In Vitro Degradation of Electrospun Poly(Lactic-Co-Glycolic Acid) (PLGA) for Oral Mucosa Regeneration.

Poly(lactic-co-glycolic acid) (PLGA) has been used in the field of tissue engineering as a scaffold due to its good biocompatibility, biodegradability and mechanical strength. With the aim to explore the degradability of PLGA electrospun nonwoven structures for oral mucosa tissue engineering applications, non-irradiated and gamma irradiated nonwovens were immersed in three different solutions, in which simulated body fluid (SBF) and artificial saliva are important for future oral mucosa tissue engineering. The nonwovens were immersed for 7, 15 and 30 days in SBF, culture media (DMEM) and artificial saliva at 37 °C.

Synthesis of Hierarchical Zeolites with Morphology Control: Plain and Hollow Spherical Beads of Silicalite-1 Nanosheets.

Binderless pure silica zeolites (zeosils) spheres and hollow spheres with a diameter of 20 µm composed of silicalite-1 nanosheets particles were prepared by pseudomorphic transformation of spherical silica beads using different temperatures (110, 130, and 150 °C) and treatment times (1-5 days) in order to adapt the local dissolution rate of silica to the crystallization rate of silicalite-1 nanosheets allowing to preserve the initial morphology of the silica beads. Fully crystalline beads of 20 µm were obtained at 110 °C for 5 days, whereas hollow spheres similar in size were synthesized at higher temperatures. The crystallization process seems to begin at the outer surface of the amorphous silica beads and spreads with the time in the interior of the beads leading to a dissolution of the inner amorphous part of the beads to create zeosil hollow spheres for the highest treatment temperatures (130 and 150 °C).

Effect of Fabric Architecture on Tensile Behaviour of the High-Molecular-Weight Polyethylene 3-Dimensional Interlock Composite Reinforcements.

As promising fibrous reinforcements in the thick composites manufacturing, 3-dimensional warp interlock fabrics (3DWIFs) are recognised more and more in the industry for their outstanding mechanical properties compared to the 2D laminates. The present work shows the influence of the fabric's architecture on the tensile behaviour of 3DWIFs. Five kinds of 3D fabrics with different interlock structures have been designed according to the main category of binding warp yarn evolution.

Optimization of hybrid treatment of olive mill wastewaters through impregnation onto raw cypress sawdust and electrocoagulation.

This research investigation proposes a new method for sustainable olive mill wastewater (OMW) treatment and handling. It is based on the combination of its impregnation onto raw cypress sawdust (RCS) followed by electrocoagulation. The retention of OMW compounds onto various RCS doses show an important decrease of its chemical oxygen demand (COD) and its main cation and anion content.

A New Phosphine for Efficient Free Radical Polymerization under Air.

A new phosphine is proposed as efficient coinitiator for camphorquinone (CQ)-based photoinitiating systems for the free radical polymerization of (meth)acrylates. Remarkably, this new co-initiator can exhibit two functionalities: a phosphine moiety to overcome oxygen inhibition and an iodonium salt moiety as counter cation to initiate the polymerization process. Excellent polymerization performances in the presence of CQ for the free radical polymerization of methacrylates under blue light are observed, and amine-free systems can be easily developed from the proposed structure.

Graph-based description of tertiary lymphoid organs at single-cell level.

Our aim is to complement observer-dependent approaches of immune cell evaluation in microscopy images with reproducible measures for spatial composition of lymphocytic infiltrates. Analyzing such patterns of inflammation is becoming increasingly important for therapeutic decisions, for example in transplantation medicine or cancer immunology. We developed a graph-based assessment of lymphocyte clustering in full whole slide images.

IoT-Based Smart Irrigation Systems: An Overview on the Recent Trends on Sensors and IoT Systems for Irrigation in Precision Agriculture.

Water management is paramount in countries with water scarcity. This also affects agriculture, as a large amount of water is dedicated to that use. The possible consequences of global warming lead to the consideration of creating water adaptation measures to ensure the availability of water for food production and consumption.

A new safranin based three-component photoinitiating system for high resolution and low shrinkage printed parts digital light processing.

