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BMC Gastroenterol
January 2012
Department of Gastroenterology, Endocrinology and Metabolism, University of Giessen und Marburg GmbH, Site Marburg, Baldingerstrasse, 35037 Marburg, Germany.
Background: Enteric glia cells (EGC) play an important role in the maintenance of intestinal mucosa integrity. During the course of acute Crohn's disease (CD), mucosal EGC progressively undergo apoptosis, though the mechanisms are largely unknown. We investigated the role of Glial-derived neurotrophic factor (GDNF) in the regulation of EGC apoptosis.
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