Predictive Factors of the Degrees of Malnutrition According to GLIM Criteria in Head and Neck Cancer Patients: Valor Group.

Malnutrition is highly prevalent in patients with head and neck cancer, with relevant consequences in the treatment results. Multicenter observational study including 514 patients diagnosed with HNC. The morphofunctional assessment was carried out during the first 2 weeks of radiotherapy treatment.

Filamin A C-terminal fragment modulates Orai1 expression by inhibition of protein degradation.

Filamin A (FLNA) is an actin-binding protein that has been reported to interact with STIM1 modulating the activation of Orai1 channels. Cleaving of FLNA by calpain leads to a C-terminal fragment that is involved in a variety of functional and pathological events, including pro-oncogenic activity in different types of cancer. Here we show that full-length FLNA is downregulated in samples from colon cancer patients as well as in the adenocarcinoma cell line HT-29.

Use of the Hyperbaric Chamber Versus Conventional Treatment for the Prevention of Amputation in Chronic Diabetic Foot and the Influence on Fitting and Rehabilitation: A Systematic Review.

Diabetes mellitus (DM) is one of the most common chronic endocrine diseases, characterized by hyperglycemia, due to abnormal nitric oxide synthesis. The trend of an increase in the number of patients with DM continues. The medical and economic burden of DM is not only associated with hyperglycemia management but also with the management of DM-related complications.

Exploring Gender-Based Disparities in Finalist Technical-Tactical Actions: A Study of Amateur and Professional Padel Players.

Our aim in this study was to analyze gender differences across amateur and professional padel players related to the last shot of each rally. We analyzed a total of 180 games per category (professional and amateur), with 90 games for each gender. We performed descriptive and inferential analyses, including the Chi-square (χ2) statistical test, the Cramer's V coefficient (Vc), subsequent Z-tests and corrected standard residuals (CSR).

Age-related variations in physical activity, happiness, and psychological well-being: Evidence from Iran.

Background: Physical activity (PA) is associated with higher levels of PWB and happiness. The high prevalence of physical inactivity among the Iranian population is concerning. Moreover, according to the Happiness Report 2024, Iran is ranked 100th out of 143 countries.

Characterization of the External Load of Soccer Goalkeepers Depending on the Category and Sports Context.

Background/objectives: Studies focused on the soccer goalkeeper position in training and official matches are scarce. The present study aimed to analyze the external load during training sessions and official matches in semi-professional goalkeepers.

Methods: Data from goalkeepers (n = 6) from the youth ranks of a professional team belonging to the first Spanish soccer league have been used.

Exploring the druggability of the UEV domain of human TSG101 in search for broad-spectrum antivirals.

The ubiquitin E2 variant domain of TSG101 (TSG101-UEV) plays a pivotal role in protein sorting and virus budding by recognizing PTAP motifs within ubiquitinated proteins. Disruption of TSG101-UEV/PTAP interactions has emerged as a promising strategy for the development of host-oriented broad-spectrum antivirals with low susceptibility to resistance. TSG101 is a challenging target characterized by an extended and flat binding interface, low affinity for PTAP ligands, and complex binding energetics.

Prescription and Non-Prescription Anxiolytic Use is Linked to Personal Characteristics Among University Students.

Mental health promotion and substance use prevention are essential issues at universities worldwide. Although research has identified risk and protective factors for substance use generally among college students, there is a paucity of knowledge about anxiolytic use. Thus, the main objective of this study was to analyze if prescription and non-prescription anxiolytic use was related to self-control, self-esteem and self-efficacy.

Breeding species for resistance to disease in the Iberian Peninsula.

Alders are widely distributed riparian trees in Europe, North Africa and Western Asia. Recently, a strong reduction of alder stands has been detected in Europe due to infection by species (Stramenopila kingdom). This infection causes a disease known as alder dieback, characterized by leaf yellowing, dieback of branches, increased fruit production, and bark necrosis in the collar and basal part of the stem.

Synergic Integration of the miRNome, Machine Learning and Bioinformatics for the Identification of Potential Disease-Modifying Agents in Obstructive Sleep Apnea.

Introduction: Understanding the diverse pathogenetic pathways in obstructive sleep apnea (OSA) is crucial for improving outcomes. microRNA (miRNA) profiling is a promising strategy for elucidating these mechanisms.

Objective: To characterize the pathogenetic pathways linked to OSA through the integration of miRNA profiles, machine learning (ML) and bioinformatics.

Exercise-induced anxiety impairs local and systemic inflammatory response and glucose metabolism in C57BL/6J mice.

Introduction: The complex physiological and psychological responses to regular exercise are yet to be fully elucidated. Exercise strongly modulates the immune system, inducing a plethora of dynamic responses involving the innate immune cell function and inflammatory processes that contribute to both potential health benefits and harmful side effects. Indeed, the relationship between physical exercise, stress, immunity, and metabolism serves as a paramount model of neuroimmunoendocrine interaction.

Correlation Study and Predictive Modelling of Ergonomic Parameters in Robotic-Assisted Laparoscopic Surgery.

Background: This study aims to continue research on the objective analysis of ergonomic conditions in robotic-assisted surgery (RAS), seeking innovative solutions for the analysis and prevention of ergonomic problems in surgical practice.

