33 results match your criteria: "University of Genova Genova[Affiliation]"

Article Synopsis
  • Marine top predator populations, including a third of chondrichthyans, are declining, with the Mediterranean blue shark classified as critically endangered due to limited data on their population structure and connectivity.
  • A genetic study on 203 blue shark specimens identified subtle genetic differences both within the Mediterranean and between it and the Northeast Atlantic, suggesting demographic independence of Western and Eastern populations.
  • Despite limited reproductive interactions, the slight genetic differentiation hints at a recent shared history, indicating that Mediterranean blue sharks may act as a metapopulation influenced by local demographic changes and poor regulation of fishing practices.
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The Dolichens project provides the first dynamic inventory of the lichens of the Dolomites (Eastern Alps, Italy). Occurrence records were retrieved from published and grey literature, reviewed herbaria, unpublished records collected by the authors, and new sampling campaigns, covering a period from 1820 to 2022. Currently, the dataset contains 56,251 records, referring to 1,719 infrageneric taxa, reported from 1820 to 2022, from hilly to nival belts, and corresponding to about half of the species known for the whole Alpine chain.

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The synthesis strategy and magnetic characterisation of two systems consisting of nanoparticles with core/shell morphology are presented: an assembly of hard/soft nanoparticles with cores consisting of magnetically hard cobalt ferrite covered by a magnetically soft nickel ferrite shell, and the inverse system of almost the same size and shape. We have successfully designed these nanoparticle systems by gradually varying the magnetic anisotropy resulting in this way in the modulation of the magnetic dipolar interactions between particles. Both nanoparticle systems exhibit high saturation magnetisation and display superparamagnetic behaviour at room temperature.

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Characterizing the pressure and temperature () histories of eclogite facies rocks is of key importance for unravelling subduction zone processes at all scales. Accurate estimates provide constraints on tectonic and geochemical processes affecting subduction dynamics and help in interpreting the geophysical images of present-day converging plates. Conventional equilibrium geothermobarometers are challenged in ultra high pressure (UHP) metamorphic terranes, as minerals may undergo re-equilibration along their exhumation path.

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Through two studies ( = 602) conducted in Italy between February and March 2020, we examined the impact of the COVID-19 emergency on biologization-a form of dehumanization that involves the perception of others as contagious entities-and outgroup prejudice. Overall, results showed that higher emergency perception was associated with greater biologization toward the groups most affected by the virus, namely the Chinese outgroup and the Italian ingroup. In turn, biologization toward the outgroup increased prejudice against that group.

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The lichens of the Majella National Park (Central Italy): an annotated checklist.

MycoKeys

March 2021

BIOME Lab, Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum - University of Bologna, Via Irnerio 42, 40126, Bologna, Italy University of Bologna Bologna Italy.

The botanical exploration of the Majella National Park has a long tradition dating back to the eighteenth century. However, the lichen biota of this area is still poorly investigated. To provide a baseline for future investigations, in this annotated checklist, we summarised all available information on the occurrence of lichens in the Majella National Park, retrieved from previous literature, herbarium material and original data produced by recent research.

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Small-World Propensity Reveals the Frequency Specificity of Resting State Networks.

IEEE Open J Eng Med Biol

February 2020

Rehab TechnologiesIstituto Italiano di Tecnologia 16163 Genova Italy.

Functional connectivity (FC) is an important indicator of the brain's state in different conditions, such as rest/task or health/pathology. Here we used high-density electroencephalography coupled to source reconstruction to assess frequency-specific changes of FC during resting state. Specifically, we computed the Small-World Propensity (SWP) index to characterize network small-world architecture across frequencies.

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Objective: Clinical and genetic predictors of response to antiepileptic drugs (AEDs) are largely unknown. We examined predictors of lacosamide response in a real-world clinical setting.

Methods: We tested the association of clinical predictors with treatment response using regression modeling in a cohort of people with refractory epilepsy.

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Blood neurofilament light as a potential endpoint in Phase 2 studies in MS.

Ann Clin Transl Neurol

June 2019

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering University Hospital Basel, University of Basel Basel Switzerland.

Objectives: To assess whether neurofilament light chain (NfL) could serve as an informative endpoint in Phase 2 studies in patients with relapsing-remitting multiple sclerosis (RRMS) and estimate the sample size requirements with NfL as the primary endpoint.

Methods: Using data from the Phase 3 FREEDOMS study, we evaluated correlation of NfL at Month 6 with 2-year outcomes: relapses, confirmed disability worsening (CDW), new or enlarging T2 lesions (active lesions), and brain volume loss (BVL). We compared the proportion of treatment effect (PTE) on 2-year relapses and BVL explained by 6-month log-transformed NfL levels with the PTE explained by the number of active lesions over 6 months.

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The main focus of cardio-oncology has been the prevention and treatment of the cardiac toxicity of chemotherapy and radiotherapy. Furthermore, several targeted therapies have been associated with unexpected cardiotoxic side-effects. Recently, epidemiological studies reported a higher incidence of cancer in patients with heart failure (HF) compared with individuals without HF.

