Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment.

The advantages of a treatment modality that combines two or more therapeutic agents with different mechanisms of action encourage the study of hybrid functional compounds for pharmacological applications. Molecular hybridization, resulting from a covalent combination of two or more pharmacophore units, has emerged as a promising approach to overcome several issues and has also been explored for the design of new drugs for COVID-19 treatment. In this review, we presented an overview of small-molecule hybrids from both natural products and synthetic sources reported in the literature to date with potential antiviral -SARS-CoV-2 activity.

Application of Artificial Intelligence Models to Predict the Onset or Recurrence of Neovascular Age-Related Macular Degeneration.

Neovascular age-related macular degeneration (nAMD) is one of the major causes of vision impairment that affect millions of people worldwide. Early detection of nAMD is crucial because, if untreated, it can lead to blindness. Software and algorithms that utilize artificial intelligence (AI) have become valuable tools for early detection, assisting doctors in diagnosing and facilitating differential diagnosis.

The EUPEMEN (EUropean PErioperative MEdical Networking) Protocol for Acute Appendicitis: Recommendations for Perioperative Care.

Acute appendicitis (AA) is one of the most common causes of emergency department visits due to acute abdominal pain, with a lifetime risk of 7-8%. Managing AA presents significant challenges, particularly among vulnerable patient groups, due to its association with substantial morbidity and mortality. : The EUPEMEN (European PErioperative MEdical Networking) project aims to optimize perioperative care for AA by developing multidisciplinary guidelines that integrate theoretical knowledge and clinical expertise from five European countries.

Effectiveness and Personalized Approaches in the Correction of Gummy Smile: A Systematic Review of Orthodontic and Surgical Treatments.

This systematic review seeks to assess the effectiveness of different orthodontic and combined orthodontic-surgical approaches for correcting gummy smile, with a focus on treatment efficacy, duration, and the potential for integrating various techniques. The objective is to offer evidence-based recommendations for the optimal management of gummy smile. A thorough search of the literature was conducted in the PubMed, Cochrane Library, Scopus, and Web of Science databases, covering publications from 1 January 1982 to 4 November 2024.

Effect of Dehydrogenation and Heat Treatments on the Microstructure and Tribological Behavior of Electroless Ni-P Nanocomposite Coatings.

High phosphorus Ni-P coatings, both unreinforced and modified by the addition of alumina (AlO) and zirconia (ZrO) nanoparticles, were manufactured by electroless deposition technique and heat-treated with different temperature and duration schedules. The effect of dehydrogenation (200 °C for 2 h) and its combination with crystallization heat treatment was studied in terms of microstructural changes and wear resistance. The amorphous structure of the coatings was not altered by the introduction of both AlO and ZrO nanoparticles, and the addition of 1.

Paracetamol Use and COVID-19 Clinical Outcomes: A Meta-Analysis.

Background: During the COVID-19 pandemic, paracetamol was widely recommended in different clinical settings, and sometimes advised over non-steroidal anti-inflammatory drugs (NSAIDs). These recommendations sparked a strong debate, with reports suggesting either potential benefits or harms for the individuals infected with SARS-CoV-2. As no systematic review is available, we performed a meta-analysis to estimate the impact of paracetamol on COVID-19 clinical outcomes compared to a placebo, no use, or NSAIDs.

Serological and Molecular Investigation of Infectious Laryngotracheitis Virus in Chickens from Robe Town, Southeastern Ethiopia.

Infectious laryngotracheitis virus (ILTV) is responsible for avian infectious laryngotracheitis (ILT), a highly contagious acute respiratory disease affecting chickens. However, there is limited information on ILTV and its distribution in Ethiopia, particularly in the southeastern region. The aim of this study was to establish the serological prevalence and molecular evidence in commercial and backyard chickens from Robe town, Southeastern Ethiopia.

Emerging Mechanisms of Physical Exercise Benefits in Adjuvant and Neoadjuvant Cancer Immunotherapy.

The primary factors that can be modified in one's lifestyle are the most influential determinants and significant preventable causes of various types of cancer. Exercise has demonstrated numerous advantages in preventing cancer and aiding in its treatment. However, the precise mechanisms behind these effects are still not fully understood.

