within Hawai'i to assess both alcohol and drug-induced mortality during the pandemic compared to the nation overall.

Acclimation and size influence predation, growth, and survival of sexually produced Diploria labyrinthiformis used in restoration.

Stony coral tissue loss disease (SCTLD) has swept through Florida reefs and caused mass mortality of numerous coral species. In the wake of these losses, efforts are underway to propagate coral species impacted by SCTLD and promote population recovery. However, numerous knowledge gaps must be addressed to effectively grow, outplant, and restore populations of the slower growing, massive species that were lost.

Long-term persistency of a strong non-dipole field in the South Atlantic.

Earth's magnetic field exhibits a dominant dipole morphology. Notwithstanding, significant deviations from the dipole are evident today, particularly the South Atlantic Anomaly (SAA), characterized by anomalously low-field intensity and high directional variability, diminishing the field's shielding effect. To assess the persistence of SAA-like features over multimillion-year scales, we combine paleomagnetic data from Trindade Island (20°30'S, 29°22'W) with an evaluation of paleosecular variation (PSV) over the past 10 Myr.

Co-designing Medication Optimization Patient-Centered Outcomes Research With Older People and Caregivers as Research Partners.

Additional evidence is required to address the unintended consequences of medication use in older people and the required caregiver support. To inform priorities for future research efforts, different stakeholder perspectives are needed, including those of older people, caregivers, clinicians, and researchers. To develop a co-designed medication-related research agenda.

Recruitment and Retention in the National Diabetes Prevention Program Lifestyle Change Program in Two Federally Qualified Health Centers in Rural Hawai'i.

Prediabetes disproportionately affects racial and ethnic minority groups in Hawai'i. The National Diabetes Prevention Program lifestyle change program (National DPP LCP) decreases the risk of developing diabetes. However, enrolling and retaining participants is a challenge for program providers.

Experimental coral reef communities transform yet persist under mitigated future ocean warming and acidification.

Coral reefs are among the most sensitive ecosystems affected by ocean warming and acidification, and are predicted to collapse over the next few decades. Reefs are predicted to shift from net accreting calcifier-dominated systems with exceptionally high biodiversity to net eroding algal-dominated systems with dramatically reduced biodiversity. Here, we present a two-year experimental study examining the responses of entire mesocosm coral reef communities to warming (+2 °C), acidification (-0.

Representation of Native Hawaiian and Pacific Islander Individuals in Clinical Trials.

Importance: Having diverse participants in clinical trials ensures new drug products work well across different demographic groups, making health care safer and more effective for everyone. Information on the extent of Native Hawaiian and Pacific Islander participation in clinical trials is limited.

Objective: To examine representation of Native Hawaiian and Pacific Islanders in clinical trials leading to the first US Food and Drug Administration (FDA) approvals for the 10 drug products with the top worldwide sales forecasts in 2024.

Experimental and theoretical study of the Sn-O bond formation between atomic tin and molecular oxygen.

The merging of the electronic structure calculations and crossed beam experiments expose the reaction dynamics in the tin (Sn, P) - molecular oxygen (O, XΣ-g) system yielding tin monoxide (SnO, XΣ) along with ground state atomic oxygen O(P). The reaction can be initiated on the triplet and singlet surfaces addition of tin to the oxygen atom leading to linear, bent, and/or triangular reaction intermediates. On both the triplet and singlet surfaces, formation of the tin dioxide structure is required prior to unimolecular decomposition to SnO(XΣ) and O(P).

Clonality contributes to the spread of Avrainvillea lacerata (Bryopsidales, Chlorophyta) in Hawai'i.

The relative rates of sexual versus asexual reproduction influence the partitioning of genetic diversity within and among populations. During range expansions, asexual reproduction often facilitates colonization and establishment. The arrival of the green alga Avrainvillea lacerata has caused shifts in habitat structure and community assemblages since its discovery in 1981 offshore of O'ahu, Hawai'i.

Whole-exome profiles of inflammatory breast cancer and pathological response to neoadjuvant chemotherapy.

Background: Neoadjuvant chemotherapy (NACT) became a standard treatment strategy for patients with inflammatory breast cancer (IBC) because of high disease aggressiveness. However, given the heterogeneity of IBC, no molecular feature reliably predicts the response to chemotherapy. Whole-exome sequencing (WES) of clinical tumor samples provides an opportunity to identify genomic alterations associated with chemosensitivity.

Cancer prevention and control in the USAPI: Participatory development and partnership - the voyage.

