72,123 results match your criteria: "University of Groningen & University Medical Center Groningen[Affiliation]"

Real-World Evidence of the Prevalence of Driver Mutations in Anorectal Melanoma.

Mol Diagn Ther

December 2024

Comprehensive Cancer Center, University of Maastricht, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands.

Introduction: Anorectal melanoma is a rare neoplasm with an aggressive behavior and poor prognosis. Recently, recurrent gene mutations related to anorectal melanoma have been identified in a small series of cases, and this holds promise for targeted therapies, analogous to cutaneous melanoma. The purpose of this study was to analyze testing rates and prevalence of mutations in anorectal melanoma in the Dutch population.

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Membrane-embedded CdaA is required for efficient synthesis of second messenger cyclic di-AMP.

Commun Biol

December 2024

Department of Biochemistry, Groningen Biomolecular Science and Biotechnology Institute, University of Groningen, Nijenborgh 3, Groningen, The Netherlands.

Cyclic di-adenylate monophosphate (cyclic di-AMP) is an important second messenger in microorganisms. Cyclic di-AMP regulates bacterial cell volume and turgor via control of potassium and compatible solute transport but is also involved in many other processes, including the activation of the metazoan innate immune response to bacterial infections. We compare the activity of full-length membrane-embedded CdaA, the enzyme that synthesizes cyclic di-AMP, with the water-soluble catalytic domain CdaA-DAC.

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Inheritance of Material Wealth in a Natural Population.

Ecol Lett

December 2024

Division of Animal Ecology, Department of Ecology and Genetics (IEG), Uppsala University, Uppsala, Sweden.

Evolutionary adaptation occurs when individuals vary in access to fitness-relevant resources and these differences in 'material wealth' are heritable. It is typically assumed that the inheritance of material wealth reflects heritable variation in the phenotypic abilities needed to acquire material wealth. We scrutinise this assumption by investigating additional mechanisms underlying the inheritance of material wealth in collared flycatchers.

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In socially monogamous species, sexual selection not only depends on initial mate choice but also mate switching. To date, studies lack assessment of (1) differences between passive (widowhood) and active (divorce) mate switching, (2) longer term fitness consequences (beyond the season post-divorce) and (3) how age masks reproductive costs and benefits of divorce. We investigated causes and short- and long-term consequences of mate switching and their age dependence using longitudinal data on Seychelles warblers (Acrocephalus sechellensis).

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Normal Anal Sensibility in Patients Born With Anorectal Malformations.

Neurogastroenterol Motil

December 2024

Department of Surgery, Anorectal Physiology Laboratory, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Normal anal sensibility can be present in ARM patients diagnosed with all types of ARM after they have been treated with corrective surgery. Anal sensibility was better in those with a functional IAS. This means that the IAS, present in the distal end of the fistula, should be spared as much as possible to preserve anal sensibility.

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RICTOR variants are associated with neurodevelopmental disorders.

Eur J Hum Genet

December 2024

Laboratoire d'ImmunoRhumatologie Moléculaire, plateforme GENOMAX, INSERM UMR_S 1109, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Institut Thématique Interdisciplinaire TRANSPLANTEX NG, Université de Strasbourg, 4 rue Kirschleger, 67085, Strasbourg, France.

RICTOR is a key component of the mTORC2 signaling complex which is involved in the regulation of cell growth, proliferation and survival. RICTOR is highly expressed in neurons and is necessary for brain development. Here, we report eight unrelated patients presenting with intellectual disability and/or development delay and carrying variants in the RICTOR gene.

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Immune checkpoint inhibitor (ICI) treatment has proven successful for advanced melanoma, but is associated with potentially severe toxicity and high costs. Accurate biomarkers for response are lacking. The present work is the first to investigate the value of deep learning on CT imaging of metastatic lesions for predicting ICI treatment outcomes in advanced melanoma.

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Neurodegeneration in Huntington's disease (HD) is accompanied by the aggregation of fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular pathogenic role has been attributed to the aggregation-prone huntingtin exon 1 (HTTex1), generated by aberrant splicing or proteolysis, and containing the expanded polyglutamine (polyQ) segment. Unlike amyloid fibrils from Parkinson's and Alzheimer's diseases, the atomic-level structure of HTTex1 fibrils has remained unknown, limiting diagnostic and treatment efforts.

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The known unknowns of the Hsp90 chaperone.

Elife

December 2024

Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, Netherlands.

Molecular chaperones are vital proteins that maintain protein homeostasis by assisting in protein folding, activation, degradation, and stress protection. Among them, heat-shock protein 90 (Hsp90) stands out as an essential proteostasis hub in eukaryotes, chaperoning hundreds of 'clients' (substrates). After decades of research, several 'known unknowns' about the molecular function of Hsp90 remain unanswered, hampering rational drug design for the treatment of cancers, neurodegenerative, and other diseases.

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Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours.

Oral Dis

December 2024

Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Objectives: This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD).

Materials And Methods: Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).

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Perfusion Pressures and Weight Loss During Normothermic Machine Perfusion of Human Donor Livers.

Artif Organs

December 2024

Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: Normothermic machine perfusion (NMP) is increasingly used to preserve and assess donor livers prior to transplantation. Due to its success, it is expected that more centers will start using this technology. However, NMP may also cause adverse effects.

