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The optimal patch test concentration for ascaridole as a sensitizing component of tea tree oil.
Contact Dermatitis
September 2014
Department of Dermatology, University Medical Center Groningen, University of Groningen 9700RB, Groningen, The Netherlands.
Background: Tea tree oil is used as a natural remedy, but is also a popular ingredient in household and cosmetic products. Oxidation of tea tree oil results in degradation products, such as ascaridole, which may cause allergic contact dermatitis.
Objectives: To identify the optimal patch test concentration for ascaridole, and to investigate the relationship between a positive reaction to ascaridole and a positive reaction to oxidized tea tree oil.