Apoptosis induction in colon cancer cells (SW480) by BiFeO@Ag nanocomposite synthesized from Chlorella vulgaris extract and evaluation the expression of CASP8, BAX and BCL2 genes.

Background: The use of nanomaterials in cancer diagnosis and treatment has received considerable interest. Preparation of nanoscale complex molecules could be considered to improve the efficacy and minimize toxicity of the product. This work aimed to biosynthesize BiFeO@Ag nanocomposite using the Chlorella vulgaris extract and its cytotoxic effect on colon cancer cell line.

Predicting the quality attributes related to geographical growing regions in red-fleshed kiwifruit by data fusion of electronic nose and computer vision systems.

The ability of a data fusion system composed of a computer vision system (CVS) and an electronic nose (e-nose) was evaluated to predict key physiochemical attributes and distinguish red-fleshed kiwifruit produced in three distinct regions in northern Iran. Color and morphological features from whole and middle-cut kiwifruits, along with the maximum responses of the 13 metal oxide semiconductor (MOS) sensors of an e-nose system, were used as inputs to the data fusion system. Principal component analysis (PCA) revealed that the first two principal components (PCs) extracted from the e-nose features could effectively differentiate kiwifruit samples from different regions.

Effectiveness of Group Cognitive-Behavioral Therapy for Managing Anxiety and Depression in Women Following Hysterectomy for Uterine Cancer.

Objective: Hysterectomy as well as uterine cancer could be associated with a long-term risk of mental disorders. The purpose of this study is to investigate the effectiveness of group cognitive-behavioral therapy (GCBT) in reducing anxiety and depression in women who have undergone hysterectomy for uterine cancer.

Method: This experimental, pretest-post-test study was conducted in an academic hospital.

Regulation of Cellular-Signaling Pathways by Mammalian Proteins Containing Bacterial EPIYA or EPIYA-Like Motifs Predicted to be Phosphorylated.

The effector proteins of several pathogenic bacteria contain the Glu-Pro-Ile--Ala (EPIA) motif or other similar motifs. The EPIYA motif is delivered into the host cells by type III and IV secretion systems, through which its tyrosine residue undergoes phosphorylation by host kinases. These motifs atypically interact with a wide range of Src homology 2 (SH2) domain-containing mammalian proteins through tyrosine phosphorylation, which leads to the perturbation of multiple signaling cascades, the spread of infection, and improved bacterial colonization.

Engineering Human Pancreatic RNase 1 as an Immunotherapeutic Agent for Cancer Therapy Through Computational and Experimental Studies.

Most plant and bacterial toxins are highly immunogenic with non-specific toxic effects. Human ribonucleases are thought to provide a promising basis for reducing the toxic agent's immunogenic properties, which are candidates for cancer therapy. In the cell, the ribonuclease inhibitor (RI) protein binds to the ribonuclease enzyme and forms a tight complex.

Evaluating the efficacy of recyclable nanostructured adsorbents for rapid removal of methylparaben from aqueous solutions.

In this study, we evaluate the efficiency of two novel nanostructured adsorbents - chitosan-graphitic carbon nitride@magnetite (CS-g-CN@FeO) and graphitic carbon nitride@copper/zinc nanocomposite (g-CN@Cu/Zn NC) - for the rapid removal of methylparaben (MPB) from water. Our characterization methods, aimed at understanding the adsorbents' structures and surface areas, informed our systematic examination of influential parameters including sonication time, adsorbent dosage, initial MPB concentration, and temperature. We applied advanced modeling techniques, such as response surface methodology (RSM), generalized regression neural network (GRNN), and radial basis function neural network (RBFNN), to evaluate the adsorption process.

Engineered exosomes: a promising vehicle in cancer therapy.

During the past few decades, researchers have attempted to discover an effective treatment for cancer. Exosomes are natural nanovesicles released by various cells and play a role in communication between cells. While natural exosomes have high clinical potential, their inherent limitations have prompted researchers to design exosomes with improved therapeutic properties.

Identification of antiproliferative compounds against skin, bone and oral cancer cells.

Objective: This study aimed at the evaluation of anti antiproliferative activity of , , and extracts

Materials And Methods: The extract was taken from the fresh leaves and bulbs of the plants by maceration method in the dark. After separating the solvent, the remaining dry matter was added to the culture medium containing G292, A431 and KB cancer and HGF-1 normal cells. Cytotoxicity tests, as well as cell cycle and apoptosis tests were performed on cells treated with dry substances and untreated cells.

