Regioselective halogenation of -aryl amides and ureas oxidative halodeboronation: harnessing boron reactivity for efficient C-halogen bond installation.

The installation of the C-halogen bond at the position of -aryl amides and ureas represents a tool to prepare motifs that are ubiquitous in biologically active compounds. To construct such prevalent bonds, most methods require the use of precious metals and a multistep process. Here we report a novel protocol for the long-standing challenge of regioselective halogenation of -aryl amides and ureas using an oxidative halodeboronation.