Identification of polyphenol composition in grape ( cv. Bidaneh Sefid) stem using green extraction methods and LC-MS/MS analysis.

The utilization of grape stems, a by-product of the grape processing industry, as a source of valuable bioactive compounds, particularly polyphenols, has gained attention in recent years. This study aimed to investigate different eco-friendly extraction methods for obtaining polyphenols from grape ( cv. Bidaneh Sefid) stems, focusing on green solvents and innovative techniques.

In Vitro differentiation of hair-follicle bulge stem cells into synaptophysin-expressing neurons: a potential new approach for neuro-regeneration.

Stem cells, particularly bulge hair follicle stem cells (HFSCs), have recently attracted significant interest due to their potential for tissue repair and regeneration. These cells, marked by their expression of Nestin (a neural stem cell marker), suggest the possibility of neural differentiation into neurons. This study investigated the use of retinoic acid (RA) and epidermal growth factor (EGF) to induce HFSC transformation into mature neurons, identified by synaptophysin expression.

DNA binding, and apoptosis-inducing activities of a β-ionone-derived ester in human myeloid leukemia cells: multispectral and molecular dynamic simulation analyses.

β-Ionone is the end-ring counterpart of β-carotenoids, which are widely found in fruits and vegetables. Recent studies have illustrated the antimetastatic, anti-proliferative, and apoptosis-inducing activities of β-ionone both in vitro and in vivo. We aimed to explore the anti-cancer potency of β-Ionone-derived ester, (E)-4-(2,6,6-trimethylcyclohex-1-enyl) but-3-en-2-ylpyrazine-2-carboxylate (4-TM.

Buspirone administration: Influence on growth, spawning, immune response, and stress in female goldfish ().

The current study evaluated the impact of buspirone supplementation on the growth, physiology, stress response, spawning, and immunity in female goldfish (). For this purpose, buspirone was dissolved in absolute methanol and sprayed onto the feed to create four experimental groups: B0 (control), B25 (25 mg kg), B50 (50 mg kg), and B100 (100 mg kg). Fish were fed their respective diets for 56 days and subjected to stress using the air exposure method at the end of the experiment.

Introducing an alternative nonlinear model to characterize the growth curve in ostrich.

By applying a sinusoidal function (as a trigonometric model), this study aimed to introduce this function into ostrich weight development research, using ostrich growth data from the literature and comparing it with some routinely used growth models such as monomolecular, Bridges, Janoschek, logistic, Von Bertalanffy, Richards, Schumacher, Morgan, Chanter, and Weibull. During the fitting of nonlinear regression curves, model performance was evaluated and model behavior was examined. Body weight data of the domestic ostriches used in this study were reported in the Blue Mountain Ostrich Nutrition e-bulletin from three different studies (data sets 1 to 3).

Toxicity of polystyrene nanoplastic and copper oxide nanoparticle in Artemiasalina: Single and combined effects on stress responses.

Nanoparticles, such as copper oxide nanoparticle (CuO NP) and polystyrene nanoplastic (PSNP), are increasingly released into aquatic environments, and pose potential risks to aquatic animals such as brine shrimps. Understanding the toxicity of these nanoparticles, especially when combined, is very important to assess their environmental effects. Therefore, this work describes the toxicity of polystyrene nanoplastic (PSNP) and CuO nanoparticles (CuO NPs) for brine shrimp (Artemiasalina).

Establishing robust ZnO-sodium alginate nanocomposite for dye wastewater treatment: characterization, RSM methodology, and mechanism evaluation.

In today's world, water is a highly valued resource, and enhancing the quality of this natural endowment is a significant concern and a worldwide endeavor. This study sought to purify real wastewater and water tainted with methylene blue (MB) by immobilizing ZnO nanoparticles onto an alginate matrix using a straightforward approach and a three-dimensional structure. After analyzing the impact of , it was determined that 93.

Effects of intravenous tranexamic acid on bleeding during burn surgery: A double-blinded randomized clinical trial.

Blood loss during burn surgery significantly contributes to morbidity and mortality. Tranexamic acid (TXA), an antifibrinolytic agent, is hypothesized to reduce intraoperative bleeding. This double-blinded, randomized clinical trial aimed to assess the efficacy of systemic TXA in severe burn patients (total body surface area [TBSA] > 20 %) undergoing surgery.

The Pattern of Gene Expression ( Family, Muscle Growth Regulatory Factors, and Osteogenesis-Related Genes) Involved in the Growth of Skeletal Muscle in Pikeperch () During Ontogenesis.

The pikeperch () is an economically important freshwater fish and a valuable food with high market acceptance. It is undergoing important changes in growth and regulatory metabolism during the ontogeny. Hence, the current study aims to investigate the mRNA expression of the growth hormone ()/insulin-like growth factor () axis (, , , ), muscle regulatory factors (, , , , , , ), and osteogenesis-related genes (, , , , ) from hatching through day 40th post-hatching (DPH).

and evaluation of the nutritional value of various hydrolyzed feather meals and comparison of their effect on performance and carcass characteristics of broilers.

In the current study, the nutritional value of various hydrolyzed feather meals (HFM) was investigated in two separate experiments (an and an experiment). The experiment was based on a completely randomized design with five replications and seven treatments including (1) Raw feather meal (RFM), (2) HFM by autoclave (Au-HFM), (3) Fermented feather meal (FFM) by (Bl-FFM), (4) FFM by (Bs-FFM), (5) FFM by (An-FFM), (6) FFM by  +  +  (Co-FFM), and (7) HFM by an enzyme (En-HFM). The highest pepsin-pancreatin and apparent ileal CP digestibility were observed in Co-FFM, and the lowest amount belonged to RFM (P < 0.