The Otoacoustic Emissions in the Universal Neonatal Hearing Screening: An Update on the European Data (2004 to 2024).

The reported data on European universal neonatal hearing screening (UNHS) practices tend to be scarce, despite the fact that the European Union project, EUScreen, collected unofficial data from 38 collaborating European institutions. The objectives of this systematic review were as follows: (a) to identify the most recent (in a 20-year span) literature information about UNHS programs in Europe and (b) to provide data on the procedures used to assess the population, the intervention policies, and on the estimated prevalence of congenital hearing loss with emphasis on the bilateral hearing loss cases. Queries were conducted via the Pubmed, Scopus and Google Scholar databases for the time period of 2004-2024.

Fake-News Attitude Evaluation in Terms of Visual Attention and Personality Traits: A Preliminary Study for Mitigating the Cognitive Warfare.

Although the Internet grants access to a large amount of information, it is crucial to verify its reliability before relying on it. False information is a dangerous medium that poses a considerable threat, as it impacts individuals' perceptions and information processing, eventually shaping people's behaviors. Misinformation can be weaponized, especially in cross-border conflicts, where it can be used as a means to erode social cohesion by manipulating public opinion and exacerbate tensions between nations.

The Role of Eye Movements in the Process of Silicone Oil Emulsification After Vitreoretinal Surgery.

Emulsification is a feared and common complication of the use of silicone oil (SO) as tamponade fluid after vitrectomy as it potentially associated with significant risks to ocular health, including elevated intraocular pressure (IOP), glaucoma, corneal and retinal changes. The aim of this study was to investigate the role and interplay of physical factors on the formation of SO emulsion. Experiments were performed in a model of the vitreous chamber with a realistic shape, filled with SO and an aqueous solution containing different concentrations of albumin, an endogenous protein known to modify the interfacial properties between SO and aqueous solutions.

Aortic Dimension in Elite Athletes: Updated Systematic Review and Meta-Analysis.

Aims: To assess the presence and the extent of an "aortic remodeling" in elite athletes.

Methods: A systematic review and meta-analysis of literature were conducted for studies (1981-2024) reporting echocardiographic aortic diameters of elite athletes compared to non-athlete healthy controls. Among the 5,494 studies retrieved, 21 (9,464 elite athletes vs.

Care pathways for individuals with post-anoxic disorder of consciousness (CaPIADoC): an inter-society Consensus Conference.

Background: Accurate recognition of consciousness level and detection of neurological complications since the intensive care unit are crucial for an appropriate prognostication and tailored treatment in patients with post-anoxic disorder of consciousness (DoC).

Objective: The present inter-society Consensus Conference aimed at addressing current debates on diagnostic and prognostic procedures.

Methods: Twelve working groups involving 22 multidisciplinary professionals (membership of 9 Scientific Societies and 2 patients' family Associations) conducted a systematic literature review focused on 12 questions addressing diagnosis (n = 5) and prognosis (n = 7).

Metaphors and the Invention of Writing.

The foundation of ancient, invented writing systems lies in the predominant iconicity of their sign shapes. However, these shapes are often used not for their referential meaning but in a metaphorical way, whereby one entity stands for another. Metaphor, including its subcategories pars pro toto and metonymy, plays a crucial role in the formation of the earliest pristine invented scripts, yet this mechanism has been understudied from a cognitive, contextual, and comparative perspective.

Histopathological outcomes of transanal, robotic, open, and laparoscopic surgery for rectal cancer resection. A Bayesian network meta-analysis of randomized controlled trials.

Background: While total mesorectal excision is the gold standard for rectal cancer, the optimal surgical approach to achieve adequate oncological outcomes remains controversial. This network meta-analysis aims to compare the histopathological outcomes of robotic (R-RR), transanal (Ta-RR), laparoscopic (L-RR), and open (O-RR) resections for rectal cancer.

Materials And Methods: MEDLINE, Embase, and the Cochrane Library were screened from inception to June 2024.