Charting a course to achieve cancer prevention and control in several sovereign Pacific Island nations and US Pacific Island Territories has been a challenging and dynamic process. Partners and stakeholders from these communities have developed the infrastructure to achieve cancer control in the region. This narrative is about the Pacific Cancer Control voyagers in the region, who they are, where they hope to go, and the voyaging canoe on which they journey.

"Allowing space for voice…all our voices:" Understanding Ho'ouna Pono implementation through educational leadership perspectives in rural Hawai'i schools.

Epidemiological research over the past two decades has highlighted substance use disparities that affect Native Hawaiian and Pacific Islander youth, and the lack of effective approaches to address such disparities (Okamoto et al., 2019). The Ho'ouna Pono curriculum is a culturally grounded, teacher-implemented, video-enhanced substance use prevention program that has demonstrated efficacy in rural Hawai'i in a large-scale trial (Okamoto et al.

Eukaryotic viruses encode the ribosomal protein eL40.

Viruses in the phylum are large, complex and have an exceptionally diverse metabolic repertoire. Some encode hundreds of products involved in the translation of mRNA into protein, but none was known to encode any of the proteins in ribosomes, the central engines of translation. With the discovery of the eL40 gene in FloV-SA2, we report the first example of a eukaryotic virus encoding a ribosomal protein and show that this gene is also present and expressed in other uncultivated marine giant viruses.

Explosion Detection Using Smartphones: Ensemble Learning with the Smartphone High-Explosive Audio Recordings Dataset and the ESC-50 Dataset.

Explosion monitoring is performed by infrasound and seismoacoustic sensor networks that are distributed globally, regionally, and locally. However, these networks are unevenly and sparsely distributed, especially at the local scale, as maintaining and deploying networks is costly. With increasing interest in smaller-yield explosions, the need for more dense networks has increased.

Differences in Breast Cancer Subtypes among Racial/Ethnic Groups.

Background: Differences in the incidence of breast cancer subtypes among racial/ethnic groups have been evaluated as a contributing factor in disparities seen in breast cancer prognosis. We evaluated new breast cancer cases in Hawai'i to determine if there were subtype differences according to race/ethnicity that may contribute to known disparities.

Methods: We reviewed 4591 cases of women diagnosed with breast cancer from two large tumor registries between 2015 and 2022.

The cultural adaptation and psychometric evaluation of the Mothers on Respect Index for Native Hawaiians and Pacific Islanders.

Background: Native Hawaiian and Pacific Islanders (NHPI) are disproportionately burdened by pregnancy-related deaths in the United States and have the lowest engagement in prenatal care compared to all other US racial groups. Aside from access barriers, studies suggest that NHPI face challenges with patient-clinician communication, perceived discrimination, and cultural conflicts within healthcare settings. This paper describes the cultural adaptation of the 14-item Mothers On Respect index for NHPI, originally developed by Vedam et al.

Popularity and parity assessment for more inclusive and balanced aquaculture development.

Aquaculture, a rapidly expanding food production system, holds promise for improving global food security and resilience. However, imbalanced growth has led to a highly uneven distribution of aquaculture production among countries, a concern that has not been comprehensively examined. This paper fills this knowledge gap by developing an innovative indicator system to assess this issue based on aquaculture development in ~ 200 countries over five decades.

Interconnectedness of mindfulness facets and their impact on mental health outcomes in Asian American and European American college students: A network approach.

Despite extensive research supporting the effectiveness of mindfulness-based interventions, the understanding of the dynamic connections between various mindfulness facets, particularly across diverse cultures, remained limited. This study aimed to investigate the networks among mindfulness aspects across different cultural backgrounds and their individual associations with mental health and well-being. Using the data collected from 710 undergraduate students in Hawaii (445 Asian Americans, 265 European Americans), we constructed sparse networks for each group to investigate their centrality index.

Circulating cancer-associated macrophage-like cells and macrophage-related cytokines in obese patients with advanced breast cancer who undergo neoadjuvant chemotherapy.

Cancer-associated macrophage-like cells (CAMLs) are rare, gigantic, and atypical circulating cells found exclusively in the peripheral blood of patients with solid cancers. Obesity-induced hypoxia attracts macrophages to the tumor microenvironment, where they contribute to establishing chronic inflammation, leading to cancer progression. We hypothesized that obese patients with advanced breast cancer may have CAML profiles different from those of nonobese patients, and these profiles may correlate with proinflammatory markers or other macrophage-related markers.