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Re-scoping ultradian rhythms in the context of metabolism.

Front Physiol

December 2024

Energy and Sustainability Research Institute Groningen, Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, Netherlands.

Rapid, ultradian biological rhythms are only partly comparable to circadian (24-h) rhythms. Often, the ensuing expectations from this comparison are that 1) ultradian rhythms should be driven by discrete oscillators, 2) they are biochemically buffered, and 3) they must be functionally linked to extrinsic events and cycles. These three expectations are not always met, but perhaps there is an adaptive benefit to ultradian rhythms not meeting these expectations, which sets them functionally apart from circadian rhythms.

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Towards safe and reliable deep learning for lung nodule malignancy estimation using out-of-distribution detection.

Comput Biol Med

December 2024

Diagnostic Imaging Analysis Group, Medical Imaging Department, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, the Netherlands.

Artificial Intelligence (AI) models may fail or suffer from reduced performance when applied to unseen data that differs from the training data distribution, referred to as dataset shift. Automatic detection of out-of-distribution (OOD) data contributes to safe and reliable clinical implementation of AI models. In this study, we propose a recognized OOD detection method that utilizes the Mahalanobis distance (MD) and compare its performance to widely known classical methods.

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Proton-coupled electron transfer (PCET) is a fundamental redox process and has clear advantages in selectively activating challenging C-H bonds in many biological processes. Intrigued by this activation process, we aimed to develop a facile PCET process in cancer cells by modulating proton tunneling. This approach should lead to the design of an alternative photodynamic therapy (PDT) that depletes the mitochondrial electron transport chain (ETC), the key redox regulator in cancer cells under hypoxia.

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Introduction: Programmed death-ligand 1 (PD-L1) is the main predictive biomarker used to identify patients with NSCLC who are eligible for treatment with immune checkpoint inhibitors. Despite its utility, the predictive capacity of PD-L1 is limited, necessitating the exploration of supplementary predictive biomarkers. In this report, we describe the prognostic value of / mutation status for overall survival (OS) in patients with NSCLC treated with first-line immunotherapy or combined chemoimmunotherapy.

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Challenges to Students' Learning and Wellbeing During Placement Abroad: A Qualitative Study Using Rich Pictures.

Perspect Med Educ

December 2024

School of Health Professions Education (SHE), Faculty of Health, Medicine and Life sciences, Maastricht University, Maastricht, The Netherlands.

Introduction: Undergraduate healthcare students on placement abroad can experience challenges that affect their wellbeing, personal and professional development. These challenges may result in students taking a more peripheral role in workplace activities, which negatively impacts learning. We studied .

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Advances and challenges in hydrogel microspheres for biomedical applications.

Biomater Transl

September 2024

Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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Neural correlates of vicarious reward processing and peer victimization experiences in late childhood.

Dev Cogn Neurosci

January 2025

Developmental and Educational Psychology Department, Institute of Psychology, Leiden University, the Netherlands; Leiden Institute for Brain and Cognition, Leiden University, the Netherlands.

This preregistered study examined the neural correlates of vicarious reward processing and subsequent trust behavior in relation to experiences of victimization averaged over two years in late childhood. This study used a sample of children with prospective longitudinal data on peer victimization over the past two years (n = 83, 49.4 % girls, M = 10.

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 - a large-scale dataset of 3D medical shapes for computer vision.

Biomed Tech (Berl)

December 2024

Institute for Artificial Intelligence in Medicine (IKIM), University Hospital Essen (AöR), Essen, Germany.

Objectives: The shape is commonly used to describe the objects. State-of-the-art algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from the growing popularity of ShapeNet (51,300 models) and Princeton ModelNet (127,915 models).

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Higher abdominal fat area associates with lower donor kidney function before and after living kidney donation.

Sci Rep

December 2024

Department of Surgery, Division of Transplant Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Central body fat distribution affects kidney function. Abdominal fat measurements using computed tomography (CT) may prove superior in assessing body composition-related kidney risk in living kidney donors. This retrospective cohort study including 550 kidney donors aimed to determine the association between CT-measured abdominal fat areas and kidney function before and after donor nephrectomy.

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Effects of capsulorhexis size and position on post-surgical IOL alignment.

Sci Rep

December 2024

Visual Optics Lab Antwerp (VOLANTIS), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

In cataract surgery, post-surgical stability of the intraocular lens plays a major role. This study aims to explore how the size and decentration of the capsulorhexis affect intraocular lens decentration and tilt by using numerical methods. Finite element models included zonules, ciliary body, capsular bag, and an IOL with two open-loop haptics were built.

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Motivation: We are witnessing an enormous growth in the amount of molecular profiling (-omics) data. The integration of multi-omics data is challenging. Moreover, human multi-omics data may be privacy-sensitive and can be misused to de-anonymize and (re-)identify individuals.

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Introduction: Women with early bilateral salpingo-oophorectomy (BSO) have greater Alzheimer's disease (AD) risk than women with spontaneous menopause (SM), but the pathway toward this risk is understudied. Considering associative memory deficits may reflect early signs of AD, we studied how BSO affected brain activity underlying associative memory.

Methods: Early midlife women with BSO (with and without 17β-estradiol therapy [ET]) and age-matched controls (AMCs) with intact ovaries completed a face-name associative memory task during functional magnetic resonance imaging.

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