Amelioration of fructose-induced hepatic lipid accumulation by vitamin D supplementation and high-intensity interval training in male Sprague‒Dawley rats.

Background: Intrahepatic lipid accumulation (IHL), a hallmark of metabolic disorders, is closely associated with de novo lipogenesis (DNL). Notably, fructose feeding increased the DNL. Lifestyle modifications resulting from dietary changes and increased physical activity/exercise can decrease the IHL content.

Influence of different concentrations of milk urea nitrogen on the reproductive performance of Holstein cows.

The purpose of this study was to assess how various MUN levels affected the reproductive performance traits of Iranian Holsteins. The dataset used in this study included reproduction performance records for 16,000 Holstein cows and was gathered by the Animal Breeding Center and Promotion of Animal Products of Iran on 30 large dairy herds during 2018-2021. The MUN concentrations were grouped into four classes: [Formula: see text] mg/dL (MUN1), [Formula: see text] mg/dL (MUN2), [Formula: see text] mg/dL (MUN3), and [Formula: see text] mg/dL (MUN4).

Breeding of new kiwifruit (Actinidia chinensis) cultivars with yellow (golden) fleshed and superior characteristics.

The most widely cultivated species globally is Actinidia deliciosa cv. 'Hayward'. However, in recent years, consumers have shown greater demand for new varieties with novel flesh colour, flavour and appearance in international markets.

Dexamethasone in COVID-19 treatment: Analyzing monotherapy and combination therapy approaches.

The COVID-19 pandemic has prompted the exploration of effective treatment options, with dexamethasone emerging as a key corticosteroid for severe cases. This review evaluates the efficacy and safety of dexamethasone, highlighting its ability to reduce mortality rates, alleviate acute respiratory distress syndrome (ARDS), and mitigate hyperinflammation. While dexamethasone shows therapeutic promise, potential adverse effects-including cardiovascular issues, neuropsychiatric complications, lung infections, and liver damage-necessitate careful monitoring and individualized treatment strategies.

Neuroprotective properties of a thiazolidine-2,4-dione derivative as an inhibitory agent against memory impairment and phosphorylated tau: In vitro and in vivo investigations.

Alzheimer's disease (AD) is the most common form of neurodegeneration that results in memory disorders and cognitive impairment. The present study investigated the neuroprotective effects of the synthesized thiazolidine-2,4-dione derivative, (E)-5-(4-chlorobenzylidene)-3-(2-oxo-2-phenylethyl)thiazolidine-2,4-dione (TZ4C), an inhibitor of p-Tau and memory impairment, using a SH-SY5Y cell model of methamphetamine-induced tauopathy and a scopolamine-induced memory impairment model in Wistar rats. In the present study, the neuroprotective effect of TZ4C was studied in a SH-SY5Y cellular model of methamphetamine-induced (2 mM) tauopathy and a scopolamine-induced (1.

Virtual screening, ADMET prediction, molecular docking, and dynamic simulation studies of natural products as BACE1 inhibitors for the management of Alzheimer's disease.

Alzheimer's disease (AD) is a degenerative neurological disorder that chronically and irreversibly affects memory, cognitive function, learning ability, and organizational skills. Numerous studies have demonstrated BACE1 as a critical therapeutic target for AD, emphasizing the need for specific inhibition of BACE1 to develop effective therapeutics. However, current BACE1 inhibitors have certain limitations.

Anchored Chitosan-Functionalized Magnetite Nanoparticles for Crystal Violet Decolorization from Aqueous Samples.

Introduction: In this research, 3-(triethoxysilyl)propyl isocyanate (TESPIC) functionalized chitosan was successfully synthesized to fabricate silica-coated magnetite nanoparticles (Fe3O4@SiO2-CS MNPs).

Method: The synthesized MNPs were characterized using XRD, FT-IR, SEM, and TEM instruments and were utilized for the decolorization of Crystal Violet cationic dye (CV). The affecting variables controlling CV removal efficiency were investigated using the Taguchi fractional factorial design method (L16 array).

Dietary prebiotic alleviates experimentally induced coccidiosis in broilers.

An experiment was conducted to determine the effects of prebiotic on growth performance and coccidiosis prevention in challenged broilers with Eimeria. A total of 420 1-d-old male Ross 308 chicks were used in a completely randomized design with 7 treatments and 5 replicates with 12 birds in each replication. Dietary treatments were: 1) negative control (without prebiotic and without challenge), 2) positive control (challenged with sporulated oocysts of Eimeria (SOE) without prebiotic), 3) 0.

Lower limbs kinematic analysis during a jump landing task in soccer players with unilateral anterior cruciate ligament reconstruction.

Background: Fatigue leads to an acute decline in muscle strength, altered patterns of lower extremity muscle activation, changes in hip and knee kinematics. In terms of the effects of fatigue on knee joint kinematics during plyometric training, there is still a lack of knowledge regarding kinematic differences between athletes who passed the ACL reconstructions rehabilitation period and healthy athletes. Therefore, this study aimed to compare lower limb joint kinematic parameters between reconstructed cruciate ligament and healthy control soccer players during jump landing in a fatigued setting.

Association between Maternal Exposure to Arsenic during Pregnancy and Risk of Preterm Birth: A Systematic Review and Meta-Analysis.

Background: Several observational studies have suggested that maternal exposure during pregnancy to arsenic is associated with the risk of preterm birth (PTB); however, available evidence is inconsistent. Therefore, we aimed to explore the relation of maternal exposure to arsenic to PTB risk.

Methods: A comprehensive systematic search was carried out from inception to April 2023 in PubMed and Scopus to retrieve all relevant studies.