A 2-million-year-old ecosystem in Greenland uncovered by environmental DNA.

Late Pliocene and Early Pleistocene epochs 3.6 to 0.8 million years ago had climates resembling those forecasted under future warming.

Head-to-perineum distance measured transperineally as a predictor of failed midcavity vacuum-assisted delivery.

Background: During the second stage of labor, in case of a need for a fetal extraction at midcavity, the choice of attempting the procedure between operative vaginal delivery and cesarean delivery is difficult. Moreover, guidelines on this subject are not clear.

Objective: This study aimed to identify antenatal and intrapartum parameters associated with a failed midcavity vacuum-assisted delivery and its association with maternal and neonatal adverse outcomes.

Regulating the coordination capacity of ATMP using melamine: facile synthesis of cobalt phosphides as bifunctional electrocatalysts for the ORR and HER.

Due to the complexity of the synthetic process of cobalt phosphides (CoP), ongoing efforts concentrate on simplifying the preparation process of CoP. In this work, amino tris(methylene phosphonic acid) (ATMP, L1) and melamine (MA, L2) are assembled into two-dimensional (2D) organic nanostructures by hydrogen bonding and ionic interactions a supramolecular assembly, which greatly weakens the coordination ability of L1 with Co. As the introduced L2 is rich in carbon and nitrogen, it allows the cobalt-organophosphate complex to be placed under a strongly reducing atmosphere during the high-temperature calcination process to achieve an phosphating purpose.

Nutri-Score: Its Benefits and Limitations in Children's Feeding.

Reducing the burden of noncommunicable diseases (NCDs) is one of the top priorities of public health policies worldwide. One of the recognized means of achieving this objective is to improve the diet quality. The Nutri-Score (N-S) is a [five-color-A, B, C, D, E letters] front-of-pack labeling logo intended to help consumers quickly identify the healthier prepackaged foods within a food category.

Personal exposure to PM oxidative potential and its association to birth outcomes.

Background: Prenatal exposure to fine particulate matter (PM) assessed through its mass concentration has been associated with foetal growth restriction in studies based on outdoor levels. Oxidative potential of PM (OP) is an emerging metric a priori relevant to mechanisms of action of PM on health, with very limited evidence to indicate its role on birth outcomes.

Objectives: We investigated the association of OP with birth outcomes and compared it with that of PM mass concentration.

Efficient Up-Conversion ZnO Co-Doped (Er, Yb) Nanopowders Synthesized via the Sol-Gel Process for Photovoltaic Applications.

In this study, undoped and (Erbium, Ytterbium) co-doped ZnO nanopowders were prepared using the sol-gel method and the supercritical drying of ethyl alcohol. Doping ZnO nanopowders were elaborated with 5 mol% of Er (5 Er: ZnO), 5 mol% of Er and 5 mol% of Yb (5 Er, 5 Yb: ZnO), and 5 mol% of Er and 10 mol% of Yb (5 Er, 10 Yb: ZnO) concentrations. The effects of the Yb concentration on the structural, morphological, photoluminescent, and electrical properties of the ZnO nanopowders were investigated.

Large-scale demonstration of machine learning for the detection of volcanic deformation in Sentinel-1 satellite imagery.

Unlabelled: Radar (SAR) satellites systematically acquire imagery that can be used for volcano monitoring, characterising magmatic systems and potentially forecasting eruptions on a global scale. However, exploiting the large dataset is limited by the need for manual inspection, meaning timely dissemination of information is challenging. Here we automatically process ~ 600,000 images of > 1000 volcanoes acquired by the Sentinel-1 satellite in a 5-year period (2015-2020) and use the dataset to demonstrate the applicability and limitations of machine learning for detecting deformation signals.

Decision-Making in Alzheimer's Disease: The Role of Working Memory and Executive Functions in the Iowa Gambling Task and in Tasks Inspired by Everyday Situations.

Background: Alzheimer's disease (AD) negatively impacts patients' ability to make advantageous decisions, i.e., a core ability contributing to the preservation of autonomy.

Why people should run after positive affective experiences instead of health benefits.

• Promoting health benefits is necessary but insufficient to foster sustained engagement in physical activity (PA). • Our formal decision-making model explains why health benefits hold a weak subjective value. • In this model, expected health benefits are jointly discounted by effort-discounting, delay-discounting, and beliefs distortion.