A universal protocol for high-quality DNA and RNA isolation from diverse plant species.

Next-generation sequencing demands high-quality nucleic acid, yet isolating DNA and RNA is often challenging, particularly from plant tissues. Despite advances in developing various kits and reagents, these products are tailored to isolation of nucleic acid from model plant tissues. Here we introduce a universal lysis buffer to separate nucleic acid from various plant species, including recalcitrant plants, to facilitate molecular analyses, such as quantitative PCR (qPCR), transcriptomics, and whole-genome sequencing (WGS).

Effective biosorption of Al ions from drinking water by lignocellulosic biomass rice straw.

High concentration of aluminum (Al) in drinking water is a major intake source of it and can result in serious diseases. Rice straw (RS) as lignocellulosic biomasses has great potential to peak up metal ions from aqueous environment, however, feasibility of Al removal by RS has not been investigated yet. The present study aimed to evaluate the capacity of RS as a novel biosorbent for Al from drinking water.

Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis.

An increasing number of studies have suggested the relationship between single-nucleotide polymorphisms (SNPs) in toll-like receptor (TLR) genes and gastric cancer (GC) susceptibility; however, the available evidence is contradictory. This meta-analysis aimed to comprehensively evaluate whether the SNPs within the TLR family are related to GC development. PubMed, Scopus, and China National Knowledge Infrastructure (CNKI) were systematically searched up to May 2023 to obtain the pertinent publications.

Using heat shock protein (HSP) inducers as an approach to increase the viability of sterlet (Pisces; Acipenseridae; Acipenser ruthenus) cells against environmental diazinon toxicity.

Diazinon (DZN) is an organophosphate pesticide frequently used in agriculture and released into aquatic environments. In this study, sterlet sturgeon cells were exposed to DZN to investigate possible defense mechanisms via HSP induction (HSPi). Liver, kidney, and gill cells of Acipenser ruthenus were isolated and cultured and then treated with HSPi (Pro-Tex®, amygdalin, and a novel pirano-piranazole-based synthesized compound: SZ) in the presence and absence of DZN.

Novel electrospun bead-like AgMoO nanofibers coated on Ni foam for visible light-driven heterogeneous photocatalysis and high-performance supercapacitor electrodes.

Novel AgMoO nanocomposite fibers were designed to enhance the photocatalytic response and supercapacitor performance of MoO grown the sol-gel electrospinning technique. The AgMoO nanocomposite fibers exhibit a high specific surface area of 49.3 m g comprising nanobeads that aggregate in the fibrous structure.

Copper salt of a DABCO-based molten salt: a high-performance catalyst in the one-pot synthesis of 3,4-dihydropyrimidine and polyhydroquinoline derivatives.

In this study, [DABCO](SOH)CuCl as a novel DABCO-based molten salt with dual acidic functionality (Brønsted and Lewis) has been synthesized, characterized and used as a high-performance catalyst in the one-pot synthesis of 3,4-dihydropyrimidine and polyhydroquinoline derivatives. The identification of this catalyst was accomplished by using techniques such as infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermo gravimetric analysis (TGA), field emission scanning electron microscopy (FESEM) and energy dispersive X-ray (EDS) spectroscopy. Excellent efficiency, short reaction times, a simple working method and also use of a recyclable catalyst are the considerable advantages of this process.

Effects of proprioception and core stability training on gait parameters of deaf adolescents: a randomized controlled trial.

The current study aimed to explore the effects of proprioception versus core stability training over 8 weeks on the gait parameters of deaf adolescents. A total of 20 deaf adolescents were randomized into two groups: one group receiving proprioception training (PT, n = 10), another group receiving core stability training (CST, n = 10), and eleven typically developing adolescents assigned into the control group (CON; n = 11). Gait was recorded by two digital cameras; then, using the Kinovea software, the parameters of gait included: gait velocity, cadence, stride length, stride time, stance time, and swing time were calculated in terms of percentages of the walking cycle.

Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5,6-dihydropyrrolo[2″,1″:3',4']pyrazino[1',2':1,5]pyrrolo[2,3-]pyridazine-8(9)-one Derivatives as Potential Cytotoxic Agents.