Additive manufacturing or 3D printing has attracted the interest of researchers in industry and academia because of its outstanding features. In this study, a new three-component photoinitiating system (PIS) consisting of safranin O (SFH), thiol derivatives and diphenyl iodonium salt was used for the free radical photopolymerization of a diacrylate monomer (SR349) in DLP 3D printing. The photoinitiating characteristics of this PIS were evaluated and advantageously compared to those of a conventional PI (TPO) by using RT-FTIR.

Synthesis of novel biocomposite powder for simultaneous removal of hazardous ciprofloxacin and methylene blue: Central composite design, kinetic and isotherm studies using Brouers-Sotolongo family models.

Over the past decades, extensive efforts have been made to use biomass-based-materials for wastewater-treatment. The first purpose of this study was to develop and characterize regenerated-reed/reed-charcoal (RR-ChR), an enhanced biosorbent from Tunisian-reed (Phragmites-australis). The second aim was to assess and optimize the RR-ChR use for the removal of binary ciprofloxacin antibiotic (CIP) and methylene blue dye (MB), using Central Composite Design under Response Surface methodology.

PARS, a system combining semantic technologies with multiple criteria decision aiding for supporting antibiotic prescriptions.

Objective: Motivated by the well documented worldwide spread of adverse drug events, as well as the increased danger of antibiotic resistance (caused mainly by inappropriate prescribing and overuse), we propose a novel recommendation system for antibiotic prescription (PARS).

Method: Our approach is based on the combination of semantic technologies with MCDA (Multiple Criteria Decision Aiding) that allowed us to build a two level decision support model. Given a specific domain, the approach assesses the adequacy of an alternative/action (prescription of antibiotic) for a specific subject (patient) with an issue (bacterial infection) in a given context (medical).

Dynamic adaptation of mesenchymal stem cell physiology upon exposure to surface micropatterns.

Human mesenchymal stem (hMSCs) are defined as multi-potent colony-forming cells expressing a specific subset of plasma membrane markers when grown on flat tissue culture polystyrene. However, as soon as hMSCs are used for transplantation, they are exposed to a 3D environment, which can strongly impact cell physiology and influence proliferation, differentiation and metabolism. Strategies to control in vivo hMSC behavior, for instance in stem cell transplantation or cancer treatment, are skewed by the un-physiological flatness of the standard well plates.

Micellization of poly(2-vinylpyrridine)-b-poly(cyclohexyl methacrylate) (P2VP-b-PCHMA) block copolymers and their interpolymer complex formation in non-aqueous medium.

Hypothesis: The interpolymer complex formation between poly(vinylpyridine)-based polymers with poly(acrylic acid) (PAA), in aqueous or organic medium, is driven by the hydrogen-bonding complexation. Well-defined nanostructures, with specific practical applications, may be obtained by taking advantage of such non-covalent interactions.

Experiments: Poly(2-vinylpyridine)-b-poly(cyclohexyl methacrylate) (P2VP-b-PCHMA) and poly(2-vinylpyridine)-b-poly(t-butyl methacrylate)-b-poly(cyclohexyl methacrylate) (P2VP-b-PtBuMA-b-PCHMA) copolymers were synthesized by sequential anionic polymerization.

Chitosan grafted-poly(ethylene glycol) methacrylate nanoparticles as carrier for controlled release of bevacizumab.

The aim of the present study is to obtain, for the first time, polymeric nanocarriers based on the chitosan grafted-poly(ethylene glycol) methacrylate derivative. The strategy involves the use of chitosan grafted-poly(ethylene glycol) methacrylate with high solubility in water, obtained via Michael addition, in order to prepare potentially non-toxic micro/nanoparticles (MNPs). By modifying chitosan, its solubility in aqueous media was improved.

A new synthetic pathway based on one-pot sequential aza-Michael addition and photoCuAAC click reactions.

A solvent-free process is described for the synthesis of tailor-made molecules from a one-pot, two-step approach combining aza-Michael addition and photoinduced copper(i) catalysed azide-alkyne (photo-CuAAC) reactions. After the first reaction between an amine and an acrylate, cycloaddition between an azide and an alkyne is activated by light irradiation in the presence of a copper complex. The kinetics of the aza-Michael addition and photo-CuAAC reaction were investigated by liquid state H NMR spectroscopy and real-time Fourier transform infrared spectroscopy.

Visual expertise for print in schizophrenia: Analysis of the N170 component.

