16,239 results match your criteria: "University of Granada[Affiliation]"

Movement Behaviors and Bone Biomarkers in Young Pediatric Cancer Survivors: A Cross-Sectional Analysis of the iBoneFIT Project.

Nutrients

November 2024

Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, 18071 Granada, Spain.

Background/objectives: This study aims to investigate the association of movement behaviors with irisin, sclerostin, and bone turnover markers in young pediatric cancer survivors.

Methods: A total of 116 young pediatric cancer survivors (12.1 ± 3.

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Background/objectives: Olive oil is valued for its health benefits, largely due to its bioactive compounds, including hydroxytyrosol (HTyr) and oleuropein (OLE), which have antioxidant, anti-inflammatory, and cardioprotective properties. However, many of these compounds are lost during the production process. This study developed a functional olive oil-derived product using water-in-oil emulsions (W/O) to incorporate commercial extracts rich in HTyr and OLE.

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Impact of Mediterranean Diet Pattern Adherence on the Physical Component of Health-Related Quality of Life in Middle-Aged and Older Active Adults.

Nutrients

November 2024

Health Science and Nutrition Research (HSNR-CTS1118), Department of Nutrition and Food Science, School of Pharmacy, University of Granada, 18071 Granada, Spain.

: The Mediterranean dietary pattern (MedDiet) has numerous health benefits, particularly in preventing chronic diseases and improving well-being. Given the ageing population, understanding its impact on older adults' physical health is essential. This study examines how adherence to the MedDiet influences the physical component (Comp-p) of health-related quality of life (HRQoL) across various age groups, providing insights for tailored dietary interventions.

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Background: Undernutrition impairs linear growth while restoration of nutritional provisions leads to accelerated growth patterns. However, the composition of the nutrition provided is key to facilitating effective catch-up growth without compromising bone quantity, quality, and long-term health.

Methods: We evaluated the role of a whey protein concentrate enriched in bovine milk exosomes (BMEs) in modulating the proliferative properties of human chondrocytes in vitro and studied how these effects might impact bone quantity and quality measured as longitudinal tibia growth, bone mineral content (BMC) and density (BMD), and trabecular micro-CT parameters in stunted rats during catch-up growth.

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This study focuses on the physiological response of lettuce grown on Technosols designed for the remediation of soils polluted by potentially harmful elements (PHEs: As, Cd, Cu, Fe, Pb, and Zn). Lettuce plants were grown in five treatments: recovered (RS) and polluted soil (PS) as controls, and three Technosols (TO, TS, and TV) consisting of 60% PS mixed with 2% iron sludge, 20% marble sludge, and 18% organic wastes (TO: composted olive waste, TS: composted sewage sludge, and TV: vermicompost of garden waste). The main soil properties and PHE solubility were measured, together with physiological parameters related to phytotoxicity in lettuce such as growth, photosynthetic capacity, oxidative stress, and antioxidant defence.

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Collagen-based membrane is the most commonly used biomaterial for guided bone and tissue regeneration; however, its barrier function can be threatened by its rapid degradation pattern, affecting the success of the regeneration process. Differences in the origin and functionalization of the membrane to obtain better properties can alter the degradation rate. The objective of this study was to examine the biodegradation pattern of two commercially available collagen membranes (Jason and Collprotect) manufactured using porcine pericardium or dermis, doped or not with zinc-ions or doxycycline, in a period up to 21 days.

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Background/objectives: The development of therapies targeting unregulated Src signaling through selective kinase inhibition using small-molecule inhibitors presents a significant challenge for the scientific community. Among these inhibitors, pyrazolo[3,4-]pyrimidine heterocycles have emerged as potent agents; however, their clinical application is hindered by low solubility in water. To overcome this limitation, some carrier systems, such as halloysite nanotubes (HNTs), can be used.

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Three-dimensional bioprinting technology has enabled great advances in the treatment of articular cartilage (AC) defects by the biofabrication of biomimetic constructs that restore and/or regenerate damaged tissue. In this sense, the selection of suitable cells and biomaterials to bioprint constructs that mimic the architecture, composition, and functionality of the natural extracellular matrix (ECM) of the native tissue is crucial. In the present study, a novel cartilage-like biomimetic hybrid construct (CBC) was developed by 3D bioprinting to facilitate and promote AC regeneration.

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Article Synopsis
  • - The study involved screening around 2.5 million compounds from various databases to identify potential inhibitors of a chimeric tyrosine kinase, focusing on their antiproliferative activity and pharmacokinetic properties.
  • - Nine compounds were identified as having desirable ADME/Tox properties, with their biological activity predictions indicating that they could be effective protein kinase inhibitors, showing varied activity percentages.
  • - Two promising compounds, LMQC01 and LMQC04, demonstrated strong molecular docking results and stability in simulations, suggesting they have good potential for inhibiting the enzyme function of the target kinase and are easy to synthesize.
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The Role of Visual Performance in Fine Motor Skills.

Life (Basel)

October 2024

Laboratory of Vision Sciences and Applications, Department of Optics, Faculty of Sciences, University of Granada, Avenida Fuentenueva s/n, 18071 Granada, Spain.

The aim of this study was to analyse the relationship between fine motor skills (FMSs) and visual performance. Thirty young participants with normal binocular vision performed five fine motor tasks: Purdue, Grooved, and O'Connor pegboards, a needle threading task, and a water pouring task, which were characterised by the time taken to complete the task, the number of pegs inserted, the error made in pouring the water, and the volume spilled. To evaluate visual performance, near visual acuity, near contrast sensitivity (CS), and disability glare were assessed.

