Architecture-Aware Augmentation: A Hybrid Deep Learning and Machine Learning Approach for Enhanced Parkinson's Disease Detection.

Parkinson's Disease (PD) is a progressive neurodegenerative disorder affecting millions worldwide. Early detection is crucial for improving patient outcomes. Spiral drawing analysis has emerged as a non-invasive tool to detect early motor impairments associated with PD.

Node Localization Method in Wireless Sensor Networks Using Combined Crow Search and the Weighted Centroid Method.

Node localization is critical for accessing diverse nodes that provide services in remote places. Single-anchor localization techniques suffer co-linearity, performing poorly. The reliable multiple anchor node selection method is computationally intensive and requires a lot of processing power and time to identify suitable anchor nodes.

Heat-induced morphological changes in silver nanowires deposited on a patterned silicon substrate.

Metallic nanowires (NWs) are sensitive to heat treatment and can split into shorter fragments within minutes at temperatures far below the melting point. This process can hinder the functioning of NW-based devices that are subject to relatively mild temperatures. Commonly, heat-induced fragmentation of NWs is attributed to the interplay between heat-enhanced diffusion and Rayleigh instability.

Investigation of chemical, physical and morpho-mechanical properties of banana-plantain stalk fibers for ropes and woven fabrics used in composite and limited-lifespan geotextile.

This study aimed to assess the potential of banana-plantain stalk fibers (BPSF) as a raw material for ropes and fabrics used in composites and geotextiles. Fibers were obtained by Biological retting and ropes used for geotextile weaving were obtained by three-strand twisting in order to optimize the mechanical properties of geostalk. The thermal, physical, chemical and mechanical characteristics of the fibers were studied in order to assess the impact of the extraction process on fiber performance.

Comprehensive investigation of recycled PVC powder.

This study constitutes a comprehensive investigation centred on comprehending the behaviour and characteristics of recycled polyvinyl chloride (PVC) powders. The overarching objective is to successfully conclude the initial research phase, during which PVC-coated fabric offcuts undergo a transformation into PVC powder while achieving complete separation from polyethylene terephthalate fibres. The study entails a qualitative description of the morphology of PVC powder particles, employing an optical microscope to distinguish the diverse shapes exhibited by these particles.

Deconstructing Best-in-Class Neoglycoclusters as a Tool for Dissecting Key Multivalent Processes in Glycosidase Inhibition.

Multivalency represents an appealing option to modulate selectivity in enzyme inhibition and transform moderate glycosidase inhibitors into highly potent ones. The rational design of multivalent inhibitors is however challenging because global affinity enhancement relies on several interconnected local mechanistic events, whose relative impact is unknown. So far, the largest multivalent effects ever reported for a non-polymeric glycosidase inhibitor have been obtained with cyclopeptoid-based inhibitors of Jack bean α-mannosidase (JBα-man).

Poly(ethylene glycol) Methyl Ether Acrylate-Grafted Chitosan-Based Micro- and Nanoparticles as a Drug Delivery System for Antibiotics.

Nanotechnology is the science of creating materials at the nanoscale by using various devices, structures, and systems that are often inspired by nature. Micro- and nanoparticles (MPs, NPs) are examples of such materials that have unique properties and can be used as carriers for delivering drugs for different biomedical applications. Chitosan (CS) is a natural polysaccharide that has been widely studied, but it has a problem with low water solubility at neutral or basic pH, which limits its processability.

Use of waste marble powder for the synthesis of novel calcium-rich biochar: Characterization and application for phosphorus recovery in continuous stirring tank reactors.

This study investigates-for the first time-the synthesis of a novel Ca-rich biochar (N-Ca-B) and its potential use for phosphorus (P) recovery from both synthetic solutions (SS) and treated urban wastewater (TUW) in a continuous stirring tank reactor (CSTR) mode. The novel biochar was synthesized by pyrolysis at 900 °C of a mixture composed of three different materials: animal biomass (poultry manure; PM), lignocellulosic waste (date palm fronds; DPFs), and abundant mineral waste (waste marble powder; WMP). Characterization of N-Ca-B showed that it has good textural properties: well-developed porosity, and high specific surface area.

Synthesis of 2-amidoindenone derivatives through an ynamide carbosilylation/Houben-Hoesch cyclization 2-step sequence.