Reading deficits have been reported for patients suffering from schizophrenia namely, specific phonological processing deficits. Phonological processing skills are crucial in the learning-to-read process as they are necessary to develop visual expertise for print, which reflects the neural specialization for print. The present study is the first to test visual expertise for print in patients suffering from schizophrenia by measuring the N170 component.

Toward a standard ontology of surgical process models.

Purpose: The development of common ontologies has recently been identified as one of the key challenges in the emerging field of surgical data science (SDS). However, past and existing initiatives in the domain of surgery have mainly been focussing on individual groups and failed to achieve widespread international acceptance by the research community. To address this challenge, the authors of this paper launched a European initiative-OntoSPM Collaborative Action-with the goal of establishing a framework for joint development of ontologies in the field of SDS.

Sequential surgical signatures in micro-suturing task.

Purpose: Surgical processes are generally only studied by identifying differences in populations such as participants or level of expertise. But the similarity between this population is also important in understanding the process. We therefore proposed to study these two aspects.

Surgical skills: Can learning curves be computed from recordings of surgical activities?

Purpose: Surgery is one of the riskiest and most important medical acts that are performed today. The need to improve patient outcomes and surgeon training, and to reduce the costs of surgery, has motivated the equipment of operating rooms with sensors that record surgical interventions. The richness and complexity of the data that are collected call for new methods to support computer-assisted surgery.

Self-Assembly of Block and Graft Copolymers in Organic Solvents: An Overview of Recent Advances.

This review is an attempt to update the recent advances in the self-assembly of amphiphilic block and graft copolymers. Their micellization behavior is highlighted for linear AB, ABC triblock terpolymers, and graft structures in non-aqueous selective polar and non-polar solvents, including solvent mixtures and ionic liquids. The micellar characteristics, such as particle size, aggregation number, and morphology, are examined as a function of the copolymers' architecture and molecular characteristics.

Role of the Nucleus as a Sensor of Cell Environment Topography.

The proper integration of biophysical cues from the cell vicinity is crucial for cells to maintain homeostasis, cooperate with other cells within the tissues, and properly fulfill their biological function. It is therefore crucial to fully understand how cells integrate these extracellular signals for tissue engineering and regenerative medicine. Topography has emerged as a prominent component of the cellular microenvironment that has pleiotropic effects on cell behavior.

In Situ Generated Ruthenium-Arene Catalyst for Photoactivated Ring-Opening Metathesis Polymerization through Photolatent N-Heterocyclic Carbene Ligand.

1,3-Bis(mesityl)imidazolium tetraphenylborate (IMesH BPh ) can be synthesized in one step by anion metathesis between the corresponding imidazolium chloride and sodium tetraphenylborate. In the presence of 2-isopropylthioxanthone (sensitizer), an IMes N-heterocyclic carbene (NHC) ligand can be photogenerated under irradiation at 365 nm through coupled electron/proton transfer reactions. By combining this tandem NHC photogenerator system with metathesis inactive [RuCl (p-cymene)] precatalyst, the highly active RuCl (p-cymene)(IMes) complex can be formed in situ, enabling a complete ring-opening metathesis polymerization (ROMP) of norbornene in the matter of minutes at room temperature.

Sustaining attention to simple visual tasks: a central deficit in schizophrenia? A systematic review.

Impairments in sustained attention, that is, the ability to achieve and maintain the focus of cognitive activity on a given stimulation source or task, have been described as central to schizophrenia. Today, sustained attention deficit is still considered as a hallmark of schizophrenia. Nevertheless, current findings on this topic are not consistent.

Finding discriminative and interpretable patterns in sequences of surgical activities.

Objective: Surgery is one of the riskiest and most important medical acts that is performed today. Understanding the ways in which surgeries are similar or different from each other is of major interest to understand and analyze surgical behaviors. This article addresses the issue of identifying discriminative patterns of surgical practice from recordings of surgeries.

Sustained attention ability in schizophrenia: Investigation of conflict monitoring mechanisms.

Objective: The main goal of the current study was to assess, with a time-on-task approach, sustained attention ability in schizophrenia, and to investigate conflict monitoring underlying this ability.

Methods: Behavioral and event-related potentials data (N2 and P3a amplitudes) were recorded in a long-lasting sustained attention Go/NoGo task (sustained attention to response task, SART), over a period of 30min, in 29 patients with schizophrenia and 29 pair-matched healthy subjects.

Results: Our results revealed spared sustained attention ability in patients throughout the task.