In the present paper, a facile and efficient synthetic procedure has been applied to obtain dihydrodipyrrolo[1,2-:2',1'-]pyrazine-2,3-dicarboxylates (-), which have subsequently gone through the cyclization in the presence of hydrazine hydrate to afford 12-aryl-11-hydroxy-5,6-dihydropyrrolo[2″,1″:3',4']pyrazino[1',2':1,5]pyrrolo[2,3-]pyridazine-8(9)-ones (-). The molecular structures of these novel compounds were extensively examined through the analysis of spectroscopic data in combination with X-ray crystallography techniques. Following that, the cytotoxic activities of all derivatives against three human cancer cell lines (Panc-1, PC3, and MDA-MB-231) were comprehensively evaluated alongside the assessment on normal human dermal fibroblast (HDF) cells using the MTT assay.

Toxicity of Carboplatin-Niosomal Nanoparticles in a Brain Cancer Cell Line.

Objective: Cancer poses a significant challenge in modern medicine, standing as the primary cause of death in many countries, second only to cardiovascular diseases. Among the various treatments available, carboplatin, a chemotherapy drug, is employed for specific cancer types, including brain carcinoma. The main objective of this investigation is to enhance the therapeutic efficacy of carboplatin by utilizing niosomal nanocarriers.

A novel photoelectrochemical approach with "signal-off" pattern for anodic detection of sunset yellow in food samples based on Bi2WO6/TiO2 NTAs heterostructure nanocomposite.

A new and signal-off photoelectrochemical (PEC) sensing platform utilizing TiO nanotube arrays (NTAs) coated with BiWO nanoparticles (NPs) has been successfully developed for the highly sensitive detection of sunset yellow (SY). The interaction between SY and BiWO NPs leads to substantial steric hindrance, resulting in a noticeable decrease in the photocurrent signal. The proposed PEC sensor demonstrates quantitative detection capabilities for SY across a wide liner range of 10 fM to 100 µM with an ultralow detection limit (LOD) of 0.

Synthesis and electrochemical properties of nanocubes MnSnS for high-performance supercapacitors.

Exploring environment-friendly active material-electrolyte combinations has become increasingly necessary with the rising use of supercapacitors. In this study, the potential of ternary MnSnS on Ni foam as an electrode material was considered. The study investigated the impact of precursors on the morphology of the prepared electrodes utilizing techniques such as X-ray diffraction, energy dispersive X-ray analysis, field-emission scanning electron microscopy, and transmission electron microscopy.

The effect of fatigue on postural control in individuals with multiple sclerosis: a systematic review.

Background: Fatigue is the most disabling symptom for individuals with multiple sclerosis (MS), which can significantly affect postural control (PC) by impairing the ability of the central nervous system to modulate sensory inputs and coordinate motor responses. This systematic review aimed to investigate the effect of fatigue on PC in individuals with MS..

Metformin-modified polyethersulfone magnetic microbeads for effective arsenic removal from apatite soil leachate water.

Arsenic is the hazardous species and still is the global challenge in water treatment. Apatite soil is highly rich in arsenic species, and its mining presents various environmental issues. In this study, novel magnetic microbeads as adsorbent were developed for the elimination of hazardous arsenic ions from apatite soil's aqueous leachate before discharging into environment.

Ontogeny of the digestive enzyme activity of the pikeperch (Sander lucioperca) under culture condition.

The pikeperch (Sander lucioperca) is a species with a high potential for aquaculture and a valuable food with high market acceptance. The aim of the study was to evaluate the functional ontogeny of digestive enzyme of pikeperch from hatching to 45 days-post fertilization, 777 degree-day (DPF, dd) under culture condition. The average total length (TL) of larvae measured at hatching was 3.

Protective effects of HSP Inducer on diazinon-exposed stellate sturgeon (Acipenser stellatus) fry: Insights on HSP70 gene expression, immune response, and enzyme indices.

Aquatic environments face frequent exposure to organophosphate pesticides, such as diazinon, which are frequently utilized in agriculture. The goal of this study was to evaluate the effects of diazinon exposure on fish and to investigate the potential of the HSP inducer (HSPi) in developing a defense mechanism. To achieve this, several factors were analyzed, including the HSP70 gene expression, levels of immunity markers (lysozyme, IgM, and C3), antioxidant status, and the activity of acetylcholine esterase (AChE).

TBX21, the Master regulator of the type 1 immune response, overexpresses in the leukocytes of peripheral blood in patients with late-onset Alzheimer's disease.

Background: The involvement of the peripheral immune system in the etiology of neurodegenerative diseases has recently been emphasized. Genome-wide association studies (GWAS) have recently identified several candidate immune genes linked to development of both Alzheimer's disease (AD) and depression. TBX21 (T-bet) which drives the Th1 immune response, is linked to the major depressive disorder (MDD) phenotype.