The first ADC bearing the ferroptosis inducer RSL3 as a payload with conservation of the fragile electrophilic warhead.

The iron-dependent, non-apoptotic cell death, known as ferroptosis is an emerging strategy for the development of anticancer drugs. RSL3 was identified as an activator of ferroptosis through the inhibition of the glutathione peroxidase 4 (GPX4) which plays a crucial role in the cellular lipid oxidative stress. RSL3 is characterized by the presence of an electrophilic chloroacetyl moiety, namely warhead which covalently bonds to the catalytic and nucleophilic selenocysteine residue (Sec46) of GPX4.

Cu(II)-assisted self-assembly of dicyandiamide-derived carbon dots: construction inspired from chemical evolution and its HO sensing application.

In the rapid development of artificial nanomaterials comparable to biological enzymes, we propose herein a novel concept for the construction of functional materials inspired from chemical evolution. To mimic the formation process of the catalytic system for the origin of life, dicyandiamide (DCD) was used as an elemental molecule for the synthesis of an electrocatalyst. DCD was initially condensed with glucose (Glu) to form carbon dots (CDs) a hydrothermal method.

Immobilization of Biantennary N-Glycans Leads to Branch Specific Epitope Recognition by LSECtin.

The molecular recognition features of LSECtin toward asymmetric N-glycans have been scrutinized by NMR and compared to those occurring in glycan microarrays. A pair of positional glycan isomers (LDN3 and LDN6), a nonelongated GlcNAc4Man3 N-glycan (G0), and the minimum binding epitope (the GlcNAcβ1-2Man disaccharide) have been used to shed light on the preferred binding modes under both experimental conditions. Strikingly, both asymmetric LDN3 and LDN6 N-glycans are recognized by LSECtin with similar affinities in solution, in sharp contrast to the results obtained when those glycans are presented on microarrays, where only LDN6 was efficiently recognized by the lectin.

Endovascular Lymphatic Decompression via Thoracic Duct Stent Placement for Refractory Ascites in Patients with Cirrhosis: A Pilot Study.

Purpose: To evaluate the technical and clinical success of endovascular lymphatic decompression via thoracic duct (TD) stent placement in patients with cirrhosis with refractory ascites.

Materials And Methods: Nine patients (6 men and 3 women; median age, 66 [interquartile range {IQR}, 65-68] years; range, 62-78 years) who underwent TD stent placement for refractory ascites with contraindications for liver transplantation and transjugular intrahepatic portosystemic shunt creation were included in this retrospective study. TD stent placement was performed under local anesthesia using retrograde access from the venous system.

Differential metal sensing and metal-dependent degradation of the broad spectrum root metal transporter IRT1.

Iron is an essential micronutrient for plant growth and development. Under low iron conditions, Arabidopsis plants take up soil iron using the root iron transporter IRT1. In addition to iron, IRT1 also transports others divalent metals, including cadmium, which consequently accumulates into plant tissues and enters the food chain.

2D Zn-Porphyrin-Based Co(II)-MOF with 2-Methylimidazole Sitting Axially on the Paddle-Wheel Units: An Efficient Electrochemiluminescence Bioassay for SARS-CoV-2.

High electrocatalytic activity with tunable luminescence is crucial for the development of electrochemiluminescence (ECL) luminophores. In this study, a porphyrin-based heterobimetallic 2D metal organic framework (MOF), [(ZnTCPP)Co(MeIm)] (1), is successfully self-assembled from the zinc(II) tetrakis(4-carboxyphenyl)porphine (ZnTCPP) linker and cobalt(II) ions in the presence of 2-methylimidazole (MeIm) by a facile one-pot reaction in methanol at room temperature. On the basis of the experimental results and the theoretical calculations, the MOF 1 contains paddle-wheel [Co(-CO)] secondary building units (SBUs) axially coordinated by a MeIm ligand, which is very beneficial to the electron transfer between the Co(II) ions and oxygen.

Cellulose Nanofibers from : Preparation and Characterization.

(SM) was investigated as a primary source of cellulose with the aim of discovering resources to generate cellulose nanofibers (CNF). The SM was put through a soda pulping process to purify the cellulose, and then, the fiber was treated with an enzymatic treatment. Then, a twin-screw extruder and/or masuko were utilized to help with fiber delamination during the nanofibrillation process.

