Estrogen Receptor Βeta Stimulation as a Possible Novel Therapeutic Target for Cutaneous T-Cell Lymphoma.

Cutaneous T-cell lymphomas (CTCL), including mycosis fungoides (MF) and Sézary syndrome (SS), are rare hematological malignancies with limited curative treatment options. Despite early-stage responsiveness, these malignancies often relapse in advanced stages, highlighting the need for novel, durable therapies. As other non-Hodgkin lymphoma (NHL) MF and SS have a greater incidence rate in males than females.