Herein we report the efficient and selective two-step synthesis of various 3-silyl-2-amidoindenones from easily accessible ynamides. This sequence involves a regio- and stereo-selective silylcyanation followed by a Houben-Hoesch type cyclization. Thanks to post-transformations, various 3-substituted 2-amidoindenones could be obtained.

A guide to Whittle maximum likelihood estimator in MATLAB.

The assessment of physiological complexity via the estimation of monofractal exponents or multifractal spectra of biological signals is a recent field of research that allows detection of relevant and original information for health, learning, or autonomy preservation. This tutorial aims at introducing Whittle's maximum likelihood estimator (MLE) that estimates the monofractal exponent of time series. After introducing Whittle's maximum likelihood estimator and presenting each of the steps leading to the construction of the algorithm, this tutorial discusses the performance of this estimator by comparing it to the widely used detrended fluctuation analysis (DFA).

Facile synthesis of double-cross-linked alginate-based hydrogel: Characterization and use in a context of circular economy for cationic dye removal.

Hydrogels based on natural polysaccharides have received special attention in the last decade due to their interesting features, such as availability, biocompatibility, biodegradability and safety. Such characteristics may make them sustainable and eco-friendly materials for water and wastewater treatment, meeting the concept of circular economy. In this study, a novel double-cross-linked alginate-based hydrogel has been successfully synthesized using epichlorhydrin and sodium trimetaphosphate (STMP) as cross-linker agents and then used for the removal of methylene blue (MB) dye under different operating conditions.

Degradation phenomena on last generations of polyethylene terephthalate knitted vascular prostheses.

Objectives: The aim of this study was to analyze a series of new generations of explanted knitted polyethylene terephthalate (PET) vascular grafts (VGs) presenting nonanastomotic degradations according to preoperative computed tomography angiography (CTA) when available in order to better understand the mechanisms leading to rupture.

Methods: Explanted knitted PET VGs were collected as part of the Geprovas European Collaborative Retrieval Program. VGs implanted after 1990 presenting a nonanastomotic rupture of the fabric were included.

Short report on a syllable-based intervention to improve phonemic awareness and reading in children with DLD.

With fragile phonological representations, children with developmental language disorder (DLD) risk failure when learning to read. The study reported that teaching letters-to-syllable relationships can improve phonemic awareness skills or reading performances of three French-speaking children with DLD, using a single case methodology with an AB design. These findings are promising for children at risk of reading disability and extend current knowledge concerning syllable-based teaching for developing literacy.

Analysis of Thermomechanical Behavior of the Tubular Braided Fabrics with Flax/Polyamide Commingled Yarns.

Flax fibers are widely used as the strongest natural fibers in composite parts with advanced structures. Due to their excellent mechanical properties and recyclability, they have attracted more attention from the aviation and automotive industries, etc. These composite parts are usually obtained by preforming reinforcements or prepregs at high temperatures, and their mechanical behaviors are greatly affected by temperature variations.

Short-term cold-water immersion does not alter neuromuscular fatigue development during high-intensity intermittent exercise.

Aims: Pre-exercise cold-water immersion affects physical performance under ambient environment, however the mechanisms leading to this decrease remains to be elucidated. The purpose was to determine whether short-term lower-body immersion in cold water could induce acute changes in the development of neuromuscular fatigue after high-intensity exercise.

Methods: Ten participants performed on two separate visits a fatigue task (60 intermittent isometric maximal voluntary contractions maintained over 3 s and spaced by 2 s of recovery) once after lower-body cold-water immersion (Pre-Cooling, 6 min at 8.

The perception of circular economy in the framework of fashion industry.

Humanity's three main components are energy, food and clothing. Each of us, individually and collectively, contributes to climate change and CO emissions, natural resource consumption, and social attitudes and behaviour. Global fashion trends are expected to increase in value from 1.

3D printing of LEGO® like designs with tailored release profiles for treatment of sleep disorder.

3D printed LEGO®-like designs are an attractive approach for the development of compartmental delivery systems due to their potential for dose personalisation through the customisation of drug release profiles. Additive manufacturing technologies such as Fused Deposition Modelling (FDM) are ideal for the printing of structures with complex geometries and various sizes. This study is a paradigm for the fabrication of 3D printed LEGO® -like tablets by altering the design of the modular units and the filament composition for the delivery of different drug substances.

Weakly Supervised Learning using Attention gates for colon cancer histopathological image segmentation.