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Objectives: To evaluate long-term outcomes of patients subjected to corporoplasty, plaque incision and excision, and autologous dermal grafting, with at least 15 years of follow-up. METHODS: The charts of consecutive patients with a penile curvature and a minimum of 15 years follow up were retrospectively reviewed. The patients underwent corporoplasty and penile straightening with autologous dermal grafting, harvested at the level of the anterior-superior iliac spine.

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Objective: We present two rare cases ofbladder xanthomata associated with transitional cell carcinoma.

Method And Results: Cases description and selectionof related pictures. Review of the existing literature.

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Bicycle riding has multiple beneficial cardiovascular effects; however, it is a well-documented source of significant urologic injuries. Priapism is a rare condition in children, and occurs primarily because of congenital hematologic diseases or adverse drug reactions. A pediatric clinical case and literature review of a high-flow priapism secondary to cycling trauma is described here to highlight their etiopathologic correlation.

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An FPGA Platform for Real-Time Simulation of Spiking Neuronal Networks.

Front Neurosci

February 2017

EOLab - Microelectronics and Bioengineering Lab, Department of Electrical and Electronic Engineering, University of Cagliari Cagliari, Italy.

In the last years, the idea to dynamically interface biological neurons with artificial ones has become more and more urgent. The reason is essentially due to the design of innovative neuroprostheses where biological cell assemblies of the brain can be substituted by artificial ones. For closed-loop experiments with biological neuronal networks interfaced with modeled networks, several technological challenges need to be faced, from the low-level interfacing between the living tissue and the computational model to the implementation of the latter in a suitable form for real-time processing.

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Article Synopsis
  • Cancer stem cells (CSCs) play a crucial role in tumor resistance to therapy in glioblastoma (GBM), making targeted therapies against CSCs a key research focus.
  • The study investigates givinostat (GVS), a histone deacetylase inhibitor, showing it significantly reduces viability and self-renewal in GBM CSCs without harming differentiated GBM cells or normal stem cells.
  • The findings suggest that GVS triggers programmed cell death and autophagy, with autophagy acting as a survival mechanism for GBM CSCs; thus, inhibiting autophagy could enhance GVS effectiveness against CSCs.
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Music Ensemble as a Resilient System. Managing the Unexpected through Group Interaction.

Front Psychol

October 2016

Neuroscience of Emotion and Affective Dynamics Lab, Swiss Center for Affective Sciences, Faculty of Psychology and Educational Sciences, University of Geneva Geneva, Switzerland.

The present contribution provides readers from diverse fields of psychology with a new and comprehensive model for the understanding of the characteristics of music ensembles. The model is based on a novel heuristic approach whose key construct is resilience, intended here as the ability of a system to adapt to external perturbations and anticipate future events. The paper clarifies the specificity of music ensemble as an original social and creative activity, and how some mechanisms, at an individual (cognitive) and group (coordination) level, are enacted in a particular way that endows these groups with exceptional capacity for resilience.

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Interfacing Cultured Neurons to Microtransducers Arrays: A Review of the Neuro-Electronic Junction Models.

Front Neurosci

July 2016

Neuroengineering and Bio-nanoTechnology Laboratory, Department of Informatics, Bioengineering, Robotics, System Engineering, University of Genova Genova, Italy.

Microtransducer arrays, both metal microelectrodes and silicon-based devices, are widely used as neural interfaces to measure, extracellularly, the electrophysiological activity of excitable cells. Starting from the pioneering works at the beginning of the 70's, improvements in manufacture methods, materials, and geometrical shape have been made. Nowadays, these devices are routinely used in different experimental conditions (both in vivo and in vitro), and for several applications ranging from basic research in neuroscience to more biomedical oriented applications.

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Cognitive rehabilitation in multiple sclerosis (MS) has been reported to induce neuropsychological improvements, but the persistence of these effects has been scarcely investigated over long follow ups. Here, the results of a multicenter randomized clinical trial are reported, in which the efficacy of 15 week domain specific cognitive training was evaluated at 2 years follow up in 41 patients. Included patients were randomly assigned either to domain specific cognitive rehabilitation, or to aspecific psychological intervention.

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Previous research has suggested that personality traits of the Five Factor Model play a role in worker's response to workload. The aim of this study was to investigate the association of personality traits of first responders with their perceived workload in real-life tasks. A flying column of 269 police officers completed a measure of subjective workload (NASA-Task Load Index) after intervention tasks in a major public event.

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Functional connectivity in in vitro neuronal assemblies.

Front Neural Circuits

July 2016

Department of Informatics, Bioengineering, Robotics and System Engineering, University of Genova Genova, Italy.

Complex network topologies represent the necessary substrate to support complex brain functions. In this work, we reviewed in vitro neuronal networks coupled to Micro-Electrode Arrays (MEAs) as biological substrate. Networks of dissociated neurons developing in vitro and coupled to MEAs, represent a valid experimental model for studying the mechanisms governing the formation, organization and conservation of neuronal cell assemblies.

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Responsiveness in DoC and individual variability.

Front Hum Neurosci

June 2015

Department of Neuroscience, Ophthalmology and Genetics, University of Genova Genova, Italy ; Institute S. Anna - Research in Advanced Neuro-Rehabilitation Crotone, Italy ; Department of Psychiatry, State University of New York at Stony Brook Stony Brook, NY, USA.

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