Schiff Base Complexes with Covalently Anchored Luminophores: Self-Enhanced Electrochemiluminescence Detection of Neomycin.

A novel electrochemiluminescence (ECL) amplification strategy was established aiming to overcome the inherent shortcomings of the current oxygen (O) coreactant ECL systems. Macrocyclic Schiff base Fe complexes were rationally designed as a novel integrated ECL emitter by iminium linkage between -(4-aminobutyl)--ethylisoluminol (ABEI) and 1,10-phenanthroline-2,9-dicarbaldehyde (PDL) and postmetalation of the macrocyclic Schiff base. Covalently combining luminophore ABEI with a catalytic center endowed the novel ECL emitter with both remarkable redox electrocatalytic properties and significantly enhanced ECL efficiency.

Characterization of a Radical SAM Oxygenase for the Ether Crosslinking in Darobactin Biosynthesis.

Darobactin A is a ribosomally synthesized, post-translationally modified peptide (RiPP) with potent and broad-spectrum anti-Gram-negative antibiotic activity. The structure of darobactin A is characterized by an ether and C-C crosslinking. However, the specific mechanism of the crosslink formation, especially the ether crosslink, remains elusive.

Docking-based long timescale simulation of cell-size protein systems at atomic resolution.

Computational methodologies are increasingly addressing modeling of the whole cell at the molecular level. Proteins and their interactions are the key component of cellular processes. Techniques for modeling protein interactions, thus far, have included protein docking and molecular simulation.

In COVID-19 Health Messaging, Loss Framing Increases Anxiety with Little-to-No Concomitant Benefits: Experimental Evidence from 84 Countries.

The COVID-19 pandemic (and its aftermath) highlights a critical need to communicate health information effectively to the global public. Given that subtle differences in information framing can have meaningful effects on behavior, behavioral science research highlights a pressing question: Is it more effective to frame COVID-19 health messages in terms of potential losses (e.g.

Human Arm Motion Prediction for Collision Avoidance in a Shared Workspace.

Industry 4.0 transforms classical industrial systems into more human-centric and digitized systems. Close human-robot collaboration is becoming more frequent, which means security and efficiency issues need to be carefully considered.

Feasibility of Neovessel Embolization in a Large Animal Model of Tendinopathy: Safety and Efficacy of Various Embolization Agents.

Targeting neovessels in chronic tendinopathies has emerged as a new therapeutic approach and several embolization agents have been reported. The aim of this study was to investigate the feasibility of embolization with different agents in a porcine model of patellar tendinopathy and evaluate their safety and efficacy. Eight 3-month-old male piglets underwent percutaneous injection of collagenase type I to induce patellar tendinopathies ( = 16 tendons).

Leg movements affect speech intensity.

Coordination between speech acoustics and manual gestures has been conceived as "not biologically mandated" (McClave E. 27(1): 69-89, 1998). However, recent work suggests a biomechanical entanglement between the upper limbs and the respiratory-vocal system (Pouw W, de Jonge-Hoekstra D, Harrison SJ, Paxton A, Dixon JA.

From Binary to Ternary Transition-Metal Nitrides: A Boost toward Nitrogen Magneto-Ionics.

Magneto-ionics is an emerging actuation mechanism to control the magnetic properties of materials voltage-driven ion motion. This effect largely relies on the strength and penetration of the induced electric field into the target material, the amount of generated ion transport pathways, and the ionic mobility inside the magnetic media. Optimizing all these factors in a simple way is a huge challenge, although highly desirable for technological applications.

Hypoxic high-intensity interval training in individuals with overweight and obesity.

Combining moderate-intensity exercise training with hypoxic exposure may induce larger improvement in cardiometabolic risk factors and health status compared with normoxic exercise training in obesity. Considering the greater cardiometabolic effects of high-intensity intermittent training (HIIT), we hypothesized that hypoxic high-volume HIIT (H-HIIT) would induce greater improvement in cardiorespiratory fitness and health status despite a lower absolute training workload than normoxic HIIT (N-HIIT) in overweight/obesity. Thirty-one subjects were randomized to an 8-week H-HIIT [10 male and 6 female; age: 51.