Recently, Artificial Intelligence namely Deep Learning methods have revolutionized a wide range of domains and applications. Besides, Digital Pathology has so far played a major role in the diagnosis and the prognosis of tumors. However, the characteristics of the Whole Slide Images namely the gigapixel size, high resolution and the shortage of richly labeled samples have hindered the efficiency of classical Machine Learning methods.

In Vitro and In Vivo Cell-Interactions with Electrospun Poly (Lactic-Co-Glycolic Acid) (PLGA): Morphological and Immune Response Analysis.

Random electrospun three-dimensional fiber membranes mimic the extracellular matrix and the interfibrillar spaces promotes the flow of nutrients for cells. Electrospun PLGA membranes were analyzed in vitro and in vivo after being sterilized with gamma radiation and bioactivated with fibronectin or collagen. Madin-Darby Canine Kidney (MDCK) epithelial cells and primary fibroblast-like cells from hamster's cheek paunch proliferated over time on these membranes, evidencing their good biocompatibility.

Biodegradability Assessment of Polyester Copolymers Based on Poly(ethylene adipate) and Poly(ε-caprolactone).

Biodegradable polymers contain chains that are hydrolytically or enzymatically cleaved, resulting in soluble degradation products. Biodegradability is particularly desired in biomedical applications, in which degradation of the polymer ensures clearance from the body and eliminates the need for retrieval or explant. In this study, a homologues series of poly(ε-caprolactone)-b-poly(ethylene adipate)-b-poly(ε-caprolactone) (PCL-b-PEA-b-PCL) block copolymers, with constant PEA molar mass and different PCL sequence lengths was obtained.

Correspondence Between Values of Vertical Loading Rate and Oxygen Consumption During Inclined Running.

Purpose: The aim of this study was to provide a theoretical model to predict the vertical loading rate (VLR) at different slopes and speeds during incline running.

Methods: Twenty-nine healthy subjects running at least once a week performed in a randomized order 4-min running trials on an instrumented treadmill at various speeds (8, 10, 12, and 14 km h) and slopes (- 20%, - 10%, - 5%, 0%, + 5%, + 10%, + 15%, + 20%). Heart rate, gas exchanges and ground reaction forces were recorded.

How visual attention span and phonological skills contribute to N170 print tuning: An EEG study in French dyslexic students.

Developmental dyslexia is a disorder characterized by a sustainable learning deficit in reading. Based on ERP-driven approaches focusing on the visual word form area, electrophysiological studies have pointed a lack of visual expertise for written word recognition in dyslexic readers by contrasting the left-lateralized N170 amplitudes elicited by alphabetic versus non-alphabetic stimuli. Here, we investigated in 22 dyslexic participants and 22 age-matched control subjects how two behavioural abilities potentially affected in dyslexic readers (phonological and visual attention skills) contributed to the N170 expertise during a word detection task.

Chitosan Grafted Poly (Ethylene Glycol) Methyl Ether Acrylate Particulate Hydrogels for Drug Delivery Applications.

Chitosan (CS) crosslinking has been thoroughly investigated, but the chemical reactions leading to submicronic hydrogel formulations pose problems due to various physical/chemical interactions that limit chitosan processability. The current study employs the chemical modification of chitosan by Michael addition of poly (ethylene glycol) methyl ether acrylate (PEGA) to the amine groups to further prepare chitosan particulate hydrogels (CPH). Thus, modified CS is subjected to a double crosslinking, ionic and covalent, in water/oil emulsion.

Bambus[4,6]urils as Dual Scaffolds for Multivalent Iminosugar Presentation and Ion Transport: Access to Unprecedented Glycosidase-Directed Anion Caging Agents.

Bambusurils, BU[4] and BU[6], were used for the first time as multivalent scaffolds to link glycosidases inhibitors derived from 1-deoxynojirimycin (DNJ). Two linear DNJ ligands having six or nine carbon alkyl azido linkers or a trivalent DNJ dendron were grafted onto octapropargylated BU[4] and dodecapropargylated BU[6] using copper-catalyzed cycloaddition (CuAAC) to yield corresponding neoglycobambus[4] and neoglycobambus[6]urils bearing 8 to 24 iminosugars. The inhibition potencies of neoglycoBU[4], neoglycoBU[6] and neoglycoBU[6] caging anions were evaluated against Jack Bean α-mannosidase and compared to monovalent DNJ derivatives.