Methods: Four different robotic-assisted tasks were performed by groups of surgeons with different surgical experiences. Different wearable technologies were used to record surgeons' posture and muscle activity during surgical practice, for which the correlation between them was analyzed.

Identification of Game Periods and Playing Position Activity Profiles in Elite-Level Beach Soccer Players Through Principal Component Analysis.

Beach soccer has gained increasing interest for study in the sports sciences. In this sense, the analysis of activity profiles is important for training design and load individualization. Therefore, the aims of this study were to identify the most important variables to assess the activity profile and to compare them according to the playing position and game periods in international beach soccer matches.

Precise Mechanical Oscillator Design and Calibration for Characterising Sub-Millimetre Movements in mmWave Radar Systems.

For many industrial and medical applications, measuring sub-millimetre movements has become crucial, for instance, for the precise guidance of surgical robots. The literature shows the feasibility of millimetre-wave (mmWave) radars to deal with such micro-vibrations. However, the availability of reference devices to configure and test these systems is very limited.

Analysis of Dry Needling Combined with an Exercise Program in the Treatment of Knee Osteoarthritis: A Randomized Clinical Trial.

Therapeutic exercise is recommended for people with knee osteoarthritis (OA), although it could be complemented with other treatments such as dry needling (DN). The purpose of this study was to evaluate and compare the resulting data on pain, functionality, strength and range of motion in subjects with knee osteoarthritis after being treated with a specific therapeutic physical exercise program alone or in combination with the DN technique in the popliteus muscle. : A total of 33 participants were randomly assigned to two groups: the dry needling plus therapeutic physical exercise group ( = 15) and the therapeutic physical exercise alone group ( = 18).

The Clinical Usefulness of Evaluating the Lens and Intraocular Lenses Using Optical Coherence Tomography: An Updated Literature Review.

The Lens Dysfunction Syndrome includes two widespread ocular disorders: presbyopia and cataract. Understanding its etiology, onset, progression, impact, prevention, and treatment remains a significant scientific challenge. The lens is a fundamental structure of the ocular dioptric system that allows for focus adjustment or accommodation to view objects at different distances.

Relationship Between Body Composition and Physical Literacy in Chilean Children (10 to 16 Years): An Assessment Using CAPL-2.

The aim of this study was to evaluate the levels of physical literacy (PL) in school children (10 to 16 years) in Santiago, Chile, and to explore the relationship between PL and body mass index (BMI). In addition, gender and age differences were analyzed in relation to PL levels in a context where childhood obesity remains a public health challenge. A total of 439 students in grades 5-8 were assessed using the Canadian Assessment of Physical Literacy-2 (CAPL-2) questionnaire.

Associations Among Reduced Income, Unhealthy Habits, the Prevalence of Non-Communicable Diseases, and Multimorbidity in Middle-Aged and Older US Adults: A Cross-Sectional Study.

Introduction: Evidence supports the relationships between socioeconomic status and access to health care, incidence of pathologies, and lifestyle.

Objective: The aim of this research was to investigate whether there are associations between having a household income below the poverty line, and participation in unhealthy lifestyle habits, the prevalence of non-communicable diseases, and the number of comorbidities in US middle-aged and older adults.

Methods: This cross-sectional study is based on the NHANES 2011-2020.

Diabetes Eye Disease Sufferers and Non-Sufferers Are Differentiated by Sleep Hours, Physical Activity, Diet, and Demographic Variables: A CRT Analysis.

Introduction: Diabetic eye disease is the most common microvascular complication of diabetes mellitus. This complication has some direct impact on an individual's well-being and health. Some lifestyle habits have been associated with the incidence of these co-morbidities.

Impacts of Square Stepping Exercise on Physical-Cognitive Function, Biomarkers, Body Composition and Mental Health in Healthy Senior Aged 60 and Above: A Systematic Review.

: The aim of this systematic review is to analyze the effects of Square Stepping Exercise (SSE) on physical and cognitive function in older people, including its effects on biomarkers, body composition and mental health, focusing only on research that assessed the efficacy of SSE-based interventions. : PubMed, Web of Science, Scopus and Cochrane databases were searched from June 2006 to June 2024 according to the PRISMA guidelines. The main search terms used were related to "older people" and "square-stepping exercise".

Comprehensive Analysis of Bioactive Compounds, Functional Properties, and Applications of Broccoli By-Products.

Broccoli by-products, traditionally considered inedible, possess a comprehensive nutritional and functional profile. These by-products are abundant in glucosinolates, particularly glucoraphanin, and sulforaphane, an isothiocyanate renowned for its potent antioxidant and anticarcinogenic properties. Broccoli leaves are a significant source of phenolic compounds, including kaempferol and quercetin, as well as pigments, vitamins, and essential minerals.

Assessment of Greenhouse Gas Emissions and Carbon Sequestration in Dairy Goat Farming Systems in Northern Extremadura, Spain.

Livestock farming is an activity closely linked to the environment, directly affecting its surrounding ecosystem while utilizing the natural resources it provides. Accordingly, it is essential to study these production systems in order to implement more sustainable models that allow for a balance between socioeconomic and environmental factors. The main objective of this study was to analyze the environmental impact of nine different dairy goat production systems located in northern Extremadura, Spain.