Tideglusib enhances ALP activity and upregulates RANKL expression in Osteoblast-macrophage Co-cultures within a 3D collagen scaffold.

Objectives: Tideglusib (Tx) is known for its osteogenic potential, yet its effects on the interplay between osteoblasts and M1 macrophages remain underexplored. This in vitro study aimed to isolate and evaluate both the individual and combined roles of M1 macrophages and osteoblasts in macrophage differentiation and osteoblast function, specifically focusing on how these interactions influence protein expression of osteogenesis and osteoclastogenesis in the presence or absence of Tx.

Methods: Osteoblast and macrophage cells were co-cultured in direct contact for 24 and 48 h, with or without the presence of Tx.

Highly branched cyclic dextrin supplementation and resistance training: A randomized double-blinded crossover trial examining mechanical, metabolic, and perceptual responses.

Background & Aims: The aim of this study was to investigate the potential ergogenic effects of intra-session supplementation of highly branched cyclic dextrin (HBCD) on mechanical (number of repetitions completed and repetition velocity), metabolic (lactate concentration), and perceptual (gastrointestinal complaints and ratings of perceived exertion [RPE]) responses to resistance training.

Methods: This study used a randomized, double-blinded, placebo-controlled crossover study design. Thirty physically active individuals (15 men and 15 women) completed two experimental sessions that only differed in the supplement condition (placebo or HBCD).

Follow up of patients with chronic pain using a mobile phone app with a support center: unicenter prospective study.

Background: Chronic pain is one of the most common diseases in the world and requires a multidisciplinary treatment approach. Spinal cord stimulation is a possible treatment option, but these patients require close follow-up, which is not always feasible. Introduction: eHealth apps also offer the possibility of closer patient follow-up, although adherence tends to decrease over time, dropping to around 60%.

Phylogenomics of neglected flagellated protists supports a revised eukaryotic tree of life.

Eukaryotes evolved from prokaryotic predecessors in the early Proterozoic and radiated from their already complex last common ancestor, diversifying into several supergroups with unresolved deep evolutionary connections. They evolved extremely diverse lifestyles, playing crucial roles in the carbon cycle. Heterotrophic flagellates are arguably the most diverse eukaryotes and often occupy basal positions in phylogenetic trees.

Mindfulness-Based Stress Reduction Program for reducing anxiety and depression in hospital staff during a pandemic: A randomized controlled trial.

Hospital staff have experienced an increase in psychopathological symptoms such as anxiety or depression during the COVID-19 pandemic. Thus, the aims of the present research were, firstly, to study the effectiveness of the Mindfulness-Based Stress Reduction Program in reducing psychopathological symptoms in hospital staff during the COVID-19 pandemic, as well as, its effectiveness in increasing mindfulness-related skills, self-compassion, body awareness, and reducing stress levels. This parallel randomized controlled trial consisted of 97 hospital workers who were divided into two groups: the experimental group (n = 54) and the control group (n = 44).

High-intensity interval training effects on people with multiple sclerosis; a systematic review and meta-analyses for exercise capacity and fatigue.

Objective: This study was to examine the effects of high-intensity interval training (HIIT) interventions on exercise capacity and fatigue in people with MS.

Design: We performed a systematic review and meta-analysis. PubMed/Medline, Web of Science, Scopus and Google Scholar databases were systematically searched from inception to January 2024.

High-intensity physiological activation disrupts the neural signatures of conflict processing.

Physiological activation fluctuates throughout the day. Previous studies have shown that during periods of reduced activation, cognitive control remains resilient due to neural compensatory mechanisms. In this study, we investigate the effects of high physiological activation on both behavioural and neural markers of cognitive control.

Phase I-IIa clinical trial to evaluate the safety, feasibility and efficacy of the use of a palate mucosa generated by tissue engineering for the treatment of children with cleft palate: the BIOCLEFT study protocol.

Introduction: The current gold standard treatment for patients with orofacial clefts is surgical repair of the palatal defect (uranostaphylorrhaphy), which is associated with growth defects and hypoplasia of the maxillofacial structures. This trial aims to evaluate the potential of a bioengineered artificial palate mucosa, created through tissue engineering with autologous stromal and epithelial cells and nanostructured fibrin-agarose biomaterials, to enhance treatment outcomes for patients with unilateral cleft lip and palate.

Methods And Analysis: This phase I-IIa clinical trial aims to evaluate the feasibility and biosafety of a procedure involving grafting bioartificial palate mucosa onto the areas of denudated bone in patients undergoing uranostaphylorrhaphy.

Higher plasma levels of endocannabinoids and analogues are correlated with a worse cardiometabolic profile in middle-aged adults.

The increase in age-related comorbidities, such as cardiometabolic diseases, has become a global health priority. There is a growing need to find new parameters capable of improving the detection of cardiometabolic risk factors, and circulating endocannabinoids (eCBs) are a promising tool in this context. Here, we aimed to investigate the relationship between plasma levels of eCBs and their analogues with body composition and cardiometabolic risk factors in middle-aged adults.

Age- and sex-specific reference percentile curves for accelerometry-measured physical activity in healthy European children and adolescents.

Unlabelled: Physical activity measured by accelerometry (PA-accelerometry) is used as an indicator of physical capacity in chronic diseases. Currently, only fragmented age ranges of reference percentile curves are available for European children and adolescents. This study aimed to provide age- and sex-specific percentiles for physical activity measured by hip-worn accelerometry derived throughout the full age range of European children and adolescents.

In-hospital and delayed mortality in patients with upper gastrointestinal bleeding on antithrombotic treatment: effects of withdrawal and resuming.

Background: Antithrombotic drugs pose a dual challenge to acute upper gastrointestinal bleeding, with associated risks of bleeding complications and thromboembolic events upon withdrawal. We aimed to determine the impact of antithrombotic medications on in-hospital and delayed outcomes and whether suspension and resumption influenced delayed mortality.

Methods: This study was a prospective registry analysis of patients between 2013-2021.

Intercalation of the anticancer drug lenalidomide into montmorillonite for bioavailability improvement: a computational study.

Context: Lenalidomide (LEN) is used for the treatment of myeloma blood cancer disease. It has become one of the most efficient drugs to halt this disease. LEN is a low-soluble drug in aqueous media.

FlowerMate: Multidimensional reciprocity and inaccuracy indices for style-polymorphic plant populations.

Premise: Heterostyly in plants promotes pollen transfer between floral morphs, because female and male sex organs are located at roughly reciprocal heights within the flowers of each morph. Reciprocity indices, which assess the one-dimensional variation in the height of sex organs, are used to define the phenotypic structure of heterostyly in plant populations and to make inferences about selection. Other reciprocal stylar polymorphisms (e.

Socio-Economic Inequalities in Beliefs About Cancer and its Causes: Evidence From two Population Surveys.

Objective: People's beliefs about cancer can affect the actions they take to prevent and detect the disease. We investigated socio-economic inequalities in beliefs about cancer and its causes in the general population.

Methods: We analyzed data from the representative probabilistic Spanish Oncobarometer survey (N = 4769, 2020) and the non-probabilistic weight-corrected Spanish Cancer Awareness Survey (N = 1029, 2022).

Grief responses during the COVID-19 pandemic: A qualitative study in Spain.

Introduction: The recent COVID-19 pandemic led to a rise in the number of people bereaved by the death of a loved one. There are many pandemic-related stressors that may have further complicated grief in these people. The aim of this research was to conduct an in-depth the experience of illness and death during the pandemic, as well as obstacles to and factors facilitating grief in people who had lost a loved one during this period, whether due to COVID-19 or to natural or sudden causes.