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Article Synopsis
  • Recent developments in understanding AD have highlighted the OX40 receptor's role, leading to new treatments that block the OX40 ligand, which have shown considerable improvement in patients with moderate to severe AD.
  • A thorough review of anti-OX40 treatments suggests they could be a promising option for AD management, but further studies are necessary to evaluate their long-term effectiveness in treating the disease.
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: This review synthesizes the role of () and () in modulating immune responses through citrullination and assesses its impact on periodontitis and systemic conditions. A systematic review was conducted on preclinical and clinical studies focusing on and -induced citrullination and its effects on immune responses, particularly inflammatory pathways, and systemic diseases. The search included PubMed, Scopus, Google Scholar, Web of Science, and gray literature.

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Simvastatin Efficacy on Endodontic Biofilms: An In Vitro Study.

Materials (Basel)

November 2024

Department of Stomatology, School of Dentistry, University of Granada, 18071 Granada, Spain.

Unlabelled: The outcome of endodontic therapy is directly related to the control of infection. The aim of the study was to evaluate in vitro the efficacy of Simvastatin (SIM) and diclofenac (DC) solutions on endodontic biofilms.

Methods: Mature biofilms were grown on dentin specimens and put in contact with the solutions to determine their antibiofilm activity.

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The aim of this study was to evaluate the psychometric properties of SAVE-6 in the medical student population and assess its gender invariance. The sample consisted of 320 medical students aged 18-23 years (153 men and 167 women) who completed an anonymous online questionnaire. Data collection took place in June 2024.

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Article Synopsis
  • Bisphenol A (BPA) and its analogs (BPF, BPS, BPAF) negatively affect bone tissue by disrupting key cellular processes, particularly in human osteoblasts.
  • The study focused on the impact of these chemicals on growth factors like VEGF and TGF-β1, assessing gene expression changes after exposing osteoblasts to various concentrations of these compounds.
  • Results showed that most bisphenols downregulated RANKL, OPG, TGF-β1, and their receptors, suggesting they could lead to harmful molecular changes that affect bone health despite BPAF prompting some OPG expression.
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Explainable Machine Learning Models Using Robust Cancer Biomarkers Identification from Paired Differential Gene Expression.

Int J Mol Sci

November 2024

Department of Computer Science and Artificial Intelligence, Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI), University of Granada, 18071 Granada, Spain.

In oncology, there is a critical need for robust biomarkers that can be easily translated into the clinic. We introduce a novel approach using paired differential gene expression analysis for biological feature selection in machine learning models, enhancing robustness and interpretability while accounting for patient variability. This method compares primary tumor tissue with the same patient's healthy tissue, improving gene selection by eliminating individual-specific artifacts.

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The interplay between socio-psychological factors and biological systems is pivotal in defining human health and disease, particularly in chronic non-communicable diseases. Recent advancements in psychoneuroimmunology and mitochondrial psychobiology have emphasized the significance of psychological factors as critical determinants of disease onset, progression, recurrence, and severity. These insights align with evolutionary biology, psychology, and psychiatry, highlighting the inherent social nature of humans.

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The Effects of Post-Warm-Up Active and Passive Rest Periods on a Vigilance Task in Karate Athletes.

Behav Sci (Basel)

November 2024

Escola Superior de Desporto e Lazer, Instituto Politécnico de Viana do Castelo, Rua Escola Industrial e Comercial de Nun'Álvares, 4900-347 Viana do Castelo, Portugal.

This study aimed to analyze how active versus passive rest periods after a warm-up influence performance in psychomotor vigilance tasks (PVT). Twenty amateur karate athletes participated in a randomized cross-over study consisting of two sessions with either a 20 min active rest involving kata techniques or passive rest. PVT was administered before and after these conditions to assess the changes in reaction time.

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The intrauterine period is a time of high sensitivity in the development of the embryo and the fetus. Therefore, low levels of maternal stress are closely associated with healthy brain development in the neonatal and early childhood periods. There is increasing evidence linking natural disasters as prenatal maternal stress (PNMS) to neurodevelopmental disorders (including subclinical manifestations).

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Probiotics have awakened a great interest in the scientific community for their potential beneficial effects on health. Although only allowed by the European Food Safety Agency as a nutrition declaration associated with the improvement of lactose digestion, recent in vitro and in vivo studies have demonstrated their varied beneficial effect for the improvement of certain pathologies. However, probiotics face stability and viability challenges, which make their delivery difficult in sufficient quantities for these effects to be observed.

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Interfacial behaviour of human bile and its substitution for in vitro lipolysis studies.

Food Res Int

December 2024

Department of Biotechnology and Microbiology, Faculty of Chemistry, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, Poland. Electronic address:

This study examined the interfacial evolution of individual bile salts (BSs) and their blends with phosphatidylcholine (BS/PC) to simulate the complex behaviour of human bile (HB) during lipolysis at the triglyceride/water interface. Using adsorption and desorption cycles, mimicking exposure to small intestinal fluids, we demonstrate that the interfacial behaviour of real HB can be replicated using simple mixtures of BSs and PC. Interfacial tension (IFT) measurements after lipolysis and desorption showed no significant differences (P > 0.

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Reply to comments on "Is the sustainability of exposure to non-ionizing electromagnetic radiation possible?".

Med Clin (Barc)

November 2024

Research Support Unit, Biosanitary Institute of Granada (ibs.GRANADA), University Hospital Complex of Granada, Granada, Spain; Department of Radiology and Physical Medicine, School of Medicine, University of Granada, Granada, Spain; Biopathology and Regenerative Medicine Institute (IBIMER), University of Granada, Granada, Spain. Electronic address:

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This study explores and compares the motivations behind badminton participation among older adult players from Taiwan and the United States (U.S.), with a specific focus on cultural and gender differences.

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